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Author: OECD
Publisher: OECD Publishing
Published: 1995-07-27
Total Pages: 10
ISBN-13: 9264070966
DOWNLOAD EBOOKThe test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...
Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
Published: 1981
Total Pages:
ISBN-13: 9789264122215
DOWNLOAD EBOOKAuthor: National Research Council
Publisher: National Academies Press
Published: 2006-04-07
Total Pages: 270
ISBN-13: 0309164869
DOWNLOAD EBOOKToxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.
Author:
Publisher: DIANE Publishing
Published: 2002
Total Pages: 275
ISBN-13: 1428905375
DOWNLOAD EBOOKAuthor: OECD
Publisher: OECD Publishing
Published: 2018-06-27
Total Pages: 14
ISBN-13: 9264070826
DOWNLOAD EBOOKThis Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Published: 2010
Total Pages: 728
ISBN-13:
DOWNLOAD EBOOKThis report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Ronald D. Hood
Publisher: CRC Press
Published: 2005-08-30
Total Pages: 1164
ISBN-13: 1420040545
DOWNLOAD EBOOKCompletely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e
Author: OECD
Publisher: OECD Publishing
Published: 1996-03-22
Total Pages: 14
ISBN-13: 9264070982
DOWNLOAD EBOOKThe test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...
Author:
Publisher:
Published: 1992
Total Pages: 136
ISBN-13:
DOWNLOAD EBOOKAuthor: Saravana Babu Chidambaram
Publisher: Springer Nature
Published: 2022-02-11
Total Pages: 205
ISBN-13: 9811660921
DOWNLOAD EBOOKThis book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
