The Family Tree Guide to DNA Testing and Genetic Genealogy
The Family Tree Guide to DNA Testing and Genetic Genealogy

Author: Blaine T. Bettinger

Publisher: Penguin

Published: 2019-08-13

Total Pages: 274

ISBN-13: 1440300577

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Unlock the family secrets in your DNA! Discover the answers to your family history mysteries using the most cutting edge tool available. This plain-English guide (newly updated and expanded to include th latest DNA developments) will teach you what DNA tests are available; the pros and cons of the major testing companies; and how to choose the right test to answer your specific genealogy questions. And once you've taken a DNA test, this guide will help you use your often-overwhelming results, with tips for understanding ethnicity estimates, navigating suggested cousin matches, and using third-party tools like GEDmatch to further analyze your data. The book features: · Colorful diagrams and expert definitions that explain key DNA terms and concepts such as haplogroups and DNA inheritance patterns · Detailed guides to each of the major kinds of DNA tests and tips for selecting the DNA test that can best help you solve your family mysteries, with case studies showing how each can be useful · Information about third-party tools you can use to more thoroughly analyze your test results once you've received them · Test comparison guides and research forms to help you select the most appropriate DNA test and organize your results · Insights into how adoptees and others who know little about their ancestry can benefit from DNA testing Whether you've just heard of DNA testing or you've tested at all three major companies, this guide will give you the tools you need to unpuzzle your DNA and discover what it can tell you about your family tree.

The Family Gene
The Family Gene

Author: Joselin Linder

Publisher: HarperCollins

Published: 2017-03-14

Total Pages: 245

ISBN-13: 0062378929

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A riveting medical mystery about a young woman’s quest to uncover the truth about her likely fatal genetic disorder that opens a window onto the exploding field of genomic medicine When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. Delving further into the past, she discovered that her great-grandmother had displayed symptoms similar to hers before her death. Clearly, this was more than a fluke. Setting out to build a more complete picture of the illness that haunted her family, Joselin approached Dr. Christine Seidman, the head of a group of world-class genetic researchers at Harvard Medical School, for help. Dr. Seidman had been working on her family’s case for twenty years and had finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation. Here, Joselin tells the story of their gene: the lives it claimed and the future of genomic medicine with the potential to save those that remain. Digging into family records and medical history, conducting interviews with relatives and friends, and reflecting on her own experiences with the Harvard doctor, Joselin pieces together the lineage of this deadly gene to write a gripping and unforgettable exploration of family, history, and love. A compelling chronicle of survival and perseverance, The Family Gene is an important story of a young woman reckoning with her father’s death, her own mortality, and her ethical obligations to herself and those closest to her.

The Genealogy of a Gene
The Genealogy of a Gene

Author: Myles W. Jackson

Publisher: MIT Press

Published: 2015-03-06

Total Pages: 349

ISBN-13: 0262327201

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The history of the CCR5 gene as a lens through which to view such issues as intellectual property, Big Pharma, personalized medicine, and race and genomics. In The Genealogy of a Gene, Myles Jackson uses the story of the CCR5 gene to investigate the interrelationships among science, technology, and society. Mapping the varied “genealogy” of CCR5—intellectual property, natural selection, Big and Small Pharma, human diversity studies, personalized medicine, ancestry studies, and race and genomics—Jackson links a myriad of diverse topics. The history of CCR5 from the 1990s to the present offers a vivid illustration of how intellectual property law has changed the conduct and content of scientific knowledge, and the social, political, and ethical implications of such a transformation. The CCR5 gene began as a small sequence of DNA, became a patented product of a corporation, and then, when it was found to be an AIDS virus co-receptor with a key role in the immune system, it became part of the biomedical research world—and a potential moneymaker for the pharmaceutical industry. When it was further discovered that a mutation of the gene found in certain populations conferred near-immunity to the AIDS virus, questions about race and genetics arose. Jackson describes these developments in the context of larger issues, including the rise of “biocapitalism,” the patentability of products of nature, the difference between U.S. and European patenting approaches, and the relevance of race and ethnicity to medical research.

The Genealogical Science
The Genealogical Science

Author: Nadia Abu El-Haj

Publisher: University of Chicago Press

Published: 2012-04-26

Total Pages: 323

ISBN-13: 0226201406

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This volume analyses the scientific work and social implications of the flourishing field of genetic history. The author examines genetic history's working assumptions about culture and nature, identity and biology, and the individual and the collective.

Trace Your Roots with DNA
Trace Your Roots with DNA

Author: Megan Smolenyak Smolenyak

Publisher: Rodale Books

Published: 2004-10-07

Total Pages: 290

ISBN-13: 1609616162

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Written by two of the country's top genealogists, this is the first book to explain how new and groundbreaking genetic testing can help you research your ancestry According to American Demographics, 113 million Americans have begun to trace their roots, making genealogy the second most popular hobby in the country (after gardening). Enthusiasts clamor for new information from dozens of subscription-based websites, email newsletters, and magazines devoted to the subject. For these eager roots-seekers looking to take their searches to the next level, DNA testing is the answer. After a brief introduction to genealogy and genetics fundamentals, the authors explain the types of available testing, what kind of information the tests can provide, how to interpret the results, and how the tests work (it doesn't involve digging up your dead relatives). It's in expensive, easy to do, and the results are accurate: It's as simple as swabbing the inside of your cheek and popping a sample in the mail. Family lore has it that a branch of our family emigrated to Argentina and now I've found some people there with our name. Can testing tell us whether we're from the same family? My mother was adopted and doesn't know her ethnicity. Are there any tests available to help her learn about her heritage? I just discovered someone else with my highly unusual surname. How can we find out if we have a common ancestor? These are just a few of the types of genealogical scenarios readers can pursue. The authors reveal exactly what is possible-and what is not possible-with genetic testing. They include case studies of both famous historial mysteries and examples of ordinary folks whose exploration of genetic genealogy has enabled them to trace their roots.

NextGen Genealogy
NextGen Genealogy

Author: David R. Dowell Ph.D.

Publisher: Bloomsbury Publishing USA

Published: 2014-11-25

Total Pages: 276

ISBN-13:

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DNA testing can serve as a powerful tool that unlocks the hidden information within our bodies for family history research. This book explains how genetic genealogy works and answers the questions of genealogists and individuals seeking information on their family trees. Now that DNA testing for genealogical purposes has existed for nearly a decade and a half—and been refined and improved during that time—it has established its value among family history researchers. It is now becoming accepted as another tool in the kit of well-rounded genealogists. This book covers this fast-growing application of genetics, empowering genealogists to apply this information to further their research. It will also enable general readers to understand how genetic information can be applied to verify or refute documentary research—and to break down frustrating walls that block the discovery of ancestors. The book describes the three major categories of DNA testing for family history research: Y-chromosome tests for investigating paternal (surname) lines, mitochondrial tests for investigating maternal (umbilical) lines, and autosomal tests for exploring close relationships. Expert genealogist David Dowell provides guidance on deciding which test to take and identifying which members of your family should be tested to answer your most important genealogical questions. Readers will also learn how to interpret the results of tests and methods for further analysis to get additional value from them.

The Stranger in My Genes
The Stranger in My Genes

Author: Bill Griffeth

Publisher: New England Historic Genealogical Society

Published: 2016-09-06

Total Pages: 198

ISBN-13: 088082350X

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Bill Griffeth, longtime genealogy buff, takes a DNA test that has an unexpected outcome: "If the results were correct, it meant that the family tree I had spent years documenting was not my own." Bill undertakes a quest to solve the mystery of his origins, which shakes his sense of identity. As he takes us on his journey, we learn about choices made by his ancestors, parents, and others - and we see Bill measure and weigh his own difficult choices as he confronts the past.

The Practical Guide to the Genetic Family History
The Practical Guide to the Genetic Family History

Author: Robin L. Bennett

Publisher: John Wiley & Sons

Published: 2011-09-20

Total Pages: 389

ISBN-13: 1118209818

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HELPS YOU DEVELOP AND ASSESS PEDIGREES TO MAKE DIAGNOSES, EVALUATE RISK, AND COUNSEL PATIENTS The Second Edition of The Practical Guide to the Genetic Family History not only shows how to take a medical-family history and record a pedigree, but also explains why each bit of information gathered is important. It provides essential support in diagnosing conditions with a genetic component. Moreover, it aids in recommending genetic testing, referring patients for genetic counseling, determining patterns of inheritance, calculating risk of disease, making decisions for medical management and surveillance, and informing and educating patients. Based on the author's twenty-five years as a genetic counselor, the book also helps readers deal with the psychological, social, cultural, and ethical problems that arise in gathering a medical-family history and sharing findings with patients. Featuring a new Foreword by Arno Motulsky, widely recognized as the founder of medical genetics, and completely updated to reflect the most recent findings in genetic medicine, this Second Edition presents the latest information and methods for preparing and assessing a pedigree, including: Value and utility of a thorough medical-family history Directed questions to ask when developing a medical-family history for specific disease conditions Use of pedigrees to identify individuals with an increased susceptibility to cancer Verification of family medical information Special considerations when adoptions or gamete donors are involved Ethical issues that may arise in recording a pedigree Throughout the book, clinical examples based on hypothetical families illustrate key concepts, helping readers understand how real issues present themselves and how they can be resolved. This book will enable all healthcare providers, including physicians, nurses, medical social workers, and physician assistants, as well as genetic counselors, to take full advantage of the pedigree as a primary tool for making a genetic risk assessment and providing counseling for patients and their families.

DNA and Genealogy
DNA and Genealogy

Author: Colleen Fitzpatrick

Publisher: Mitchell Beazley

Published: 2005

Total Pages: 192

ISBN-13:

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"The genetic trail an ancestor leaves behind is every bit as important as his paper trail. Though Y-chromosome and mitochondrial DNA testing, the modern genealogist has a powerful new tool for researching his roots" -- back cover.

Ancestors in Our Genome
Ancestors in Our Genome

Author: Eugene E. Harris (Professor)

Publisher:

Published: 2015

Total Pages: 249

ISBN-13: 0199978034

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In 2001, scientists were finally able to determine the full human genome sequence, and with the discovery began a genomic voyage back in time. Since then, we have sequenced the full genomes of a number of mankind's primate relatives at a remarkable rate. The genomes of the common chimpanzee (2005) and bonobo (2012), orangutan (2011), gorilla (2012), and macaque monkey (2007) have already been identified, and the determination of other primate genomes is well underway. Researchers are beginning to unravel our full genomic history, comparing it with closely related species to answer age-old questions about how and when we evolved. For the first time, we are finding our own ancestors in our genome and are thereby gleaning new information about our evolutionary past. In Ancestors in Our Genome, molecular anthropologist Eugene E. Harris presents us with a complete and up-to-date account of the evolution of the human genome and our species. Written from the perspective of population genetics, and in simple terms, the book traces human origins back to their source among our earliest human ancestors, and explains many of the most intriguing questions that genome scientists are currently working to answer. For example, what does the high level of discordance among the gene trees of humans and the African great apes tell us about our respective separations from our common ancestor? Was our separation from the apes fast or slow, and when and why did it occur? Where, when, and how did our modern species evolve? How do we search across genomes to find the genomic underpinnings of our large and complex brains and language abilities? How can we find the genomic bases for life at high altitudes, for lactose tolerance, resistance to disease, and for our different skin pigmentations? How and when did we interbreed with Neandertals and the recently discovered ancient Denisovans of Asia? Harris draws upon extensive experience researching primate evolution in order to deliver a lively and thorough history of human evolution. Ancestors in Our Genome is the most complete discussion of our current understanding of the human genome available.