The book is based on International Summer Schools on Biophysics held in Croatia which, contrary to other workshops centered mainly on one topic or technique, has very broad scope providing advanced training in areas related to biophysics. This volume presents papers in the field of biophysics for studying biological phenomena by using physical methods and/or concepts. Its scope should be of interest for students at doctoral or postdoctoral level and to experienced scientists.
This volume covers some powerful biophysical methods, such as analytical centrifugation, mass spectrometry, fluorescence spectroscopy, electron spin resonance and nuclear magnetic resonance, for the study of complex biological structures, and discusses useful physical concepts as applied to biological and biochemical systems. Case-orientated studies concentrating on particular methodologies are presented and examples are given, addressing some of the most important aspects of structure-function relationship in biological assemblies. Biophysics nowadays collaborates closely with molecular biology and bioinformatics and this is also demonstrated in this book. The book will be of interest both to experienced researchers wishing to widen their insight into molecular structure and function, and to younger scientists at the doctoral and postdoctoral level interested in the molecular nature of fundamental biological entities and phenomena.
Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki's book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. - Examines the evolutionary origins and consequences of the extracellular matrix - Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system - Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning - Provides an introduction to the properties and organization of the extracellular matrix components
Non-covalent interactions, which are the heart of supramolecular chemistry are also the basis of most important functions of living systems. The ability to apply supramolecular chemistry principles to the life sciences, such as designing synthetic host compounds to selectively interact within biological targets, has gained wide appeal due the vast number of potential applications. Supramolecular Systems for Biomedical Fields provides in sixteen chapters a comprehensive overview of these applications. Each chapter covers a specific topic and is written by internationally renowned experts in that area. Sensing of bioactive inorganic ions and organic substrates is the focus of several contributions, as well as interactions with proteins and nucleic acids. Specific chapters are devoted to cyclodextrins, calixarenes and cucurbiturils as most frequently used receptors, including applications such as drug delivery and protection, gene transfer and others. Other chapters address the use of combinatorial libraries, molecular imprinting techniques, enzyme assays, supramolecular gels, bioimaging, drug activation, photodynamic therapy, and antitumour metal complexes. This timely publication will appeal to graduate students and researchers from chemical, pharmaceutical, biological, and medicinal fields interested in the supramolecular chemistry of biological systems and their practical potentials.
The Handbook of Lipids in Human Nutrition is a concise reference for professionals and students interested in the role of lipids in nutrition. Over 100 tables and illustrations provide quick access to the most current data available.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant todaytruly an essential publication for researchers in all fields of life sciences.Key Features* Presents alternatives to mammalian model systems* Discusses virulence and essential gene identification* Defines global gene expression
Bacterial Endotoxic Lipopolysaccharides provides an up-to-date, two-volume review of the latest information regarding bacterial lipopolysaccharide structure and activities. These volumes cover the biochemistry, pharmacology, and pathophysiologic properties of endotoxins. The volumes also thoroughly discuss the strengths and weaknesses of new therapies for septic shock that are based on an immunological attack on endotoxins and the cytokines induced by endotoxins. All scientists involved in endotoxin research, clinical infectious disease specialists, and medical students interested in the pathogenesis of septic shock will find Bacterial Endotoxic Lipopolysaccharides invaluable as a reference resource.
While searching the syllabi for the spectral aspects of Inorganic compounds and metal complexes, we come across some important chapters in chemistry in almost all Universities in India and abroad. Laser Raman spectroscopy, Supramolecular chemistry, Nanochemistry and Sonochemistry are found either as separate papers or as chapters in a paper in B.Sc., M.Sc. and M.Phil. syllabi. So we thought of including these chapters along with the inorganic aspects of spectroscopy like Nuclear Quadrupole spectroscopy, ORD and CD of Inorganic compounds, Mass spectra of inorganic compounds and Photoelectron spectroscopy. The limited knowledge of Laser chemistry and Raman spectroscopy leads to the less understanding of Laser Raman spectroscopy. Hence chapters on Laser chemistry and Fundamentals of Raman spectroscopy are included in this book. These chapters were once considered as specialization in chemistry but due to advancement in chemistry, they find place in the regular curriculum. The book is written in a simple language with more advanced and latest informations. Diagrams and tables are given for the better understanding of the subject matter. The book provides a comprehensive and indepth coverage of the subject. There is a shortage of suitable text books for these chapters and this book may fill the gap and will mostly be useful to all the B.Sc. and M.Sc. students and M.Phil. Scholars globally. This book is an outcome of very long teaching and research experience of the authors in the field of Inorganic chemistry. Apart from the subject study, this book may also be used for writing the competitive examinations like UGC–NET, Civil Services Examination and so on. This book is also useful for the interdisciplinary students studying physics and biological sciences.
Application of NMR and Molecular Docking in Structure-Based Drug Discovery, by Jaime L. Stark and Robert Powers NMR as a Unique Tool in Assessment and Complex Determination of Weak Protein-Protein Interactions, by Olga Vinogradova and Jun Qin The Use of Residual Dipolar Coupling in Studying Proteins by NMR, by Kang Chen und Nico Tjandra NMR Studies of Metalloproteins, by Hongyan Li and Hongzhe Sun Recent Developments in 15N NMR Relaxation Studies that Probe Protein Backbone Dynamics, by Rieko Ishima Contemporary Methods in Structure Determination of Membrane Proteins by Solution NMR, by Tabussom Qureshi and Natalie K. Goto Protein Structure Determination by Solid-State NMR, by Xin Zhao Dynamic Nuclear Polarization: New Methodology and Applications, by Kong Hung Sze, Qinglin Wu, Ho Sum Tse and Guang Zhu
