Molecular Biology of RGS Proteins, a volume of Progress in Molecular Biology and Translational Science, will include historical discussion of RGS proteins, the role of RGS proteins in addiction, depression and Parkinson's disease and the biology and functional regulation of RGS9 isoforms. This publication further discusses RGS proteins in cellular signaling, protein control in lymphocyte function, and alternative splicing of RGS transcripts and nuclear RGS proteins, offering the latest in research of RGS proteins.
RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. - Brings together information on the current state of the RGS protein field - Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking - Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery
"This is such a great book for primary school age children and a little beyond for finding out about the world, its countries and people" Amazon customer review - Philip's atlas, designed specially to use at home and at school with guidance for parents and teachers - Clear maps and fascinating facts bring geography to life for readers aged 7-12 - Published in association with the Royal Geographical Society - Quizzes, activity ideas and puzzles to make learning fun - Past winner of the Geographical Association's award for making a significant contribution to geography The atlas is organized spread by spread in the classic sequence: first Europe, then its land neighbour Asia, followed by Africa, Australia and Oceania, North America and South America. Illustrated with captivating full-colour photographs and packed with fact boxes, curiosities, flags, stamps and quiz questions, Philip's RGS Children's Atlas is both fun to use and easy to understand. Now in its 16th edition, Philip's RGS Children's Atlas is a past winner of the Geographical Association's award for making a significant contribution to geography. The atlas was judged "an excellent 'all round' children's atlas with simple yet well-designed maps, well-illustrated with colour photographs. It links places to issues, events and real people, giving a clear sense of place."
Written for 5 to 7 year-old this atlas is ideal for teaching Key Stage 1, helping to cover geography, history, science, citizenship and literacy requirements - Written by experts Professor David Wright and Rachel Noonan - Published in association with the Royal Geographical Society - 50 pages of clear, child-friendly maps showing our world today - Countries of the world brought to life with flags, illustrations and photos - Bold text, simple words and short sentences to encourage reading skills - Starts with the Earth as a Planet then zooms into each of the world's regions with maps and illustrations - Numbered balloons on each map link to photos of a real place Fully revised and updated, the atlas is for children aged 5-7 in the early stages of reading, with simple text to explain what is happening on the maps and illustrations - all compatible with National Curriculum Key Stage 1. Clear, child-friendly maps are combined with vibrant photographs and facts about the world to provide essential geographical information for young children. Guidance is given at the beginning of the atlas on how to use the maps, encouraging the early development of map skills and knowledge of the world. Each colourful spread is illustrated with photographs and packed with fact boxes, curiosities, flags, stamps and simple quiz questions. Philip's RGS Infant School Atlas is both fun to use and easy to understand. The text is simple and uncomplicated to encourage early reading skills.
On the Boston Common stands one of the great Civil War memorials, a magnificent bronze sculpture by Augustus Saint-Gaudens. It depicts the black soldiers of the Fifty-fourth Massachusetts Infantry marching alongside their young white commander, Colonel Robert Gould Shaw. When the philosopher William James dedicated the memorial in May 1897, he stirred the assembled crowd with these words: "There they march, warm-blooded champions of a better day for man. There on horseback among them, in the very habit as he lived, sits the blue-eyed child of fortune." In this book Shaw speaks for himself with equal eloquence through nearly two hundred letters he wrote to his family and friends during the Civil War. The portrait that emerges is of a man more divided and complex--though no less heroic--than the Shaw depicted in the celebrated film Glory. The pampered son of wealthy Boston abolitionists, Shaw was no abolitionist himself, but he was among the first patriots to respond to Lincoln's call for troops after the attack on Fort Sumter. After Cedar Mountain and Antietam, Shaw knew the carnage of war firsthand. Describing nightfall on the Antietam battlefield, he wrote, "the crickets chirped, and the frogs croaked, just as if nothing unusual had happened all day long, and presently the stars came out bright, and we lay down among the dead, and slept soundly until daylight. There were twenty dead bodies within a rod of me." When Federal war aims shifted from an emphasis on restoring the Union to the higher goal of emancipation for four million slaves, Shaw's mother pressured her son into accepting the command of the North's vanguard black regiment, the Fifty-fourth Massachusetts. A paternalist who never fully reconciled his own prejudices about black inferiority, Shaw assumed the command with great reluctance. Yet, as he trained his recruits in Readville, Massachusetts, during the early months of 1963, he came to respect their pluck and dedication. "There is not the least doubt," he wrote his mother, "that we shall leave the state, with as good a regiment, as any that has marched." Despite such expressions of confidence, Shaw in fact continued to worry about how well his troops would perform under fire. The ultimate test came in South Carolina in July 1863, when the Fifty-fourth led a brave but ill-fated charge on Fort Wagner, at the approach to Charleston Harbor. As Shaw waved his sword and urged his men forward, an enemy bullet felled him on the fort's parapet. A few hours later the Confederates dumped his body into a mass grave with the bodies of twenty of his men. Although the assault was a failure from a military standpoint, it proved the proposition to which Shaw had reluctantly dedicated himself when he took command of the Fifty-fourth: that black soldiers could indeed be fighting men. By year's end, sixty new black regiments were being organized. A previous selection of Shaw's correspondence was privately published by his family in 1864. For this volume, Russell Duncan has restored many passages omitted from the earlier edition and has provided detailed explanatory notes to the letters. In addition he has written a lengthy biographical essay that places the young colonel and his regiment in historical context.
