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Author: OECD
Publisher: OECD Publishing
Published: 2013-07-26
Total Pages: 20
ISBN-13: 926420380X
DOWNLOAD EBOOKThe present Test Guideline addresses the human health hazard endpoint skin corrosion, following exposure to a test chemical. Skin corrosion is defined as the production of irreversible tissue damage, manifested as visible necrosis of the skin ...
Author: OECD
Publisher: OECD Publishing
Published: 2004-11-23
Total Pages: 12
ISBN-13: 9264071121
DOWNLOAD EBOOKThe Globally Harmonised System for the Classification and Labelling of Chemicals defines skin corrosion as the production of irreversible tissue damage in the skin following the application of a test material. The test material (150 μL for liquids ...
Author:
Publisher:
Published: 2015
Total Pages: 15
ISBN-13:
DOWNLOAD EBOOKThis Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function. This Test Guideline was originally adopted in 2004 and updated in 2015 to refer to the IATA guidance document.
Author: OECD
Publisher: OECD Publishing
Published: 2015-07-28
Total Pages: 15
ISBN-13: 9264242732
DOWNLOAD EBOOKThis Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function.
Author: OECD
Publisher: OECD Publishing
Published: 2009-09-08
Total Pages: 20
ISBN-13: 9264070605
DOWNLOAD EBOOKThis method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author: Tim Marrs
Publisher: Royal Society of Chemistry
Published: 2018-02-26
Total Pages: 638
ISBN-13: 1782620664
DOWNLOAD EBOOKConsumer and environmental protection depend on the careful regulation of all classes of chemicals. Toxicology is the key science used to evaluate safety and so underpins regulatory decisions on chemicals. With the growing body of EU legislation involved in chemical regulation, there is a concomitant need to understand the toxicological principles underlying safety assessments. Regulatory Toxicology in the European Union is the first book to cover regulatory toxicology specifically in Europe. It addresses the need for a wider understanding of the principles of regulatory toxicology and their application and presents the relationship between toxicology and legislative processes in regulating chemical commodities across Europe. This title has a broad scope, covering historical and current chemical regulation in Europe, the role of European agencies and institutions, and also the use of toxicology data for important classes of chemicals, including human and veterinary medicines, animal feed and food additives, biocides, pesticides and nanomaterials. This book is therefore extremely pertinent and timely in the toxicology field at present. This book is an essential reference for regulatory authorities, industrialists, academics, undergraduates and postgraduates working within safety and hazards, toxicology, the biological sciences, and the medicinal and pharmaceutical sciences across the European Union.
Author: Natàlia Garcia-Reyero
Publisher: Springer
Published: 2018-02-24
Total Pages: 429
ISBN-13: 3319660845
DOWNLOAD EBOOKSocial pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.
Author:
Publisher:
Published: 2011
Total Pages: 932
ISBN-13:
DOWNLOAD EBOOKAuthor: U S Office of the Federal Register
Publisher: Government Printing Office
Published: 2013-01-08
Total Pages: 924
ISBN-13: 9780160914850
DOWNLOAD EBOOKThe Code of Federal Regulations is a codification of the general and permanent rules published in the Federal Register by the Executive departments and agencies of the United States Federal Government.
Author: OECD
Publisher: OECD Publishing
Published: 2015-07-28
Total Pages: 26
ISBN-13: 9264242759
DOWNLOAD EBOOKThe test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.
