The Neurobiology of Aging and Alzheimer Disease in Down Syndrome
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

Author: Elizabeth Head

Publisher: Academic Press

Published: 2021-08-31

Total Pages: 354

ISBN-13: 0128188464

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The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Cognitive Neuroscience of Aging
Cognitive Neuroscience of Aging

Author: Roberto Cabeza

Publisher: Oxford University Press

Published: 2016-10-31

Total Pages: 633

ISBN-13: 0190660236

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This second edition of the popular Cognitive Neuroscience of Aging provides up-to-date coverage of the most fundamental topics in this discipline. Like the first edition, this volume accessibly and comprehensively reviews the neural mechanisms of cognitive aging appropriate to both professionals and students in a variety of domains, including psychology, neuroscience, neuropsychology, neurology, and psychiatry. The chapters are organized into three sections. The first section focuses on major questions regarding methodological approaches and experimental design. It includes chapters on structural imaging (MRI, DTI), functional imaging (fMRI), and molecular imaging (dopamine PET, etc), and covers multimodal imaging, longitudinal studies, and the interpretation of imaging findings. The second section concentrates on specific cognitive abilities, including attention and inhibitory control, executive functions, memory, and emotion. The third section turns to domains with health and clinical implications, such as the emergence of cognitive deficits in middle age, the role of genetics, the effects of modulatory variables (hypertension, exercise, cognitive engagement), and the distinction between healthy aging and the effects of dementia and depression. Taken together, the chapters in this volume, written by many of the most eminent scientists as well as young stars in this discipline, provide a unified and comprehensive overview of cognitive neuroscience of aging.

Behavioral Neurobiology of Aging
Behavioral Neurobiology of Aging

Author: Marie-Christine Pardon

Publisher: Springer Science & Business Media

Published: 2012-04-15

Total Pages: 361

ISBN-13: 3642238750

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This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.

The Neuroscience of Aging
The Neuroscience of Aging

Author: Colin R. Martin

Publisher: Academic Press

Published: 2021-07-02

Total Pages: 1500

ISBN-13: 9780128183694

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Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain including Alzheimer's, stroke, and multiple sclerosis. Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. It also examines the use of animal modelling of aging and neurological disease. Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging: Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging Features sections on diagnosis and biomarkers of neurological aging, Alzheimer's, and stroke Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations Includes more than 500 illustrations and tables Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet: Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging Features sections on the genetics influencing aging and diseases of aging Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations Includes more than 500 illustrations and tables

The Aging Mind
The Aging Mind

Author: National Research Council

Publisher: National Academies Press

Published: 2000-04-18

Total Pages: 285

ISBN-13: 0309172195

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Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer's disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.

Behavioral Neuroscience
Behavioral Neuroscience

Author: Carl W. Cotman

Publisher: Academic Press

Published: 2014-04-24

Total Pages: 857

ISBN-13: 1483217566

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Behavioral Neuroscience: An Introduction provides a basic understanding of what is known about the means by which neurons communicate and about the nervous system which interprets, integrates, and transmits signals into meaningful and appropriate behaviors. The book starts with an overview of the nervous system. The text then describes the general operation and organization of the nervous system; and some of the major types of neurons in the context of their systems. The basic characteristics of neurons and how they communicate; the processes and the basic integrative properties of defined groups of neurons; and complex learning and memory are also considered. The book further tackles the auditory, somesthetic, olfactory, gustatory, visual, and motor systems; the functions of the autonomic nervous system and the neuroendocrine system; and the neural basis of two types of motivated behavior, drinking and feeding. The text also encompasses sleep and activity rhythms; the development of the neural circuitry and its plasticity throughout life; and the development of behavior. Behavioral disorders and the aspects of the human nervous system which make man unique among all living creatures are also looked into. Behavioral psychologists, behavioral neuroscientists, and psychobiologists will find the book invaluable.

Cognitive Aging
Cognitive Aging

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2015-07-21

Total Pages: 300

ISBN-13: 0309368650

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For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.

Factors Affecting Neurological Aging
Factors Affecting Neurological Aging

Author: Colin R Martin

Publisher: Academic Press

Published: 2021-06-01

Total Pages: 688

ISBN-13: 0128179910

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Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. - Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging - Features sections on the genetic components that influence aging and diseases of aging - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables

Nolte's Essentials of the Human Brain E-Book
Nolte's Essentials of the Human Brain E-Book

Author: Todd W. Vanderah

Publisher: Elsevier Health Sciences

Published: 2017-12-16

Total Pages: 242

ISBN-13: 0323568408

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Extensively revised throughout, Nolte's Essentials of the Human Brain, 2nd Edition, offers a reader-friendly overview of neuroscience and neuroanatomy ideal for studying and reviewing for exams. Updated content, integrated pathology and pharmacology for a more clinical focus, and full-color illustrations make a complex subject easier to understand. Test and verify your knowledge with review questions, unlabelled drawings, and more. - Includes explanatory color illustrations and brain images that visually depict structure-function relationships and key neuroscience concepts. - Provides multiple-choice and comprehensive review questions with explanations that cover core topics, so you can test and develop your knowledge. - Includes student-friendly features, such as chapter outlines, key concept boxes, high-yield headings, study questions at the end of each chapter, a comprehensive quiz with clinical vignettes, and blank diagrams that can be used for labelling practice. - Focuses on the clinical aspects of the nervous system with updated neuroscience content, integrated pathology and pharmacology content, and more clinically relevant questions. - Student ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and animations, designed to produce a more rounded learning experience.

The Cognitive Neuroscience of Working Memory
The Cognitive Neuroscience of Working Memory

Author: Naoyuki Osaka

Publisher:

Published: 2007

Total Pages: 418

ISBN-13: 0198570392

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It is only relatively recently that it has been possible to study the neural processes that might underlie working memory, leading to a proliferation of research in this domain. This volume brings together leading researchers from around the world to summarise current knowledge of this field.