Selective Serotonin Reuptake Inhibitors (SSRIs) for Major Depression
Selective Serotonin Reuptake Inhibitors (SSRIs) for Major Depression

Author: Evelinda Trindade

Publisher:

Published: 1997

Total Pages: 130

ISBN-13:

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162 randomized controlled trials that compare selective serotonin reuptake inhibitors (SSRIs) to placebo or other antidepressants were reviewed. Meta-analyses were undertaken to compare 1) efficacy, 2) completion rates, and 3) adverse effects of individual drugs and drug classes. Efficacy was not statistically significantly different among individual SSRIs or between SSRIs as a group and tricyclic antidepressants (TCAs) or other antidepressants. SSRIs were significantly more efficacious than placebo. Completion rates were not statistically significantly different among individual SSRIs or between SSRIs as a group and TCAs or other antidepressants. Completion rates with SSRIs were significantly better than with placebo. Differences in drop-outs (between SSRIs and TCAs) due to lack of effect or worsening of symptoms were not statistically significantly different. Neither were the differences in drop-out rates due to adverse events, except when adult and outpatient group were combined. SSRIs were shown to be associated with statistically significantly more: nausea, anorexia, diarrhea, anxiety, agitation, insomnia and nervousness than TCAs. On the other hand, patients on SSRIs have statistically significantly fewer rates of: dry mouth, constipation, blurred vision and dizziness than with TCAs.

Depression and Heart Disease
Depression and Heart Disease

Author: Alexander Glassman

Publisher: John Wiley & Sons

Published: 2011-06-20

Total Pages: 110

ISBN-13: 1119957621

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Recently, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. Patients with psychiatric problems, particularly depression, may be more susceptible to cardiovascular disorders. Depression and Heart Disease synthesizes current evidence, including some previously unpublished data, in a concise, easy-to-read format. The authors succinctly describe the epidemiology, pathogenesis (including cytokines and genetics), and risk factors of the comorbidity between depression and heart disease. The book also reviews the best pharmacological and psychotherapeutic approaches for people with this comorbidity.

Fluoxetine
Fluoxetine

Author: Graziano Pinna

Publisher:

Published: 2015-04-01

Total Pages: 412

ISBN-13: 9781634820769

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Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.

DSM-5 Classification
DSM-5 Classification

Author: American Psychiatric Association

Publisher: American Psychiatric Publishing

Published: 2015-08-25

Total Pages: 0

ISBN-13: 9780890425664

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This handy DSM-5(R) Classification provides a ready reference to the DSM-5 classification of disorders, as well as the DSM-5 listings of ICD-9-CM and ICD-10-CM codes for all DSM-5 diagnoses. To be used in tandem with DSM-5(R) or the Desk Reference to the Diagnostic Criteria From DSM-5(R), the DSM-5(R) Classification makes accessing the proper diagnostic codes quick and convenient. With the advent of ICD-10-CM implementation in the United States on October 1, 2015, this resource provides quick access to the following: - The DSM-5(R) classification of disorders, presented in the same sequence as in DSM-5(R), with both ICD-9-CM and ICD-10-CM codes. All subtypes and specifiers for each DSM-5(R) disorder are included.- An alphabetical listing of all DSM-5 diagnoses with their associated ICD-9-CM and ICD-10-CM codes.- Separate numerical listings according to the ICD-9-CM codes and the ICD-10-CM codes for each DSM-5(R) diagnosis.- For all listings, any codable subtypes and specifiers are included with their corresponding ICD-9-CM or ICD-10-CM codes, if applicable. The easy-to-use format will prove indispensable to a diverse audience--for example, clinicians in a variety of fields, including psychiatry, primary care medicine, and psychology; coders working in medical centers and clinics; insurance companies processing benefit claims; individuals conducting utilization or quality assurance reviews of specific cases; and community mental health organizations at the state or county level.

A Guide To Treatments that Work
A Guide To Treatments that Work

Author: Peter Nathan

Publisher: Oxford University Press

Published: 2002-01-18

Total Pages: 705

ISBN-13: 0199760985

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A fully revised and updated edition of this unique and authoritative reference The award-winning A Guide to Treatments that Work , published in 1998, was the first book to assemble the numerous advances in both clinical psychology and psychiatry into one accessible volume. It immediately established itself as an indispensable reference for all mental health practitioners. Now in a fully updated edition,A Guide to Treatments that Work, Second Edition brings together, once again, a distinguished group of psychiatrists and clinical psychologists to take stock of which treatments and interventions actually work, which don't, and what still remains beyond the scope of our current knowledge. The new edition has been extensively revised to take account of recent drug developments and advances in psychotherapeutic interventions. Incorporating a wealth of new information, these eminent researchers and clinicians thoroughly review all available outcome data and clinical trials and provide detailed specification of methods and procedures to ensure effective treatment for each major DSM-IV disorder. As an interdisciplinary work that integrates information from both clinical psychology and psychiatry, this new edition will continue to serve as an essential volume for practitioners of every kind: psychiatrists, psychologists, clinical social workers, counselors, and mental health consultants.

Selective Serotonin Reuptake Inhibitors (SSRIs)
Selective Serotonin Reuptake Inhibitors (SSRIs)

Author: S. Clare Stanford

Publisher: Landes Bioscience

Published: 1999

Total Pages: 248

ISBN-13:

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Details advantages and disadvantages of SSRIs. Starts with a personal memoir of the discovery of the first SSRI, then looks at SSRIs from the clinical point of view. Later chapters concentrate on preclinical material. A final chapter makes pharmacological and clinical comparisons between the tricycl

NeuroPsychopharmacotherapy
NeuroPsychopharmacotherapy

Author: Peter Riederer

Publisher: Springer Nature

Published: 2022-11-04

Total Pages: 4652

ISBN-13: 303062059X

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This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.

Pharmacotherapy for Depression and Treatment-resistant Depression
Pharmacotherapy for Depression and Treatment-resistant Depression

Author: George I. Papakostas

Publisher: World Scientific

Published: 2010

Total Pages: 726

ISBN-13: 9814287598

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1. Major depressive disorder and treatment-resistant depression. 1.1. Major depressive disorder. 1.2. Treatment-resistant depression (TRD). 1.3. Demographic and clinical risk factors for resistant depression -- 2. Monoaminergic-based strategies : "Single-acting" agents. 2.1. Monoamine precursors for depression. 2.2. Selective serotonin reuptake inhibitors (SSRIs). 2.3. Serotonin receptor antagonists and agonists. 2.4. Serotonin reuptake enhancers. 2.5. [symbol]-2 adrenergic receptor agonists and antagonists. 2.6. Norepinephrine reuptake inhibitors (NRIs). 2.7. Selective [symbol] adrenergic receptor agonists. 2.8. Dopamine-selective agents -- 3. Monoaminergic-based strategies : "Dual-acting" agents. 3.1. Tricyclic antidepressants (TCAs). 3.2. Serotonin-norepinephrine reuptake inhibitors (SNRIs). 3.3. 5HT-2 and [symbol]-2 adrenergic receptor antagonists. 3.4. Norepinephrine-dopamine reuptake inhibitors -- 4. Monoaminergic-based strategies : "Triple-acting " agents. 4.1. Monoamine oxidase inhibitors (MAOIs). 4.2. Serotonin-norepinephrine-dopamine reuptake inhibitors. 4.3. Catechol-O-methyltransferase (COMT) inhibitors -- 5. Polypharmacy from the onset of treatment. 5.1. Adjunctive treatment with monoaminergic agents. 5.2. Adjunctive treatment with neuroendocrine agents. 5.3. Other agents -- 6. Polypharmacy strategies for treatment-resistant depression. 6.1. Adjunctive treatment with monoaminergic agents. 6.2. Adjunctive treatment with neuroendocrine agents. 6.3. Other agents -- 7. Monotherapy strategies for resistant depression. 7.1. Increasing the dose of antidepressants. 7.2. Switching antidepressants due to lack of efficacy -- 8. Non-pharmacologic approaches for resistant depression. 8.1. Device-based therapies. 8.2. Psychotherapy. 8.3. Exercise. 8.4. Yoga and meditation -- 9. Pharmacotherapy of relapse/recurrence prevention and treatment. 9.1. Antidepressant continuation and maintenance therapy studies. 9.2. Special topics in the pharmacotherapy of relapse prevention. 9.3. Treatment of depressive relapse/recurrence -- 10. Pharmacologic strategies to enhance antidepressant tolerability. 10.1. Adjunctive therapy. 10.2. Switching antidepressants due to intolerance -- 11. Agents operating on non-monoaminergic neurotransmitter systems. 11.1. GABA-ergic treatments. 11.2. Glycine and glutamate-based treatments. 11.3. Agents with combined GABA-ergic and glutamatergic activity. 11.4. Other anticonvulsants. 11.5. Neurokinin-receptor antagonists. 11.6. Nicotinic receptor-based treatments. 11.7. Cannabinoids and endocannabinoids. 11.8. Opioidergic therapies. 11.9. Other neurotransmitter systems -- 12. Neuroendocrine-based agents. 12.1. Hypothalamic-pituitary-gonadal axis (HPG). 12.2. Hypothalamic-pituitary-adrenal axis (HPA). 12.3. Hypothalamic-pituitary-thyroid axis (HPT). 12.4. Melatonin and melatonergic agents. 12.5. Other hormones -- 13. Metabolic-based and other agents. 13.1. Metabolic-based agents. 13.2. Agents with unknown mechanism of action -- 14. Biological predictors, moderators, and mediators of efficacy. 14.1. Definition and significance of mediators of outcome. 14.2. Genetic markers. 14.3. Neurophysiology. 14.4. Molecular biology