The Adenosinergic System
The Adenosinergic System

Author: Micaela Morelli

Publisher:

Published: 2015

Total Pages:

ISBN-13: 9783319202747

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Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson's Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson's Disease, (2) an overview of neuroimaging studies in human health and disease, and (3) a study of urate as a possible biomarker and neuroprotectant.

The Adenosinergic System
The Adenosinergic System

Author: Micaela Morelli

Publisher: Springer

Published: 2015-10-01

Total Pages: 344

ISBN-13: 3319202731

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Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson's Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson's Disease, (2) an overview of neuroimaging studies in human death and disease and (3) a study of urate as a possible biomarker and neuroprotectant.

Caffeine for the Sustainment of Mental Task Performance
Caffeine for the Sustainment of Mental Task Performance

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2002-01-07

Total Pages: 172

ISBN-13: 0309082587

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This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

Adenosine in the Nervous System
Adenosine in the Nervous System

Author: Richard E. Stone

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 297

ISBN-13: 0080984193

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This volume in a series on neuroscience provides an overview of the last 20 years of research into the biochemistry, physiology,pharmacology and clinical therapeutic potential of adenosine and its analogues in the nervous system. Among the topics covered are adenosine transport in nervous systemtissues, adenosine production and metabolism and the electropharmacology of adenosine.

Adenosine Receptors in the Nervous System
Adenosine Receptors in the Nervous System

Author: J. A. Ribeiro

Publisher: Taylor & Francis Group

Published: 1989

Total Pages: 252

ISBN-13:

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A satellite Symposium on Adenosine Receptors in the Nervous System was held in April 1989 in Portugal. This book contains the manuscripts of the papers presented by the participants, who were from Europe, America and Asia.

Adenosine Receptors in Health and Disease
Adenosine Receptors in Health and Disease

Author: Constance N. Wilson

Publisher: Springer Science & Business Media

Published: 2009-07-28

Total Pages: 656

ISBN-13: 3540896155

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Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

The Adenosine Receptors
The Adenosine Receptors

Author: Pier Andrea Borea

Publisher: Humana Press

Published: 2018-07-28

Total Pages: 603

ISBN-13: 3319908081

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This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.

Adenosine Receptors
Adenosine Receptors

Author: Gyorgy Hasko

Publisher: CRC Press

Published: 2006-07-20

Total Pages: 377

ISBN-13: 1420005774

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After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the deve

Adenosine Receptors in Neurodegenerative Diseases
Adenosine Receptors in Neurodegenerative Diseases

Author: David Blum

Publisher: Academic Press

Published: 2017-03-10

Total Pages: 281

ISBN-13: 0128037458

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Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience. Comprehensive reference that details adenosine receptors in neurodegenerative disorders, with details on brain function and possible therapeutics Gives insights on how these receptors modulate the neurodegenerative outcomes in different disorders Edited by two of the leading researchers in the field regarding adenosine role in the brain in aging and neurodegenerative conditions