The papers in this volume discuss important methodological advances in several important areas, including multivariate failure time data and interval censored data. The book will be an indispensable reference for researchers and practitioners in biostatistics, medical research, and the health sciences.
This book assembles papers which were presented at the biennial sympo sium in Computational Statistics held und er the a!uspices of the International Association for Statistical Computing (IASC), a section of ISI, the Interna tional Statistical Institute. This symposium named COMPSTAT '94 was organized by the Statistical Institutes of the University of Vienna and the University of Technology of Vienna, Austria. The series of COMPSTAT Symposia started 1974 in Vienna. Mean while they took place every other year in Berlin (Germany, 1976), Leiden (The Netherlands, 1978), Edinburgh (Great Britain, 1980), Toulouse (France, 1982), Prague (Czechoslovakia, 1984), Rom (Italy, 1986), Copenhagen (Den mark, 1988), Dubrovnik (Yugoslavia, 1990) and Neuchätel (Switzerland, 1992). This year we are celebrating the 20th anniversary in Vienna, Austria. It has obviously been observed a movement from "traditional" computa tional statistics with emphasis on methods which produce results quickly and reliably, to computationally intensive methods like resampling procedures, Bayesian methods, dynamic graphics, to very recent areas like neural net works, accentuation on spatial statistics, huge data sets, analysis strategies, etc. For the organization of the symposium, new guidelines worked out by the IASC in written form were in effect this time. The goal was to refresh somehow the spirit of the start of COMPSTAT '74, keep the tradition of the series and ensure a certain continuity in the sequence of biannual meetings.
Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.
This contributed volume offers a much-needed overview of the statistical methods in early clinical drug and biomarker development. Chapters are written by expert statisticians with extensive experience in the pharmaceutical industry and regulatory agencies. Because of this, the data presented is often accompanied by real world case studies, which will help make examples more tangible for readers. The many applications of statistics in drug development are covered in detail, making this volume a must-have reference. Biomarker development and early clinical development are the two critical areas on which the book focuses. By having the two sections of the book dedicated to each of these topics, readers will have a more complete understanding of how applying statistical methods to early drug development can help identify the right drug for the right patient at the right dose. Also presented are exciting applications of machine learning and statistical modeling, along with innovative methods and state-of-the-art advances, making this a timely and practical resource. This volume is ideal for statisticians, researchers, and professionals interested in pharmaceutical research and development. Readers should be familiar with the fundamentals of statistics and clinical trials.
This book reviews important topics in osteoporosis, with the emphasis on both clinical management and basic research of the disease. From the clinical perspective, topics covering pathogenesis, diagnosis, and treatment of osteoporosis are extensively elaborated. Several more chapters complement clinical overview of osteoporosis, that discuss the effects of nutrition and exercise to bone health, the application of biochemical markers in osteoporosis diagnosis, novel potential drug targets for osteoporosis treatment, and osteoporosis in males and in children. As the prevalence of osteoporosis now reaches epidemiological levels, epidemiology and social impacts of osteoporosis is also reviewed in the book. Basic research on osteoporosis is also highlighted in the book, with a number of chapters dedicated to the review of genetics of osteoporosis, animal models for osteoporosis, and statistical methods in osteoporosis study.
Survival analysis generally deals with analysis of data arising from clinical trials. Censoring, truncation, and missing data create analytical challenges and the statistical methods and inference require novel and different approaches for analysis. Statistical properties, essentially asymptotic ones, of the estimators and tests are aptly handled in the counting process framework which is drawn from the larger arm of stochastic calculus. With explosion of data generation during the past two decades, survival data has also enlarged assuming a gigantic size. Most statistical methods developed before the millennium were based on a linear approach even in the face of complex nature of survival data. Nonparametric nonlinear methods are best envisaged in the Machine Learning school. This book attempts to cover all these aspects in a concise way. Survival Analysis offers an integrated blend of statistical methods and machine learning useful in analysis of survival data. The purpose of the offering is to give an exposure to the machine learning trends for lifetime data analysis. Features: Classical survival analysis techniques for estimating statistical functional and hypotheses testing Regression methods covering the popular Cox relative risk regression model, Aalen’s additive hazards model, etc. Information criteria to facilitate model selection including Akaike, Bayes, and Focused Penalized methods Survival trees and ensemble techniques of bagging, boosting, and random survival forests A brief exposure of neural networks for survival data R program illustration throughout the book
The book presents a long list of useful methods for classification, clustering and data analysis. By combining theoretical aspects with practical problems, it is designed for researchers as well as for applied statisticians and will support the fast transfer of new methodological advances to a wide range of applications.
Although no-one is, probably, too enthused about the idea, it is a fact that the development of most empirical sciences to a great extend depends of the development of data analysis methods and techniques, which, due to the necessity of applications of computers for that pur pose, actually means that it practically depends on the advancements and orientation of computational statistics. This volume contains complete texts of the lectures held during the Summer School on "Computational Aspects of Model Choice" orga nized jointly by Charles University, Prague, and International Associa tion for Statistical Computing (IASC) on July 1-14, 1991, in Prague. Main aims of the Summer School were to review and analyse some of the recent developments concerning computational aspects of the model choice as well as their theoretical background. The topics covers the problems of the change point detection, robust estimation and its computational aspects, classification using binary trees, stochastic ap proximation and optimization including the discussion about available software, computational aspects of graphical model selection and mul tiple hypotheses testing. The bridge between these different approaches is formed by the survey paper about statistical applications of artificial intelligence.
