Synapse Nine
Synapse Nine

Author: Eilis Muir

Publisher: Totally Entwined Group (USA+CAD)

Published: 2021-04-13

Total Pages: 224

ISBN-13: 1839434961

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FROM EXCITING SCI-FI ROMANCE AUTHOR EILIS MUIR Book one in the Deep Mesa series Elana denied her special abilities so she could live an ordinary life—until she's recruited into a top-secret project involving something otherworldly. The demands of followers seeking answers from Elana Ryan's special abilities had taken a toll. To feel normal again, she got a job working at Los Alamos National Lab. It worked—until she was recruited into a top-secret project to use the very gifts she'd left behind. The project's head scientist, Dr. Cameron Graeme, is pushy and arrogant, but Elana is also inexplicably drawn to him. As her abilities grow, she finds that his presence amplifies her powers. Now she fears her feelings for him and the intentions of the government. Dr. Graeme finds Elana irresistibly alluring, which conflicts with his responsibilities for her as an asset. They resist their mounting mutual desires, but something more powerful than either of them has a different plan in mind.

The Synapse
The Synapse

Author: Virginia M. Pickel

Publisher: Elsevier

Published: 2013-11-16

Total Pages: 529

ISBN-13: 0124186823

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The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. - Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. - Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. - Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. - Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings. - A comprehensive reference focused on the structure and function of the synapse - Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease - Detailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse - Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment

The Sticky Synapse
The Sticky Synapse

Author: Michael Hortsch

Publisher: Springer Science & Business Media

Published: 2009-06-07

Total Pages: 451

ISBN-13: 0387927085

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The molecular mechanisms, which are responsible for the functional differences between the various types of neuronal synapses, have become one of the central themes of modern neurobiology. It is becoming increasingly clear that a misregulation of synaptogenesis and synaptic remodeling and dysfunctional neuronal synapses are at the heart of several human diseases, both neurological disorders and psychiatric conditions. As synapses present specialized cellular junctions between neurons and their target cells, it may not come as a surprise that neural cell adhesion molecules (CAMs) are of special importance for the genesis and the maintenance of synaptic connections. Genes encoding adhesive molecules make up a significant portion of the human genome, and neural CAMs even have been postulated to be a major factor in the evolution of the human brain. These are just some of the many reasons why we thought a book on neural CAMs and their role in establishing and maintaining neuronal synapses would be highly appropriate for summarizing our current state of knowledge. Without question, over the near future, additional adhesive proteins will join the ranks of synaptic CAMs and our knowledge, and how these molecules enable neurons and their targets to communicate effectively will grow.

An Introduction to Neural Networks
An Introduction to Neural Networks

Author: James A. Anderson

Publisher: MIT Press

Published: 1995

Total Pages: 680

ISBN-13: 9780262510813

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An Introduction to Neural Networks falls into a new ecological niche for texts. Based on notes that have been class-tested for more than a decade, it is aimed at cognitive science and neuroscience students who need to understand brain function in terms of computational modeling, and at engineers who want to go beyond formal algorithms to applications and computing strategies. It is the only current text to approach networks from a broad neuroscience and cognitive science perspective, with an emphasis on the biology and psychology behind the assumptions of the models, as well as on what the models might be used for. It describes the mathematical and computational tools needed and provides an account of the author's own ideas. Students learn how to teach arithmetic to a neural network and get a short course on linear associative memory and adaptive maps. They are introduced to the author's brain-state-in-a-box (BSB) model and are provided with some of the neurobiological background necessary for a firm grasp of the general subject. The field now known as neural networks has split in recent years into two major groups, mirrored in the texts that are currently available: the engineers who are primarily interested in practical applications of the new adaptive, parallel computing technology, and the cognitive scientists and neuroscientists who are interested in scientific applications. As the gap between these two groups widens, Anderson notes that the academics have tended to drift off into irrelevant, often excessively abstract research while the engineers have lost contact with the source of ideas in the field. Neuroscience, he points out, provides a rich and valuable source of ideas about data representation and setting up the data representation is the major part of neural network programming. Both cognitive science and neuroscience give insights into how this can be done effectively: cognitive science suggests what to compute and neuroscience suggests how to compute it.

Building up the inhibitory synapse
Building up the inhibitory synapse

Author: Enrico Cherubini

Publisher: Frontiers E-books

Published:

Total Pages: 159

ISBN-13: 2889190978

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Fast inhibitory transmission exerts a powerful control on neuronal excitability and network oscillations thought to be associated with high cognitive functions. An alteration of inhibitory signaling is associated with major neurological and psychiatric disorders including epilepsy. Once released from presynaptic nerve terminals, GABA and glycine cross the synaptic cleft and bind to postsynaptic receptors localized in precise apposition to presynaptic release sites. The functional organization of inhibitory synapses consists in a dynamic process which relies on a number of highly specialized proteins that ensure the correct targeting, clustering, stabilization and subsequent fate of synaptic receptors. Among the proteins involved in this task, the tubulin-binding protein gephyrin plays a crucial role. Through its self-oligomerization properties, this protein forms hexagonal lattices that trap GABAA and glycine receptors and link them to the cytoskeleton. By directly interacting with cell-adhesion molecules of the neuroligin-neurexin families that connect presynaptic and postsynaptic neurons at synapses, gephyrin ensures a backward control of presynaptic signaling. In addition, changes in clusters size is dynamically regulated by lateral diffusion of neurotransmitter receptors between the synaptic and extrasynaptic compartments and by their interaction with synaptic scaffold proteins. The aim of this Research Topic (research articles and reviews) is to bring together experts on the cellular and molecular mechanisms regulating the appropriate assembly, location and function of pre and postsynaptic specializations at inhibitory synapses. A particular emphasis will be on the role of receptor trafficking in synaptic stabilization and plasticity.

The Synaptic Organization of the Brain
The Synaptic Organization of the Brain

Author: Gordon M. Shepherd

Publisher: Oxford University Press

Published: 2004

Total Pages: 736

ISBN-13: 019515956X

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This is a thorough revision of the standard text on local circuits in the different regions of the brain. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods.

Morpho-functional Machines: The New Species
Morpho-functional Machines: The New Species

Author: Fumio Hara

Publisher: Springer Science & Business Media

Published: 2003-06-05

Total Pages: 310

ISBN-13: 9784431703334

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Morpho-functional Machines are a set of tools for investigating the design of embodied intelligence in autonomous bio-artifact systems. The focus in Morpho-functional Machines is on the balance of morphology, materials, and control; intelligent behavior emerges from the interaction of an autonomous system with a real-world environment. How, then, should body morphology, body materials, and sensory systems be designed to achieve a certain set of tasks or desired behaviors in a particular environment? This and other questions were addressed at the International Workshop on Morpho-functional Machines held in Tokyo in 2001. Collected here are the revised papers from the workshop, providing a new perspective for understanding embodied intelligence. Presenting the innovative concept of Morpho-functional Machines, this book is a valuable source for scientists and engineers working in ethnology, cognitive sciences, robotic engineering, and artificial intelligence.

Excitation and Inhibition
Excitation and Inhibition

Author: Koji Uchizono

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 225

ISBN-13: 1483163938

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Excitation and Inhibition: Synaptic Morphology proposes the S-F hypothesis that emphasizes the relationship between structure and function of synapses. This book begins with an introduction to the notion of inhibition in the physiology of the nervous system and history of "synapse, followed by a discussion on the development of concept and morphological correlates of excitation and inhibition in relation to the S-F hypothesis. The mechanism of synaptic excitation and inhibition, physiological classification of neurons, and release mechanism of transmitters are also elaborated. This text describes the synaptic vesicles as a basis of transmitter, membrane recycle, transmission in the sympathetic ganglion, and transmitter substance. The criticism of S-F hypothesis, which deliberates the skeptical investigations of specialists regarding the simplicity and immaturity of the S-F hypothesis of synaptic morphology are provided at the end. This publication is beneficial to medical students and practitioners aiming to acquire knowledge of the physiology of synapses.

Atlas of Epilepsies
Atlas of Epilepsies

Author: S.R. Benbadis

Publisher: Springer Science & Business Media

Published: 2010-09-20

Total Pages: 1966

ISBN-13: 1848821271

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Atlas of Epilepsies is a landmark, all-encompassing, illustrated reference work and hands-on guide to the diagnosis, management and treatment of epilepsy in all its forms and across all age groups. The premier text in the field with over one thousand images, the Atlas’s highly illustrative approach tackles the difficult subject of epileptic seizures and epileptic syndromes, accompanied by sequential photographs of each management step. Intraoperative photographs are accompanied by detailed figure legends describing nuances, subtleties, and the thought processes involved in each step, providing a fuller understanding of each procedure. The Atlas draws on the expertise of over 300 internationally-renowned experts, and is liberally interspersed with clinical insights and personal vignettes that offer helpful tips, technical advice and critical knowledge to the clinician and scholar. The thorough and complete table of contents includes dedicated sections or chapters on important topics such as neonatal and pediatric seizures; imitators of epilepsy; EEG and neuroimaging; psychiatric and quality of life aspects of epilepsy; and a complete guide to treatment options including current and up-to-date chapters on pharmaceuticals, surgical procedures, and additional and alternative treatments. No other publication addresses epilepsies as thoroughly and completely as the Atlas of Epilepsies. Exhaustive and illustrative, convenient and current, this reference is sure to be the premier text on epilepsy for many years to come.