Asymmetric Phase Transfer Catalysis
Asymmetric Phase Transfer Catalysis

Author: Keiji Maruoka

Publisher: John Wiley & Sons

Published: 2008-09-08

Total Pages: 228

ISBN-13: 3527622632

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Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Catalytic Asymmetric Synthesis
Catalytic Asymmetric Synthesis

Author: Takahiko Akiyama

Publisher: John Wiley & Sons

Published: 2022-05-27

Total Pages: 798

ISBN-13: 1119736412

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Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.

Iodine Catalysis in Organic Synthesis
Iodine Catalysis in Organic Synthesis

Author: Kazuaki Ishihara

Publisher: John Wiley & Sons

Published: 2022-05-16

Total Pages: 452

ISBN-13: 3527348298

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Iodine Catalysis in Organic Synthesis The first book of its kind to highlight iodine as a sustainable alternative to conventional transition metal catalysis Iodine Catalysis in Organic Synthesis provides detailed coverage of recent advances in iodine chemistry and catalysis, focusing on the utilization of various iodine-containing compounds as oxidative catalysts. Featuring contributions by an international panel of leading research chemists, this authoritative volume explores the development of environmentally benign organic reactions and summarizes catalytic transformations of molecular iodine and iodine compounds such as hypervalent organoiodine and inorganic iodine salts. Readers are first introduced to the history of iodine chemistry, the conceptual background of homogeneous catalysis, and the benefits of iodine catalysis in comparison with transition metals. Next, chapters organized by reaction type examine enantioselective transformations, catalytic reactions involving iodine, catalyst states, oxidation in iodine and iodine catalyses, and catalytic reactions based on halogen bonding. Practical case studies and real-world examples of different applications in organic synthesis and industry are incorporated throughout the text. An invaluable guide for synthetic chemists in both academic and industrial laboratories, Iodine Catalysis in Organic Synthesis: Provides a thorough overview of typical iodine-catalyzed reactions, catalyst systems, structures, and reactivity Explores promising industrial applications of iodine-based reagents for organic synthesis Highlights the advantages iodine catalysis has over classical metal-catalyzed reactions Discusses sustainable and eco-friendly methods in hypervalent iodine chemistry Edited by two world authorities on the catalytic applications of organoiodine compounds, Iodine Catalysis in Organic Synthesis is required reading for catalytic, organic, and organometallic chemists, medicinal and pharmaceutical chemists, industrial chemists, and academic researchers and advanced students in relevant fields.

Enantioselective Synthesis of Beta-Amino Acids
Enantioselective Synthesis of Beta-Amino Acids

Author: Eusebio Juaristi

Publisher: John Wiley & Sons

Published: 2005-05-06

Total Pages: 658

ISBN-13: 0471698474

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Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase in the literature published on the subject, interest in ß-amino acids has grown over the past several years. With major pharmaceutical applications, these amino acids are now studied across multiple lines of research, including combinatorial chemistry, medicinal chemistry, molecular design, proteomics, and others. This Second Edition of Enantioselective Synthesis of ß-Amino Acids updates reviews included in the First Edition while also covering new developments since its publication. The book presents detailed discussions of the most important methods for the synthesis of ß-amino acids. In most cases, the lead chemist who originally developed a method provides an authoritative description of it. In addition, Enantioselective Synthesis of ß-Amino Acids, Second Edition: * Features introductory overviews on the structural types of relevant ß-amino acid targets and salient ß-amino acids present in natural products * Dedicates several chapters to advances in the synthesis of oligomers from ß-amino acids * Includes general and practical procedures for the preparation of ß-amino acids in each chapter * Discusses the most important methods that have been recently developed for the asymmetric synthesis of cyclic and open-chain ß-amino acids * Includes a report on the preparation of libraries of enantiopure ß-amino acids using combinatorial approaches The only book of its kind available today, Enantioselective Synthesis of ß-Amino Acids, Second Edition offers upper-level students and professionals an essential resource for pharmaceutical development, medicinal chemistry, and biochemistry.

Organo-catalytic Strategies Towards Alpha, Alpha - Disubstituted Amino Acid Derivatives
Organo-catalytic Strategies Towards Alpha, Alpha - Disubstituted Amino Acid Derivatives

Author: Henning Vogt

Publisher:

Published: 2006

Total Pages: 195

ISBN-13: 9783832513825

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The class of non-proteinogenic a,a u2011disubstituted amino acids and their derivatives is of high interest to biochemical and pharmacological research. This predicates on their ability to alter certain chemical and physicochemical properties of peptides and related structures. Moreover, the close structural relatedness to biologically relevant endogenous amino acid derivatives qualifies them in many cases to act as enzyme inhibitors or receptor antagonists.In the present study, the development of new strategies towards the synthesis of N u2011protected a,a u2011disubstituted amino aldehydes and their derivatives is demonstrated. Starting from ketones, a,a u2011disubstituted aldehydes were prepared in two or three steps. These aldehydes were subjected to stereoselective organo-catalysed a u2011amination reactions. The transfer of a procedure known for the a u2011amination of a u2011unbranched aldehydes with azodicarboxylates to racemic a u2011branched aldehydes delivered N u2011protected aminoaldehydes in up to 87 % yield and 86 % ee. The conversion of the amination products to the corresponding N u2011protected 4,4 u2011disubstituted oxazolidinones was accomplished, after in situ-reduction, in two additional steps.In addition to this method, a new strategy was devised using sulfonyl azides as aminating agent to deliver a u2011sulfamidated a,a u2011disubstituted aldehydes in up to 55 % yield and 86 % ee. A mechanism was proposed, which differs fundamentally from the mechanistic model usually ascribed to enamine catalysis. The transformation of the sulfamidation product into the free amino acid was accomplished in two steps.Since the two concepts follow different mechanistic routes, different enantiomers of N u2011protected, a,a u2011disubstituted aminoaldehydes are accessible by one catalyst. All reactions involved in the latter approach are free of transition metals. Therefore, the presented strategy could prove to be especially useful for medicinal chemistry.

Phase-transfer Catalysis
Phase-transfer Catalysis

Author: Marc Halpern

Publisher:

Published: 1997

Total Pages: 336

ISBN-13:

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The symposium was held in Honolulu in December 1995 as part of the International Chemical Congress of Pacific Basin Societies. The 22 papers document the research over the past decade that has allowed the exponential growth of phase-transfer catalysis in both laboratories and the commercial manufacture of organic chemicals and polymers. Among the topics are mechanisms and applications of solid-liquid phase-transfer catalysis, micellar catalysis in two-phase systems, the use of chiral quaternary salts in asymmetric synthesis, and the rate- limiting step in triphase catalysis for esterifying phenols. Annotation copyrighted by Book News, Inc., Portland, OR.

Handbook of Phase Transfer Catalysis
Handbook of Phase Transfer Catalysis

Author: Y. Sasson

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 579

ISBN-13: 9400900236

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Phase transfer catalysis is a sophisticated chemical technique which can be used to perform a variety of chemical reactions under mild conditions and with improved control. Since the concept was developed, both the theoretical and practical synthetic applications have seen considerable development, to the point where the technique can be applied to many areas of chemistry. Thus, phase transfer methods are now utilized in many applications, from research chemistry to full-scale production, where the benefits of faster, cleaner and more selective reactions are required. In this new book, the editors have brought together a range of contributors, each of whom is working at the forefront of the technology, to provide a clear, concise and ahtoritative review of this important area of chemistry. Industrial and academic chemists working on the synthesis, scale-up, production or analysis of a wide range of chemical products will find this book an essential reference on phase transfer technology.