Susceptibility to Engineered Nanomaterial-Induced Toxicity in Mouse Models of Allergic Lung Disease
Author: Mark David Ihrie
Publisher:
Published: 2018
Total Pages: 117
ISBN-13:
DOWNLOAD EBOOKRead and Download eBook Full
Author: Mark David Ihrie
Publisher:
Published: 2018
Total Pages: 117
ISBN-13:
DOWNLOAD EBOOKAuthor: David K. Scoville
Publisher:
Published: 2017
Total Pages: 165
ISBN-13:
DOWNLOAD EBOOKNanotechnology is a global industry producing a large variety of engineered nanomaterials (ENMs) for use in virtually every industry sector. Quantum dots (QDs) are ENMs with attractive semiconductor and fluorescent properties and commonly consist of a cadmium and selenium (CdSe) core surrounded by a zinc sulfide (Zn/S) shell. QDs have applications in biomedical research and potentially medicine as imaging tools and have multiple uses in electronics and energy industries. Silver nanoparticles (AgNPs) are composed of silver atoms and sometimes include other metals such as gold. AgNPs have been incorporated into numerous products as an antimicrobial agent. While these ENMs have beneficial uses, they have been shown to induce lung inflammation and toxicity in rodent models following pulmonary exposures. However, most QD and AgNP toxicity studies to date have only used one strain of mouse or rat and thus have not addressed the role of genetic variability as a potential modulator of susceptibility. My dissertation was primarily focused on investigating the role of genetic background as a determinant of susceptibility to QD- and AgNP-induced lung inflammation and toxicity utilizing multi-strain mouse models. We found substantial inter-strain variation in susceptibility to QD- and AgNP-induced pulmonary inflammatory responses across the Collaborative Cross (CC) founder mouse strains. Over the last decade, the CC has created a panel of recombinant inbred (RI) mouse strains from eight genetically diverse founder strains to facilitate genetic mapping studies. Having established variability among the CC founder strains, we characterized the QD inflammatory response in a panel of CC RI inbred mouse strains in collaboration with researchers at the UNC. In collaboration with researchers at NYU we characterized the AgNP inflammatory response in 17 additional mouse strains (25 total strains). We used genome-wide association (GWA) mapping to identify genomic regions associated with QD- and AgNP-induced lung inflammation and toxicity containing candidate susceptibility genes that could modulate QD and AgNP responses and provide mechanistic insight. We also investigated the effects of QDs on lung mechanics and house dust mite (HDM) induced allergic airway disease in CC founder mouse strains we found initially to be more (A/J) and less (C57BL/6J) susceptible to QD-induced lung inflammation. Our results indicated that A/J mice were more susceptible to QD-induced changes lung mechanics. In addition, co-exposure to HDM+QDs enhanced cytokine production in A/J mice where HDM exposure alone did not result in significant increases and A/J mice had more lung type 2 innate lymphoid cells (ILC2s) than C57BL/6J mice. Significant inverse associations between glutathione and different endpoints across multiple studies highlighting the importance of redox balance in ENM induced lung inflammation and toxicity. The findings from these studies have important regulatory implications for ENMs in that genetic background of test animal strain is important to consider in risk models such that safety standards ensure adequate protection for sensitive populations.
Author: Muharrem Ince
Publisher: BoD – Books on Demand
Published: 2020-07-29
Total Pages: 232
ISBN-13: 178984696X
DOWNLOAD EBOOKBiochemical Toxicology - Heavy Metals and Nanomaterials provides an overview of biochemical contamination, nanomaterials and toxic metals, and measurement techniques. It explains and clarifies important studies and compares and develops new and groundbreaking measurement techniques in the fields of organic and inorganic pollution and nanoscience. It is highly recommended for professionals and readers interested in the environment and human health.
Author: David G. Capco
Publisher: Springer Science & Business Media
Published: 2014-03-28
Total Pages: 284
ISBN-13: 9401787395
DOWNLOAD EBOOKThe rapidly developing field of nanomaterials has expanded in many commercial areas. More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, including research into stem cells. Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues. While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function. In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer and an increasing number of new applications. This book investigates these areas and also includes new methods for assessment in cell biology and medicine.
Author: Bengt Fadeel
Publisher: Academic Press
Published: 2012-01-25
Total Pages: 367
ISBN-13: 0123869765
DOWNLOAD EBOOKAdverse Effects of Engineered Nanoparticles: A Disease-Oriented Approach provides a systematic evaluation of representative engineered nanomaterial (ENM) of high volume production and of high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies and the general public need to know about nanosafety. This book, written by leading international experts in nanotoxicology and nanmoedicine, gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers and patients. The beneficial applications, both diagnostic and therapeutic, of ENM are also highlighted. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, and the clinical and pathological consequences of such exposure in the human population. Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine Discusses the health implications and a clinical translation of experimental data in this area Takes a schematic, non-exhaustive approach to summarize the most important research data in this field Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book
Author: Elisabeth Heseltine
Publisher: WHO Regional Office Europe
Published: 2009
Total Pages: 247
ISBN-13: 9289041684
DOWNLOAD EBOOKMicrobial pollution is a key element of indoor air pollution. It is caused by hundreds of species of bacteria and fungi, in particular filamentous fungi (mould), growing indoors when sufficient moisture is available. This document provides a comprehensive review of the scientific evidence on health problems associated with building moisture and biological agents. The review concludes that the most important effects are increased prevalences of respiratory symptoms, allergies and asthma as well as perturbation of the immunological system. The document also summarizes the available information on the conditions that determine the presence of mould and measures to control their growth indoors. WHO guidelines for protecting public health are formulated on the basis of the review. The most important means for avoiding adverse health effects is the prevention (or minimization) of persistent dampness and microbial growth on interior surfaces and in building structures. [Ed.]
Author: Takemi Otsuki
Publisher: Springer
Published: 2016-10-12
Total Pages: 159
ISBN-13: 9811003513
DOWNLOAD EBOOKThis book offers a collection of the latest clinical and research findings related to allergies, one of the most frequently treated conditions in occupational medicine. The chapters not only cover asthma but also elaborate on contact dermatitis, rhinitis, and other allergic conditions, providing readers with a comprehensive overview of the substances disrupting autoimmunity and their effects on the human body. Allergy and Immunotoxicology in Occupational Health is a valuable resource for professionals and researchers in the occupational health sector, who will discover novel insights into immune effects, providing a foundation for future considerations of the health impairments caused by environmental and occupational exposure to these substances.
Author: Giovanni Parmigiani
Publisher: Springer Science & Business Media
Published: 2006-04-11
Total Pages: 511
ISBN-13: 0387216790
DOWNLOAD EBOOKThis book presents practical approaches for the analysis of data from gene expression micro-arrays. It describes the conceptual and methodological underpinning for a statistical tool and its implementation in software. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.
Author: James C. Bonner
Publisher: Springer Nature
Published: 2020-01-30
Total Pages: 229
ISBN-13: 3030339629
DOWNLOAD EBOOKThis book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.
Author: Kavindra Kumar Kesari
Publisher: Springer Nature
Published: 2022-03-11
Total Pages: 392
ISBN-13: 3030834468
DOWNLOAD EBOOKThe main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of free radical research and environmental toxicity. This book presents various state-of-the-art chapters of recent progress in the field of cellular toxicology and clinical manifestations of various disorders. Topics include cell signaling, various risk factors, the pathophysiology of disease instigation and distribution, mechanistic insights into metal and nanoparticle toxicity, neural toxicity, nongenotoxic carcinogenicity, immune and idiosyncratic toxicity, prevention, biomarkers related to disease progression and therapeutic strategies. In particular, this book provides valuable insight for researchers, pathologists, and clinicians with an interest in toxicological research and cellular impairments with special emphasis on therapeutic advancement.