The case of Paul Kammerer is a well researched and highly readable historical account of one of the biggest, till today unsolved scientific scandals. Paul Kammerer, 'the father of epigenetic, ' was a talented and idealistic biologist, whose ground-breaking research made headlines worldwide. Vienna at the turn of the 20th century, where Kammerer lived and worked, was at its creative peak yet already declining toward Nazism. The book that reads like a detective story, provides new evidence for the events that led to Kammerer's tragic end while exposing the implicit yet dangerous links between science and politics. AUTHOR BIOGRAPHY: With a background in the sociology of science, political science and philosophy, Klaus Taschwer lives in Vienna and is the science editor of the Austrian newspaper Der Standard. He is the founding editor of the science magazine heureka!, the co-author of Konrad Lorenz. A Biography and recipient of the 2016 Austrian State Award for Scientific Journalism. AUTHOR HOME: Vienna, Austri
On September 23, 1926, and Austrian experimental biologist named Dr. Paul Kammerer blew his brains out on a footpath in the Austrian mountains. His suicide was the climax of a great evolutionary controversy which his experiments had aroused. The battle was between the followers of Lamarck, who maintained that acquired characteristics could be inherited, and the neo-Darwinists, who upheld the theory of chance mutations preserved by natural selection. Dr. Kammerer's experiments with various amphibians, including salamanders and the midwife toad (Alytes obstetricans), lent much weight to the Lamarckian argument and drew upon him the full fury of the orthodox neo-Darwinists. Arthur Koestler had known about Dr. Kammerer's work when he himself was a student in Vienna, and he has always been interested in this tragic story. He gives a fascinating description of the venomous atmosphere in which the battle was fought and of the lengths to which apparently respectable scholars would go to discredit their opponents. Heading the attack on Kammerer was a British scientist, William Bateson, who hinted that the Viennese's experiments were fakes, but who failed to examine the evidence, including the so-called nuptial pads of Kammerer's last remaining specimen of the midwife toad. It was a young American scientist who delivered the coup de grace; on a visit to Vienna, he discovered that the discoloration of the nuptial pads was due not to natural causes but to the injection Indian ink. When his findings were published, Kammerer shot himself. Mr. Koestler, whose recent writings, in books such as The Act of Creation and The Ghost in the Machine, have been in part concerned with evolutionary theory, decided to investigate this old mystery. When he started on his researches, he expected to relate the tragedy of a man who had betrayed his calling, for Kammerer's suicide was accepted as a confession of guilt and his work was discredited from that day to this. Instead, as Mr. Koestler read the contemporary papers, corresponded with Kammerer's daughter, Bateson's son, and the surviving scientists who attended Kammerer's lecture in Cambridge, he found himself writing a vindication of a man who in all probability was himself betrayed. The story that emerges is, on one level, fascinating piece of scientific detection; on another, it is a moving and human narrative about a much abused, brilliant and lovable figure. Though no Lamarckian himself, Mr. Koestler ends the book with an appeal to biologists to repeat Kammerer's experiments with an open mind in order to verify or refute them. If Kammerer's claims were posthumously confirmed our outlook on evolution would be significantly changed. A superb intellectual thriller whose implications still reverberate today, The Case of the Midwife Toad is an entirely new kind of book for Mr. Koestler, and perhaps only he could have written it, for it required expert knowledge and familiarity with the academic world of science, combined with the creativity and imaginative insight of an outstanding novelist.
The Soviet agronomist Trofim Lysenko became one of the most notorious figures in twentieth-century science after his genetic theories were discredited decades ago. Yet some scientists, even in the West, now claim that discoveries in the field of epigenetics prove that he was right after all. Seeking to get to the bottom of Lysenko’s rehabilitation in certain Russian scientific circles, Loren Graham reopens the case, granting his theories an impartial hearing to determine whether new developments in molecular biology validate his claims. In the 1930s Lysenko advanced a “theory of nutrients” to explain plant development, basing his insights on experiments which, he claimed, showed one could manipulate environmental conditions such as temperature to convert a winter wheat variety into a spring variety. He considered the inheritance of acquired characteristics—which he called the “internalization of environmental conditions”—the primary mechanism of heredity. Although his methods were slipshod and his results were never duplicated, his ideas fell on fertile ground during a time of widespread famine in the Soviet Union. Recently, a hypothesis called epigenetic transgenerational inheritance has suggested that acquired characteristics may indeed occasionally be passed on to offspring. Some biologists dispute the evidence for this hypothesis. Loren Graham examines these arguments, both in Russia and the West, and shows how, in Russia, political currents are particularly significant in affecting the debates.
This book reviews the convoluted history of orthogenesis with an emphasis of non-English sources, untangles relationships between various concepts of directed evolution and argues whether orthogenesis has something to offer modern biology. Darwinism claims that evolution occurs by selection from an extensive random variability. An alternative viewpoint—that the material for variability is limited and organisms are predisposed to vary in certain directions—is the essence of evolutionary concepts that can be grouped together under the name of orthogenesis. Dating back to Lamarck, orthogenesis has existed in many guises. Branded as mystical and discarded as unscientific, it keeps re-emerging in evolutionary discussions.
This groundbreaking book represents the most systematic examination to date of the often-invoked but rarely examined declaration that "history matters." Most contemporary social scientists unconsciously take a "snapshot" view of the social world. Yet the meaning of social events or processes is frequently distorted when they are ripped from their temporal context. Paul Pierson argues that placing politics in time--constructing "moving pictures" rather than snapshots--can vastly enrich our understanding of complex social dynamics, and greatly improve the theories and methods that we use to explain them. Politics in Time opens a new window on the temporal aspects of the social world. It explores a range of important features and implications of evolving social processes: the variety of processes that unfold over significant periods of time, the circumstances under which such different processes are likely to occur, and above all, the significance of these temporal dimensions of social life for our understanding of important political and social outcomes. Ranging widely across the social sciences, Pierson's analysis reveals the high price social science pays when it becomes ahistorical. And it provides a wealth of ideas for restoring our sense of historical process. By placing politics back in time, Pierson's book is destined to have a resounding and enduring impact on the work of scholars and students in fields from political science, history, and sociology to economics and policy analysis.
The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support â€" or distort â€" practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices.
From New York Times bestselling author Sam Kean comes incredible stories of science, history, language, and music, as told by our own DNA. In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In THE VIOLINIST'S THUMB, he explores the wonders of the magical building block of life: DNA. There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists. Kean's vibrant storytelling once again makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.
In the summer of 1944, a shocking murder rocked the fledgling Beats. William S. Burroughs and Jack Kerouac, both still unknown, we inspired by the crime to collaborate on a novel, a hard-boiled tale of bohemian New York during World War II, full of drugs and art, obsession and brutality, with scenes and characters drawn from their own lives. Finally published after more than sixty years, this is a captivating read, and incomparable literary artifact, and a window into the lives and art of two of the twentieth century’s most influential writers.
