Nucleic Acid Aptamers

Nucleic Acid Aptamers

Author: Günter Mayer

Publisher: Humana

Published: 2015-11-10

Total Pages: 0

ISBN-13: 9781493931965

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This volume provides protocol references covering recent developments in the aptamer field. Within the last decade, aptamers have become more and more popular, and their sophisticated biophysical properties together with their ability to be easily modified and, thus, adapted to various regimens makes them a very promising class of compounds. Divided into three sections, the book covers selection, a series of analytical methods to assess biophysical properties of aptamer-target interactions, as well as various applications of aptamers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and easy to follow, Nucleic Acid Aptamers: Selection, Characterization, and Application provides a state-of-the-art summary of recent developments in the aptamer field and will be a helpful resource for scientists in the life sciences working with aptamers as tools to elucidate biological systems.


Point-of-care testing

Point-of-care testing

Author: Peter Luppa

Publisher: Springer

Published: 2018-07-18

Total Pages: 451

ISBN-13: 3662544970

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The underlying technology and the range of test parameters available are evolving rapidly. The primary advantage of POCT is the convenience of performing the test close to the patient and the speed at which test results can be obtained, compared to sending a sample to a laboratory and waiting for results to be returned. Thus, a series of clinical applications are possible that can shorten the time for clinical decision-making about additional testing or therapy, as delays are no longer caused by preparation of clinical samples, transport, and central laboratory analysis. Tests in a POC format can now be found for many medical disciplines including endocrinology/diabetes, cardiology, nephrology, critical care, fertility, hematology/coagulation, infectious disease and microbiology, and general health screening. Point-of-care testing (POCT) enables health care personnel to perform clinical laboratory testing near the patient. The idea of conventional and POCT laboratory services presiding within a hospital seems contradictory; yet, they are, in fact, complementary: together POCT and central laboratory are important for the optimal functioning of diagnostic processes. They complement each other, provided that a dedicated POCT coordination integrates the quality assurance of POCT into the overall quality management system of the central laboratory. The motivation of the third edition of the POCT book from Luppa/Junker, which is now also available in English, is to explore and describe clinically relevant analytical techniques, organizational concepts for application and future perspectives of POCT. From descriptions of the opportunities that POCT can provide to the limitations that clinician’s must be cautioned about, this book provides an overview of the many aspects that challenge those who choose to implement POCT. Technologies, clinical applications, networking issues and quality regulations are described as well as a survey of future technologies that are on the future horizon. The editors have spent considerable efforts to update the book in general and to highlight the latest developments, e.g., novel POCT applications of nucleic acid testing for the rapid identification of infectious agents. Of particular note is also that a cross-country comparison of POCT quality rules is being described by a team of international experts in this field.


Quark Confinement And The Hadron Spectrum V, Proceedings Of The 5th International Conference

Quark Confinement And The Hadron Spectrum V, Proceedings Of The 5th International Conference

Author: Nora Serafina Brambilla

Publisher: World Scientific

Published: 2003-08-27

Total Pages: 551

ISBN-13: 9814485810

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This book provides an update on our understanding of strong interaction, with theoretical and experimental highlights included. It is divided into five sections. The first section is devoted to the investigations into and the latest results on the mechanism of quark confinement. The second and third sections focus respectively on light and heavy quarks (effective field theories, Schwinger-Dyson approach and lattice QCD results). The fourth section deals with the deconfinement mechanism and quark-gluon plasma formation signals. The last section presents highlights of experiments, new physics beyond QCD, and nonperturbative approaches in other theories (strings and SUSY) that may be useful in QCD.


Aptamers for Analytical Applications

Aptamers for Analytical Applications

Author: Yiyang Dong

Publisher: John Wiley & Sons

Published: 2019-02-11

Total Pages: 426

ISBN-13: 3527342672

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An essential guide that puts the focus on method developments and applications in aptamers In recent years, aptamer-based systems have been developed for a wide-range of analytical and medical applications. Aptamers for Analytical Applications offers an introduction to the topic, outlines the common protocols for aptamer synthesis, as well as providing information on the different optimization strategies that can obtain higher affinities to target molecules. The contributors?noted experts on the topic?provide an in-depth review of the characterization of aptamer-target molecule interaction and immobilization strategies and discuss the developments of methods for all the relevant applications. The book outlines different schemes to efficiently immobilize aptamers on substrates as well as summarizing the characterization methods for aptamer-ligand complexes. In addition, aptamer-based colorimetric, enzyme-linked, fluorescent, electrochemical, lateral flow and non-labeling analytical methods are presented. The book also reflects state-of-the-art and emerging applications of aptamer-based methods. This important resource: -Provides a guide to aptamers which provide highly specific and sensitive molecular recognition, with affinities in the range of antibodies and are much cheaper to produce -Offers a discussion of the analytical method developments and improvements with established systems and beyond -Offers a comprehensive guide to all the relevant application areas -Presents an authoritative book from contributors who are noted experts in the field Written for analytical chemists, biochemists, analytical researchers, Aptamers for Analytical Applications is a comprehensive book that adopts a methodological point of view to the important aspects of aptamer generation and modification with a strong emphasis on method developments for relevant applications.


Major Companies of the Arab World 1993/94

Major Companies of the Arab World 1993/94

Author: Giselle C Bricault

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 1084

ISBN-13: 9401114587

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This book represents the seventeenth edition of the leading IMPORTANT reference work MAJOR COMPANIES OF THE ARAB WORLD. All company entries have been entered in MAJOR COMPANIES OF THE ARAB WORLD absolutely free of ThiS volume has been completely updated compared to last charge, thus ensuring a totally objective approach to the year's edition. Many new companies have also been included information given. this year. Whilst the publishers have made every effort to ensure that the information in this book was correct at the time of press, no The publishers remain confident that MAJOR COMPANIES responsibility or liability can be accepted for any errors or OF THE ARAB WORLD contains more information on the omissions, or fqr the consequences thereof. major industrial and commercial companies than any other work. The information in the book was submitted mostly by the ABOUT GRAHAM & TROTMAN LTD companies themselves, completely free of charge. To all those Graham & Trotman Ltd, a member of the Kluwer Academic companies, which assisted us in our research operation, we Publishers Group, is a publishing organisation specialising in express grateful thanks. To all those individuals who gave us the research and publication of business and technical help as well, we are similarly very grateful. information for industry and commerce in many parts of the world.