Teratological Testing
Teratological Testing

Author: T.V.N. Persaud

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 357

ISBN-13: 940116651X

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The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mec.;hanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The· contributions in this volume deal primarily with the areas of terato logical evaluation and the use of selected animal models for the study of con genital anomalies. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Teratogenicity Testing
Teratogenicity Testing

Author: Paul C. Barrow

Publisher: Humana Press

Published: 2012-11-09

Total Pages: 0

ISBN-13: 9781627031301

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Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.

Teratogenicity Testing
Teratogenicity Testing

Author: Luís Félix

Publisher: Humana

Published: 2019-06-27

Total Pages: 614

ISBN-13: 9781493993147

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This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs.

Teratology
Teratology

Author: C.L. Berry

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 246

ISBN-13: 3642661726

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In the fifteen years since the thalidomide disaster teratology has become a science in its own right, distinct from its progenitors, experimental embryology and develop mental biology, but bearing many of the familiar features of both parents. In this growth period there have been contributions from many different scientific disciplines as diverse as molecular biology and obstetrics, which have united in the field of study of congenital malformations. Scientists in academic departments, government research institutes and industrial pharmacology have all explored ways of evaluating the potential of drugs and chem icals to damage the embryo; strict methods of screening for teratogenicity have be come mandatory in most parts of the world. Despite a wealth of basic information in the fields of genetics and embryology, there is little concrete knowledge of the causal mechanisms of malformation in Man, and even less concerning the relevance to Man of those laboratory and animal tests which decide the fate of potentially useful drugs. It is timely, therefore, that in 1975 a group of young and active sci entists and clinicians concerned with the broader implications of teratology should review the past and look to the future of this emerging speciality. In this volume the editors have blended the opinions of teratologists; their message presages change in many of the old and accepted areas of investigative teratology.

In Vitro Toxicity Testing of Environmental Agents
In Vitro Toxicity Testing of Environmental Agents

Author: Alan R. Kolber

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 555

ISBN-13: 1461335663

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These two volumes contain the papers presented at a North Atlantic Treaty Organization (NATO) Advanced Study Institute held on September 22-28, 1979 in Monte Carlo, Monaco. The conference was entitled "In Vitro Toxicity Testing of Environmental Agents: Current and Future Possibilities." This international conference presented an opportunity for the participants to exchange informa tion and ideas on the current approaches (both scientific and po litical) for toxic assessment of environmental agents. The poten tial health effects of these compounds as well as future needs in the environmental research field were discussed. The scientific content of the conference seminars included an overview of the various cellular, subcellular, organ, animal, and genetic systems which have been used to assess the health effects of environmental agents. The scientific principles behind short term assays and an evaluation of their applicability to health effects monitoring and analysis were investigated. Included among major topics were: (1) the biochemistry and pharmacology of selected environmental agents; (2) molecular mechanisms of car cinogenesis, mutagenesis, and transformation; (3) bacterial muta genesis and toxicity; (4) mammalian cell mutagenesis, toxicity, and transformation; (5) in vitro carcinogens and mutagens; (6) teratogenic and other developmental toxic effects; and (7) the development of short-term neuro-behavioral toxicity assays.

Male Fertility and Its Regulation
Male Fertility and Its Regulation

Author: E.S. Hafez

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 474

ISBN-13: 9400948948

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Uncontrolled population growth, a significant problem for many countries, depresses real living standards in all developing areas. As a corollary, un controlled population growth also stresses the ability to deliver adequate reproductive health care on both national and individual levels. To focus on this and related problems an International Congress to examine many aspects of male and female Reproductive Health Center Care was held on 10-15 October 1982 in Maui, Hawaii, USA. This volume is a result of the proceedings from the 'Symposium on Male Fertility and its Regulation' which was a part of the Reproductive Health Care Congress. The organizers of this symposium recognized the need to focus male reproductive understanding on contraceptive development. The ultimate objective was and still is to produce a variety of safe and effective male contraceptives similar to that accomplished in the female. Speakers were invited to review the state of the art in several areas related to male contra ception, reproductive toxicity and reproductive biology. The abstracts of these sessions were published as a special issue of Archives of Andrology (Vol. 9, No.1, August, 1982). Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man uscripts from leaders in specific areas were solicited to provide additional range to the topics covered.

Teratology in the Twentieth Century
Teratology in the Twentieth Century

Author: H. Kalter

Publisher: Elsevier

Published: 2003-06-06

Total Pages: 167

ISBN-13: 0080542352

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This book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment.

Teratology
Teratology

Author:

Publisher:

Published: 1989

Total Pages: 672

ISBN-13:

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Publishes original reports of studies in all areas of abnormal development and related fields. It also welcomes reviews of topics of current significance and letters discussing papers that have appeard in Teratology or that deal with controversial scientific matters of interest to its readers.