High-Dimensional Data Analysis in Cancer Research
High-Dimensional Data Analysis in Cancer Research

Author: Xiaochun Li

Publisher: Springer Science & Business Media

Published: 2008-12-19

Total Pages: 164

ISBN-13: 0387697659

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Multivariate analysis is a mainstay of statistical tools in the analysis of biomedical data. It concerns with associating data matrices of n rows by p columns, with rows representing samples (or patients) and columns attributes of samples, to some response variables, e.g., patients outcome. Classically, the sample size n is much larger than p, the number of variables. The properties of statistical models have been mostly discussed under the assumption of fixed p and infinite n. The advance of biological sciences and technologies has revolutionized the process of investigations of cancer. The biomedical data collection has become more automatic and more extensive. We are in the era of p as a large fraction of n, and even much larger than n. Take proteomics as an example. Although proteomic techniques have been researched and developed for many decades to identify proteins or peptides uniquely associated with a given disease state, until recently this has been mostly a laborious process, carried out one protein at a time. The advent of high throughput proteome-wide technologies such as liquid chromatography-tandem mass spectroscopy make it possible to generate proteomic signatures that facilitate rapid development of new strategies for proteomics-based detection of disease. This poses new challenges and calls for scalable solutions to the analysis of such high dimensional data. In this volume, we will present the systematic and analytical approaches and strategies from both biostatistics and bioinformatics to the analysis of correlated and high-dimensional data.

Statistical Modeling in Biomedical Research
Statistical Modeling in Biomedical Research

Author: Yichuan Zhao

Publisher: Springer Nature

Published: 2020-03-19

Total Pages: 495

ISBN-13: 3030334163

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This edited collection discusses the emerging topics in statistical modeling for biomedical research. Leading experts in the frontiers of biostatistics and biomedical research discuss the statistical procedures, useful methods, and their novel applications in biostatistics research. Interdisciplinary in scope, the volume as a whole reflects the latest advances in statistical modeling in biomedical research, identifies impactful new directions, and seeks to drive the field forward. It also fosters the interaction of scholars in the arena, offering great opportunities to stimulate further collaborations. This book will appeal to industry data scientists and statisticians, researchers, and graduate students in biostatistics and biomedical science. It covers topics in: Next generation sequence data analysis Deep learning, precision medicine, and their applications Large scale data analysis and its applications Biomedical research and modeling Survival analysis with complex data structure and its applications.

Data Analysis
Data Analysis

Author: Peter J. Huber

Publisher: John Wiley & Sons

Published: 2012-01-09

Total Pages: 267

ISBN-13: 1118018265

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This book explores the many provocative questions concerning the fundamentals of data analysis. It is based on the time-tested experience of one of the gurus of the subject matter. Why should one study data analysis? How should it be taught? What techniques work best, and for whom? How valid are the results? How much data should be tested? Which machine languages should be used, if used at all? Emphasis on apprenticeship (through hands-on case studies) and anecdotes (through real-life applications) are the tools that Peter J. Huber uses in this volume. Concern with specific statistical techniques is not of immediate value; rather, questions of strategy – when to use which technique – are employed. Central to the discussion is an understanding of the significance of massive (or robust) data sets, the implementation of languages, and the use of models. Each is sprinkled with an ample number of examples and case studies. Personal practices, various pitfalls, and existing controversies are presented when applicable. The book serves as an excellent philosophical and historical companion to any present-day text in data analysis, robust statistics, data mining, statistical learning, or computational statistics.

Registries for Evaluating Patient Outcomes
Registries for Evaluating Patient Outcomes

Author: Agency for Healthcare Research and Quality/AHRQ

Publisher: Government Printing Office

Published: 2014-04-01

Total Pages: 385

ISBN-13: 1587634333

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This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Statistical Modeling for Biomedical Researchers
Statistical Modeling for Biomedical Researchers

Author: William D. Dupont

Publisher: Cambridge University Press

Published: 2009-02-12

Total Pages: 543

ISBN-13: 0521849527

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A second edition of the easy-to-use standard text guiding biomedical researchers in the use of advanced statistical methods.

Latent Variable Models and Factor Analysis
Latent Variable Models and Factor Analysis

Author: David J. Bartholomew

Publisher: Wiley

Published: 1999-08-10

Total Pages: 214

ISBN-13: 9780340692431

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Hitherto latent variable modelling has hovered on the fringes of the statistical mainstream but if the purpose of statistics is to deal with real problems, there is every reason for it to move closer to centre stage. In the social sciences especially, latent variables are common and if they are to be handled in a truly scientific manner, statistical theory must be developed to include them. This book aims to show how that should be done. This second edition is a complete re-working of the book of the same name which appeared in the Griffin’s Statistical Monographs in 1987. Since then there has been a surge of interest in latent variable methods which has necessitated a radical revision of the material but the prime object of the book remains the same. It provides a unified and coherent treatment of the field from a statistical perspective. This is achieved by setting up a sufficiently general framework to enable the derivation of the commonly used models. The subsequent analysis is then done wholly within the realm of probability calculus and the theory of statistical inference. Numerical examples are provided as well as the software to carry them out ( where this is not otherwise available). Additional data sets are provided in some cases so that the reader can aquire a wider experience of analysis and interpretation.

Sample Size Calculations in Clinical Research
Sample Size Calculations in Clinical Research

Author: Shein-Chung Chow

Publisher: CRC Press

Published: 2017-08-15

Total Pages: 825

ISBN-13: 1351727117

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Praise for the Second Edition: "... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." – Journal of the Royal Statistical Society Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation. Features: Compares the relative merits and disadvantages of statistical methods for sample size calculations Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.

Business and Consumer Analytics: New Ideas
Business and Consumer Analytics: New Ideas

Author: Pablo Moscato

Publisher: Springer

Published: 2019-05-30

Total Pages: 1000

ISBN-13: 3030062228

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This two-volume handbook presents a collection of novel methodologies with applications and illustrative examples in the areas of data-driven computational social sciences. Throughout this handbook, the focus is kept specifically on business and consumer-oriented applications with interesting sections ranging from clustering and network analysis, meta-analytics, memetic algorithms, machine learning, recommender systems methodologies, parallel pattern mining and data mining to specific applications in market segmentation, travel, fashion or entertainment analytics. A must-read for anyone in data-analytics, marketing, behavior modelling and computational social science, interested in the latest applications of new computer science methodologies. The chapters are contributed by leading experts in the associated fields.The chapters cover technical aspects at different levels, some of which are introductory and could be used for teaching. Some chapters aim at building a common understanding of the methodologies and recent application areas including the introduction of new theoretical results in the complexity of core problems. Business and marketing professionals may use the book to familiarize themselves with some important foundations of data science. The work is a good starting point to establish an open dialogue of communication between professionals and researchers from different fields. Together, the two volumes present a number of different new directions in Business and Customer Analytics with an emphasis in personalization of services, the development of new mathematical models and new algorithms, heuristics and metaheuristics applied to the challenging problems in the field. Sections of the book have introductory material to more specific and advanced themes in some of the chapters, allowing the volumes to be used as an advanced textbook. Clustering, Proximity Graphs, Pattern Mining, Frequent Itemset Mining, Feature Engineering, Network and Community Detection, Network-based Recommending Systems and Visualization, are some of the topics in the first volume. Techniques on Memetic Algorithms and their applications to Business Analytics and Data Science are surveyed in the second volume; applications in Team Orienteering, Competitive Facility-location, and Visualization of Products and Consumers are also discussed. The second volume also includes an introduction to Meta-Analytics, and to the application areas of Fashion and Travel Analytics. Overall, the two-volume set helps to describe some fundamentals, acts as a bridge between different disciplines, and presents important results in a rapidly moving field combining powerful optimization techniques allied to new mathematical models critical for personalization of services. Academics and professionals working in the area of business anyalytics, data science, operations research and marketing will find this handbook valuable as a reference. Students studying these fields will find this handbook useful and helpful as a secondary textbook.

High-dimensional Data Analysis
High-dimensional Data Analysis

Author: Tony Cai;Xiaotong Shen

Publisher:

Published:

Total Pages: 318

ISBN-13: 9787894236326

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Over the last few years, significant developments have been taking place in highdimensional data analysis, driven primarily by a wide range of applications in many fields such as genomics and signal processing. In particular, substantial advances have been made in the areas of feature selection, covariance estimation, classification and regression. This book intends to examine important issues arising from highdimensional data analysis to explore key ideas for statistical inference and prediction. It is structured around topics on multiple hypothesis testing, feature selection, regression, cla.

Handbook of Data Visualization
Handbook of Data Visualization

Author: Chun-houh Chen

Publisher: Springer Science & Business Media

Published: 2007-12-18

Total Pages: 932

ISBN-13: 3540330372

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Visualizing the data is an essential part of any data analysis. Modern computing developments have led to big improvements in graphic capabilities and there are many new possibilities for data displays. This book gives an overview of modern data visualization methods, both in theory and practice. It details modern graphical tools such as mosaic plots, parallel coordinate plots, and linked views. Coverage also examines graphical methodology for particular areas of statistics, for example Bayesian analysis, genomic data and cluster analysis, as well software for graphics.