The Biophysical Characterisation of the Cell Surface
Author: Gajanan V. Sherbet
Publisher:
Published: 1978
Total Pages: 328
ISBN-13:
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Biochemical and Biophysical Roles of Cell Surface Molecules
Author: Kausik Chattopadhyay
Publisher: Springer
Published: 2019-01-12
Total Pages: 359
ISBN-13: 9811330654
DOWNLOAD EBOOKCell surface small molecules and macromolecules, such as members of cholesterol family (including steroid hormones), the glycolipid family (sphingolipids), the glycoprotein family (both N-linked and O-linked), and a vast array of other receptors have been shown to be involved in normal and abnormal cellular processes. The 11th International Symposium on Cell Surface Macromolecules, held in Mohali, India, in February 2017 provided a comprehensive update on the major advances in this area. Presenting selected contributions from this meeting, this book comprises 24 chapters, which provide in-depth analyses of data on the role of cell surface macromolecules in cellular function and their alterations associated with pathological conditions. It includes comprehensive research papers and critical overviews of the functional role of cell surface molecules, discussing topics such as biochemical, biophysical, and cell biological approaches to study cell membrane molecules, and metabolism of glycoconjugates.
Biophysics of the Cell Surface
Author: Roland Glaser
Publisher: Springer Science & Business Media
Published: 2013-03-07
Total Pages: 366
ISBN-13: 3642744710
DOWNLOAD EBOOKIt is common practice to publish conference papers in books or monograph series. This gives some advantage to those who did not have the opportunity to attend the meetings, but it irritates and disappoints others who may have hoped for a set of closely related reviews. With this book we have tried to find a compromise. It presents a selection from the topics which have been discussed in a series of inter national symposia entitled "Biophysics of Cell Surface", held in 1976, 1978, 1981, 1985 and 1988 in the GDR, and subsequently published in the journal STUDIA BIOPHYSICA (volumes 56, 74, 90, 110, 1271. Nearly all the contributors to this book participated in one or more of the meetings. We hope that our choice of topics selected for this book manages to reflect the variety and interest of the broad range of subjects which fall within the scope of membrane biophysics, without taking on the randomness of a scientific car-boot sale. We would like to express our thanks to all colleagues and organ~ isations who helped to realize the conferences and particularly this book. financial support for the symposia of 1985 and 1988 was provided by the IUPAB. A number of topics, reflected in this book, resulted in internat ional cooperations, supported by various organisations. We are especially grateful for the support of UNESCO research project on biophysicS in this respect. The European Bureau (ROSTE) of UNESCO supported the editorial work of this book.
Biochemical Roles of Eukaryotic Cell Surface Macromolecules
Author: Abhijit Chakrabarti
Publisher: Springer
Published: 2014-11-18
Total Pages: 411
ISBN-13: 3319112805
DOWNLOAD EBOOKConsists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.
Biochemical Roles of Eukaryotic Cell Surface Macromolecules
Author: Perumana R. Sudhakaran
Publisher: Springer Science & Business Media
Published: 2012-06-14
Total Pages: 343
ISBN-13: 1461433819
DOWNLOAD EBOOKCell surface molecules are critically important in regulating cell structure and function. Recent advances on the functional role of cell surface molecules, particularly glycoconjugates are presented in this book. Comprising of 22 chapters from the 2011 International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules, it covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell–matrix interaction.
Biophysical Characterization of Functional Peptides
Author: Vibin Ramakrishnan
Publisher: Springer Nature
Published: 2023-08-02
Total Pages: 142
ISBN-13: 1071634054
DOWNLOAD EBOOKThis protocol book presents reproducible and step-by-step procedures for the peptide synthesis, their characterization and applications. The volume includes an introductory section on in silico modelling of new peptide molecules, Molecular Dynamics Simulations, Docking, Electrostatic fingerprinting of peptides, and other modelling tools for peptide designing and optimization. Further, it covers protocols for the solid phase peptide synthesis, chromatographic and mass spectrometric characterization of peptides. Importantly, it covers methods for biophysical characterizations of peptides for their potential applications as drug delivery vehicles, peptide nano-assembly, bionanocatalysis, protein aggregation diseases, and peptide-based anti-bacterial.
Characterization of Biological Membranes
Author: Mu-Ping Nieh
Publisher: Walter de Gruyter GmbH & Co KG
Published: 2019-07-22
Total Pages: 716
ISBN-13: 3110544687
DOWNLOAD EBOOKThe study of membranes has become of high importance in the fields of biology, pharmaceutical chemistry and medicine, since much of what happens in a cell or in a virus involves biological membranes. The current book is an excellent introduction to the area, which explains how modern analytical methods can be applied to study biological membranes and membrane proteins and the bioprocesses they are involved to.
Deconstructing Complexity: Biophysical Characterization of Protein-Lipid Membranes
Author: Parkar
Publisher:
Published: 2024-06-15
Total Pages: 0
ISBN-13: 9783384262233
DOWNLOAD EBOOKBiochemical Roles of Eukaryotic Cell Surface Macromolecules
Author: Perumana R. Sudhakaran
Publisher: Springer
Published: 2014-06-11
Total Pages: 340
ISBN-13: 9781493901609
DOWNLOAD EBOOKCell surface molecules are critically important in regulating cell structure and function. Recent advances on the functional role of cell surface molecules, particularly glycoconjugates are presented in this book. Comprising of 22 chapters from the 2011 International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules, it covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell–matrix interaction.
Structural and Biophysical Characterization of Membrane-coating Proteins from the Nuclear Pore and the Primary Cilium
Author: Kevin Edward Knockenhauer
Publisher:
Published: 2016
Total Pages: 166
ISBN-13:
DOWNLOAD EBOOKA hallmark of eukaryotes is an endomembrane system that spatially separates cellular processes into discrete compartments. Macromolecular transport between these compartments canonically involves the fission and fusion of membrane-bound vesicles. Transport to and from the nucleus is a notable exception to this vesicular pathway. Additionally, transport to the primary cilium is not well characterized and is therefore of interest. The nuclear envelope comprises a double membrane that fuses at points to produce pores, which link the nucleoplasm with the cytoplasm. Coating these openings are nuclear pore complexes (NPCs), which regulate all nucleocytoplasmic trafficking by anchoring barrier forming FG-repeat proteins. At 60-120 MDa, the NPC is the largest macromolecular complex in the cell. However, it is a modular assembly formed by -30 different nucleoporins (Nups) arranged into stable subassemblies. One such module is the -600 kDa Y complex, which forms a Y shape and is the best characterized NPC subcomplex with crystal structures accounting for -90% of its total mass. The molecular details of how the short arms of the Y contact the long stem, in a region called the 'hub', were not known. We solved the structure of this last major missing piece of the Y complex to 4.1 A. This hub structure revealed unexpected curvature, allowed us to build the first atomic resolution composite of the mostly complete Y, and led to a novel higher order assembly model of the Y complex in the intact NPC. The ciliary membrane is topologically contiguous with the plasma membrane yet functionally distinct, due to a unique complement of integral membrane proteins. The Bardet- Biedl syndrome protein complex (BBSome) functions in the establishment or maintenance of this unique composition. The BBSome is -500 kDa octamer comprising BBS1, 2, 4, 5, 7, 8, 9, and BBIP10. To date, only the N-terminal domain of BBS1 had been structurally determined. In order to more completely characterize this complex, we have solved the structure of the BBS9 N-terminal [beta]-propeller to 1.8 A and determined its oligomeric state in solution. This structure has allowed us to identify a putative interaction site and characterized a disease relevant mutation on BBS9.
