Embryo adoptions, stem cells capable of transforming into any cell in the human body, intra- and inter-species organ transplantation—these and other biomedical advances have unsettled ideas of what it means to be human, of when life begins and ends. In the first study to consider the cultural impact of the medical transformation of the entire human life span, Susan Merrill Squier argues that fiction—particularly science fiction—serves as a space where worries about ethically and socially charged scientific procedures are worked through. Indeed, she demonstrates that in many instances fiction has anticipated and paved the way for far-reaching biomedical changes. Squier uses the anthropological concept of liminality—the state of being on the threshold of change, no longer one thing yet not quite another—to explore how, from the early twentieth century forward, fiction and science together have altered not only the concept of the human being but the contours of human life. Drawing on archival materials of twentieth-century biology; little-known works of fiction and science fiction; and twentieth- and twenty-first century U.S. and U.K. government reports by the National Institutes of Health, the Parliamentary Advisory Group on the Ethics of Xenotransplantation, and the President’s Council on Bioethics, she examines a number of biomedical changes as each was portrayed by scientists, social scientists, and authors of fiction and poetry. Among the scientific developments she considers are the cultured cell, the hybrid embryo, the engineered intrauterine fetus, the child treated with human growth hormone, the process of organ transplantation, and the elderly person rejuvenated by hormone replacement therapy or other artificial means. Squier shows that in the midst of new phenomena such as these, literature helps us imagine new ways of living. It allows us to reflect on the possibilities and perils of our liminal lives.
Cells and Tissues in Culture: Methods, Biology and Physiology, Volume 1 covers the general fields of tissue culture, including an evaluation of its technique, effects, and contributions to biology. This book focuses on the three methods of culture—tissue culture, cell culture, and organ culture.Other topics include the design of complete synthetic media, possible evolution of the cell types, and energy relationships in growing and stationary cells. The RNA synthesis in cell cultures, culture of amphibian embryonic anlage, action of corticosteroids and adrenaline, and effects of parathyroid hormone on bone are also elaborated. This volume is recommended for biologists and specialists interested in the culture of cells and tissues.
Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research
Differentiation and Immunology is a collection of papers that deals with molecular specificity—the link between immunology and differentiation. One paper reviews the status of regulation in bacteria or viruses, and extends the results to animal cells. The paper also investigates a single aspect of the control of immunoglobulin through the use of plasmacytomas. Another paper discusses the role of macrophages in the minimum theory to possibly account for the energetics of the reaction with receptors, or to the frequency of antigen-sensitive cells. Some papers investigate the immunogenic function of macrophages, the transition from monocyte to macrophage, the factors influencing the formation of macrophage lysosomes, and the origin of macrophage lysosomes. Other papers also discuss the immune response as a model system for studies on cellular differentiation, as well as the differentiation for collagen synthesis in cultured cells. One paper suggests that in differentiation, the changes that can occur in the properties of protozoan cells, perpetuated for long periods, are reversible, and can be a means for survival—as every cell line is also capable of being a germ line. This collection can prove valuable to bio-chemists, cellular biologists, micro-biologists, developmental biologists, and scientists involved in immunology research.
Breast Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Breast Cancer. The editors have built Breast Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Breast Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Breast Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Over the last 20 years it has become increasingly apparent that the occurrence of many cancers can have an inherited basis. This book examines the principles underlying genetic predisposition to cancer and will be relevant to practising oncologists, geneticists and other professionals interested in this rapidly expanding field. Coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the identification and characterisation of predisposition genes, to a consideration of heritable cancer syndromes, and encompasses both rare and common cancers. The text also features a discussion of cancer risk assessment, genetic counselling issues, genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. Building on the reputation of the previous edition, and to reflect the rapid advances in the field since its publication, the contents of the second edition have been thoroughly updated and include discussion of many newly identified cancer genes. In particular, the book features new chapters added on the biological basis of cancer predisposition, population-based studies of susceptibility, and evaluation of management strategies for individuals at increased cancer risk.