Skin Cancer and UV Radiation
Skin Cancer and UV Radiation

Author: Peter Altmeyer

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 1476

ISBN-13: 3642607713

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UV radiation is recognized as the major risk factor for skin can cer. For the last three decades the incidence and mortality of skin cancer have been increasing steadily in almost all parts of the world. Unfortunately, there have been very few advances in the management and treatment of skin cancer. In comparison to other malignant tumors, skin cancer offers the unique opportuni ty to identify this tumor at an early stage. Thus, there is strong interest in preventing death by early diagnosis and prompt treat ment. The proceedings of the International Congress on Skin Cancer and UV Radiation which was held in Bochum Germany in October 1996, reflect the newest scientific standards in the field of skin cancer. The conference in Bochum was a platform for leading scientists from all over the world to discuss the complexity and diversity of UV radiation in its interaction with the skin. Starting with basic science like physiology, immunology, and molecular biochemistry of the skin as influenced by UV radiati on, the book presents a profound survey into the field of skin can cer by focusing on the latest scientific results in prevention, early detection, treatment, and epidemiology. The congress in Bochum in 1996 was organized to provide a starting point for coordinated European strategies against skin cancer with internationally renown scientists.

Contemporary Heart Transplantation
Contemporary Heart Transplantation

Author: Linda Bogar

Publisher: Springer

Published: 2020-09-10

Total Pages: 0

ISBN-13: 9783319580531

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This work provides a one-of- a-kind volume that includes all aspects of heart transplantation from its historic beginning to its current day standards which now make the procedure a long-term treatment option for heart failure patients. The subjects covered include technical aspects of the procurement and implant procedures, as well as the medical nuances of pre-operative preparation and post-transplant immunosuppression management; the current day multi-disciplinary make up of the transplant team along with information on the keys to building and running a successful transplant program; regulatory standards and listing policies and the impact of the growing mechanical circulatory support technologies on the transplant field; and emerging technologies and future possibilities. All chapters are written by experts in the field and include the most up-to-date peer reviewed studies and clinical guidelines. This book gives an ever-changing reference that will become the text of choice for those beginning or continuing their transplant careers.

Skin Cancer Management
Skin Cancer Management

Author: Deborah MacFarlane

Publisher: Springer Science & Business Media

Published: 2010-03-11

Total Pages: 309

ISBN-13: 0387884955

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The editor of Skin Cancer Management: A Practical Approach, Dr. Deborah MacFarlane, gathers experts in selected techniques related to the assessment and management of skin cancer and has them critically review the existing literature in light of their considerable experience delivering care. The authors make recommendations for the best way to perform procedures. The tables provided in each chapter then become a manual of how to perform these procedures, and may in time be adopted by the wider universe of dermatologists as the standard of performance. The detailed descriptions of technique and treatment pearls lead the novice through the sequence of events in a way that instills confidence in their ability to safely perform the procedure. An example of the painstaking expla- tions is found in Chapter 5, Intralesional and Perilesional Treatment of Skin Cancers. The reader is advised to place eye protection on the patient and those performing the injection of methotrexate into a keratoacanthoma with a central crust. Rest assured that there will be a spray or stream of methotrexate emitted from the crusted area. Having eye protection will prevent methotrexate from accidentally getting into someone’s eye. Since we all learn to assimilate new information by taking action on the recommendations that we read, it would be a good idea for the physician to create, where relevant, a checklist for each procedure in the text. The checklist can be given to the office staff to set up the equipment for the procedure.

Dermatology and Solid Organ Transplantation
Dermatology and Solid Organ Transplantation

Author: Nathalie C. Zeitouni

Publisher: CRC Press

Published: 2021-08-15

Total Pages: 395

ISBN-13: 1000415929

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This textbook brings together experts in the field of transplant dermatology to review both state of the art and practical knowledge regarding the clinical presentation and management of the various cutaneous diseases seen in patients with solid organ transplant. Practicing dermatologists, trainees, and other health care providers involved in the care of transplant patients can learn the current diagnostic and management options, and how to apply these guidelines and principles in their everyday practice.

Sunlight, Vitamin D and Skin Cancer
Sunlight, Vitamin D and Skin Cancer

Author: Jörg Reichrath

Publisher: Springer Nature

Published: 2020-09-11

Total Pages: 428

ISBN-13: 3030462277

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The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Pediatric Solid Organ Transplantation
Pediatric Solid Organ Transplantation

Author: Richard N. Fine

Publisher: John Wiley & Sons

Published: 2009-04-08

Total Pages: 488

ISBN-13: 1444312731

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Pediatric Solid Organ Transplantation is acomprehensive and succinct text on all aspects of pediatric solidorgan transplantation. It provides a ready source of reference, toboth the basic science and organ specific surgical technique andafter care. This second edition has been extensively updated inlight of recent developments in this rapidly advancing area. The only textbook devoted to the field of pediatrictransplantation A definitive reference for all those interested in improvingthe care and quality of life of children undergoing solid organtransplantation Section on immunosuppression has been expanded by four chaptersto include sections on; - mechanisms of action - therapies for the sensitized patient - post-transplant lymphoproliferative disorders - organ toxicities of immunosuppressive therapy A new section has been added on the many topics related toquality of life that effect survivors of pediatrictransplantation International editorial and contributor team represents a widegeographical range and contains both recognized leaders andemerging experts Whether you are an established sub-specialist in pediatrictransplantation, a transplant surgeon, or a pediatric specialist ina related area, this book will answer all your questions about careof the pediatric patient before, during, and aftertransplantation.

Therapeutic Immunosuppression
Therapeutic Immunosuppression

Author: Angus W. Thomson

Publisher: Springer Science & Business Media

Published: 2001

Total Pages: 534

ISBN-13: 9780792368892

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This work has broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (for example, rheumatoid arthritis), skin disease and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area.

Chalk Talks in Internal Medicine
Chalk Talks in Internal Medicine

Author: Somnath Mookherjee

Publisher: Springer Nature

Published: 2020-09-30

Total Pages: 347

ISBN-13: 3030348148

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This book provides teaching scripts for medical educators in internal medicine and coaches them in creating their own teaching scripts. Every year, thousands of attending internists are asked to train the next generation of physicians to master a growing body of knowledge. Formal teaching time has become increasingly limited due to rising clinical workload, medical documentation requirements, duty hour restrictions, and other time pressures. In addition, today’s physicians-in-training expect teaching sessions that deliver focused, evidence-based content that is integrated into clinical workflow. In keeping with both time pressures and trainee expectations, academic internists must be prepared to effectively and efficiently teach important diagnostic and management concepts. A teaching script is a methodical and structured plan that aids in effective teaching. The teaching scripts in this book anticipate learners’ misconceptions, highlight a limited number of teaching points, provide evidence to support the teaching points, use strategies to engage the learners, and provide a cognitive scaffold for teaching the topic that the teacher can refine over time. All divisions of internal medicine (e.g. cardiology, rheumatology, and gastroenterology) are covered and a section on undifferentiated symptom-based presentations (e.g. fatigue, fever, and unintentional weight loss) is included. This book provides well-constructed teaching scripts for commonly encountered clinical scenarios, is authored by experienced academic internists and allows the reader to either implement them directly or modify them for their own use. Each teaching script is designed to be taught in 10-15 minutes, but can be easily adjusted by the reader for longer or shorter talks. Teaching Scripts in Internal Medicine is an ideal tool for internal medicine attending physicians and trainees, as well as physician’s assistants, nurse practitioners, and all others who teach and learn internal medicine.

High-Risk Cutaneous Squamous Cell Carcinoma
High-Risk Cutaneous Squamous Cell Carcinoma

Author: Chrysalyne D. Schmults

Publisher: Springer

Published: 2016-04-29

Total Pages: 261

ISBN-13: 3662470810

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This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.​

Skin Cancer after Organ Transplantation
Skin Cancer after Organ Transplantation

Author: Eggert Stockfleth

Publisher: Springer Science & Business Media

Published: 2009-05-05

Total Pages: 492

ISBN-13: 0387785744

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Organ transplantation has been performed for almost 40 years with steadily increasing success regarding long-time survival of the graft, as well as quality of life for the patient. However, graft tolerance only can be achieved via induction and maintenance of an impaired immunological surveillance. An increase of skin cancers as a consequence of the lowered cellular immunoresponse seems to parallel the overall increased long-time survival rate of organ transplant recipients. Against the background of chronic immunosuppression known risk factors like the amount of sun exposure prior and post transplantation, oncogenic viruses as well as the genetic background, and place of residence (latitude) are strongly related with the increased skin cancer incidence. The increasing incidence of non-melanoma skin cancer, paralleling a prolonged survival of patients after organ transplantation, represents a significant reason for morbidity and long-term morbidity in organ transplant recipients worldwide. The incidence of non-melanoma skin cancer in liver-, kidney- and heart transplant recipients varies from 1.5 to 22 %, 2 to 24 % and 6 to 34 % after 5 years post transplant. Ultraviolet radiation as well as immunosuppressive therapy are crucial risk-factors regarding the induction and progression of skin cancer. Ultraviolet radiation is related to the induction of DNA damage, as well as interference with Langerhans cell antigen presentation and a Th1 – Th2 shift induced via a release of IL-10. Whereas the overall duration of immunosuppression and the cumulative dosage applied are relevant parameters in the evaluation of an increased tumor risk, individual differences between specific immunosuppressive agents remain unclear. The workup of genetic as well as other unclear phenomenon like the reverse BCC/SCC ratio might shed some further light into the genesis and immunology of the non-melanoma skin cancer in general.