Stochastic Methods in Cancer Research. Applications to Genomics and Angiogenesis
Stochastic Methods in Cancer Research. Applications to Genomics and Angiogenesis

Author: Paola M. V. Rancoita

Publisher: Ledizioni

Published: 2011

Total Pages: 301

ISBN-13: 8895994582

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In this thesis, I study three stochastic methods that can be applied for the analysis of data in cancer research and, in particular, to cancer genomic data and to images of angiogenic processes. Cancer is a multistep process where the accumulation of genomic lesions alters cell biology. The latter is under control of several pathways and thus, cancer can arise via different mechanisms affecting different pathways. Due to the general complexity of this disease and the different types of tumors, the efforts of cancer research cover several research areas such as, for example, immunology, genetics, cell biology, angiogenesis.

Integrated Multidisciplinary Approaches in the Study and Care of the Human Eye
Integrated Multidisciplinary Approaches in the Study and Care of the Human Eye

Author: P. Causin

Publisher: Kugler Publications

Published: 2014-12-17

Total Pages: 198

ISBN-13: 9062992412

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ForewordThe human eye offers the extraordinary possibility to visualize and monitor non-invasively, in vivo, in humans, many morphological and haemodynamical features. Therefore, a large amount of data on ocular structures and macro- and micro-circulation can be obtained in a clinical setting during a patient's visit. However, the interpretation of these data remains a very challenging task, since the understanding of the physiology, bio-mechanics and fluid-dynamics of the human eye remains scarce. This unmet gap between the availability of imaging data and their elusive clinical interpretatio...

Non-overlapping Domain Decomposition Methods for Three-dimensional Cardiac Reaction-diffusion Models and Applications
Non-overlapping Domain Decomposition Methods for Three-dimensional Cardiac Reaction-diffusion Models and Applications

Author: Stefano Zampini

Publisher: Ledizioni

Published: 2011

Total Pages: 269

ISBN-13: 8895994663

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Recent advances in biotechnology and the availability of ever more powerful computers have led to the formulation of increasingly complex models at all levels of life sciences, in particular of cardiac electrophysiology. Multiscale modeling of the bioelectric activity of the heart, taking into account macroscopic (fiber architecture and anisotropy) and microscopic (cellular) features of the tissue, aim to develop predictive tools for future drug design and patient-specific therapies, using detailed and efficient three-dimensional solvers for the governing equations of tissue electrophysiology.

On Some Axiomatic Extensions of the Monoidal T-Norm Based Logic Mtl
On Some Axiomatic Extensions of the Monoidal T-Norm Based Logic Mtl

Author: Matteo Bianchi

Publisher: Ledizioni

Published: 2011

Total Pages: 169

ISBN-13: 8895994566

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The scientific area this thesis belongs to is many-valued logics: this meanslogics in which, from the semantical point of view, we have "intermediate"truth-values, between 0 and 1 (which in turns are designated to represent, respectively, the "false" and the "true").The classical logic (propositional, for simplicity) is based on the fact thatevery statement is true or false: this is reflected by the excluded middle law, that is a theorem of this logic. However, there are many reasons that suggestto reject this law: for example, intuitionistic logic does not satisfy it, sincethis logic reflects a "constructive" conception of mathematics (see [Hey71, Tro69]).

Progress in Industrial Mathematics at ECMI 2010
Progress in Industrial Mathematics at ECMI 2010

Author: Michael Günther

Publisher: Springer Science & Business Media

Published: 2012-04-05

Total Pages: 613

ISBN-13: 3642251005

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ECMI, the European Consortium for Mathematics in Industry, is the European brand associated with applied mathematics for industry and organizes highly successful biannual conferences. In this series, the ECMI 2010, the 16th European Conference on Mathematics for Industry, was held in the historic city hall of Wuppertal in Germany. It covered the mathematics of a wide range of applications and methods, from circuit and electromagnetic device simulation to model order reduction for chip design, uncertainties and stochastics, production, fluids, life and environmental sciences, and dedicated and versatile methods. These proceedings of ECMI 2010 emphasize mathematics as an innovation enabler for industry and business, and as an absolutely essential pre-requiste for Europe on its way to becoming the leading knowledge-based economy in the world.

Genome Chaos
Genome Chaos

Author: Henry H. Heng

Publisher: Academic Press

Published: 2019-05-25

Total Pages: 564

ISBN-13: 0128136367

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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. - Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine - Gathers the most pressing questions in genomic and cytogenomic research - Offers alternative explanations to timely puzzles in the field - Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more