Stem Cells and Cancer Stem Cells, Volume 12
Stem Cells and Cancer Stem Cells, Volume 12

Author: M.A. Hayat

Publisher: Springer Science & Business Media

Published: 2014-02-20

Total Pages: 284

ISBN-13: 9401780323

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Volume 12 in this series explores the latest experimental and clinical uses of stem cells in the treatment of disease and of injuries and reviews methods for isolating multipotent endothelial-like cells from human adipose tissue and discusses clinical applications in cell therapy and regenerative medicine. The book is organized in five parts: Cancer Stem Cells, Pluripotent Stem Cells, Dendritic Stem Cells, Regenerative Medicine and General Applications. The first section includes chapters on histamine in the neural and cancer stem cell niches and emerging concepts of stem cell organization in the normal lung and in lung cancer. The section on Pluripotent Stem Cells includes discussion of the differentiation of dendritic cells from human induced pluripotent stem cell and the molecular mechanisms involved in reprogramming human somatic cells to generate induced pluripotent stem cells. Additional chapters cover the differentiation of induced pluripotent stem cells into functional cardiomyocytes, characteristics of satellite cells and multipotent adult stem cells in the skeletal muscle. The section on Dendritic Stem Cells explores the critical role of notch signaling in the differentiation and function of dendrite. Other chapters cover hypertensive emergencies in children after stem cell transplantation and overcoming the radio resistance of lung cancer stem cells. The section on Regenerative Medicine reports on experiments on improved renal revascularization in pigs using stem cells and phenotypic correction of murine Hemophilia A using cell-based therapy. The concluding section, General Applications, discusses such topics as methods in mathematical modeling for stem cells, as well as molecular and functional characterization of human adipocytes. Like its eleven predecessors in the series, this volume stands out for its comprehensive approach, its roster of some 51 expert contributors representing a dozen different countries and its up-to-date review of leading-edge technology and methods.

Principles of Stem Cell Biology and Cancer
Principles of Stem Cell Biology and Cancer

Author: Tarik Regad

Publisher: John Wiley & Sons

Published: 2015-05-06

Total Pages: 378

ISBN-13: 1118670620

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Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Cancer Stem Cells
Cancer Stem Cells

Author: Vinagolu K. Rajasekhar

Publisher: John Wiley & Sons

Published: 2014-04-14

Total Pages: 0

ISBN-13: 9781118356166

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Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they're generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back to normal tissue stem cells. Each chapter begins with a brief historical note and concept summary, followed by a description of the latest basic or clinical advance associated with the topic. Cancer Stem Cells builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.

Handbook of Stem Cells
Handbook of Stem Cells

Author: Anthony Atala

Publisher: Academic Press

Published: 2012-12-31

Total Pages: 1076

ISBN-13: 0123859433

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New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells and Cell Biology and Adult and Fetal Stem Cells, this work contains contributions from the world's experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system. - Provides comprehensive coverage on this highly topical subject - Contains contributions by the foremost authorities and premiere names in the field of stem cell research - Companion website - http://booksite.elsevier.com/9780123859426/ - contains over 250 color figures in presentation format

The Heterogeneity of Cancer Metabolism
The Heterogeneity of Cancer Metabolism

Author: Anne Le

Publisher: Springer

Published: 2018-06-26

Total Pages: 186

ISBN-13: 331977736X

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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Stem Cells
Stem Cells

Author: Christine L. Mummery

Publisher: Academic Press

Published: 2014-05-23

Total Pages: 446

ISBN-13: 0124115675

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The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. - Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy - Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice - Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

The Cancer Stem Cell Niche
The Cancer Stem Cell Niche

Author: Susie Nilsson

Publisher: Academic Press

Published: 2021-02-09

Total Pages: 246

ISBN-13: 0323853250

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The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Trends in Stem Cell Proliferation and Cancer Research
Trends in Stem Cell Proliferation and Cancer Research

Author: Rodrigo R. Resende

Publisher: Springer Science & Business Media

Published: 2013-08-13

Total Pages: 663

ISBN-13: 9400762119

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The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Stem Cells
Stem Cells

Author: C. Potten

Publisher: Elsevier

Published: 1996-10-09

Total Pages: 497

ISBN-13: 0080541763

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Stem cells are relatively undifferentiated cells which are the permanent lineage ancestor cells of tissues. Newly developed molecular biological techniques and probes have made possible dramatic advances in our ability to study the lineage development of stem cells. A major impetus to develop these techniques has been to identify specific stem cells for gene therapy purposes. The role that stem cells play in the development of cancer is also an important area. This book provides up-to-date reviews on a wide variety of stem cell systems by world experts. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest. It will also be usefule to radiobiologist, biotechnologists, and gene therapists. - Provides reviews of stem cell systems by world experts - Covers stem cell biology in plants, invertebrates, and mammals - Presents clinical implications of stem cell differentiation

Stem Cells and Cancer Stem Cells, Volume 13
Stem Cells and Cancer Stem Cells, Volume 13

Author: M.A. Hayat

Publisher: Springer

Published: 2015-10-26

Total Pages: 159

ISBN-13: 9401772339

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This is the thirteenth volume in a series which presents current understanding of stem cells and cancer stem cells. This book presents many relevant topics including the different sources of cancer stem cells: the features, roles and clinical potential of stem cells emerge from engaging with this comprehensive work. Chapters explore molecular mechanisms underlying human somatic cell reprogramming to generate induced pluripotent stem cells and provide expert discussion of the advantages and limitations of applications of some of the stem cell types (pluripotent stem cells, neural stem cells). Many advances are explored, including the importance of stem cell markers in diagnosis, the role of stem cells in angiogenesis and a method for isolating multi potent endothelial-like cells from human adipose tissue, to name a few. Readers will also find a consideration of mathematical models and other quantitative tools which could facilitate research and discovery in the field. The editor’s preface to the book and the series is particularly helpful in introducing the work presented in this volume. The detailed overviews, practical experience and insights of international expert authors presented in this handbook will be of value to both professional practitioners and scholars in basic research.