Retinoblastoma is a rare type of cancer of the eye, often developing in early childhood, that affects the retina, the light sensitive tissue at the back of the eye that detects light and colour. This book is a step by step guide to all aspects of retinoblastoma. Beginning with sections on epidemiology, pathogenesis, genetics, clinical features, staging and diagnosis, the text then discusses different treatment therapies – chemotherapy and radiation. The final section explores supportive care including visual rehabilitation and psycho-social aspects, and future trends. With contributions from nearly 70 experts throughout the USA, Europe and Asia, this book contains 350 illustrative images and photographs. An appendix including chemotherapy regimens with appropriate dosage for children has been provided for quick reference.
Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypothesis of oncogenesis tinue to face delays in diagnosis, poor access to care, proposed by Alfred Knudson provided the conceptual and suboptimal treatment – the problem in the less framework for tumor suppressor gene research and developed world is cure. led to the discovery of the retinoblastoma pathway as In this book, we have invited a team of experts to a key element in cancer development. More recently, address all those important aspects of retinoblastoma the treatment of children with retinoblastoma has also research and therapy - from biology to epidemiology provided a model for modern approach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.
Provides the practising ophthalmologist and the resident in training with a comprehensive reference source for the various tumours and pseudotumours that can affect the intraocular structures. Over 1000 illustrations help the reader organize and perform therapeutic procedures.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Retinoblastoma constitutes a global disease that burdens many families all over the world. This book highlights the essential basic information needed by every ophthalmologist and covers all aspects of this tumor: history, genetics, epidemiology, clinical features, diagnosis, imaging, management, and prognosis. The book includes basic knowledge, but is also designed to discuss current treatment modalities showing improved survival compared to the past. A whole chapter is dedicated to histopathological features and the American Joint Commission on Cancer staging system, with the aim of having it internationally used in all countries to improve outcomes and for research purposes. Readers will find the book enjoyable, comprehensive, and easy to understand.
Thoroughly revised and updated, the 2nd Edition presents all of the latest advances in the field, including the most recent technologies and techniques. For each tumor site discussed, readers will find unparalleled coverage of multiple treatment plans, histology and biology of the tumor, its anatomic location and routes of spread, and utilization of specialized techniques. This convenient source also reviews all of the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Comprehensively reviews each topic, with a distinct clinical orientation throughout. Serves as a foundation for the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Guides readers through all stages of treatment application with step-by-step techniques for the assessment and implementation of radiotherapeutic options. Presents latest information on brachytherapy * 3-dimensional conformal treatment planning * sterotactic radiosurgery * and radiolabeled antibodies. Discusses the recent use of radiotherapy in the treatment of primary lymphoma, leukemia, multiple myeloma, and cancers of the prostate and central nervous system. Includes the latest AJCC staging system guidelines. Offers the latest advances in techniques, allowing you to deliver doses precisely to areas affected by malignancy and spare healthy tissue. Presents new chapters on the hottest topics including Three Dimensional Conformal Radiotherapy * Intensity Modulated Radiotherapy * Breathing Synchronized Radiotherapy * Plasma Cell Tumors: Multiple Myeloma and Solitary Plasmacytoma * Extracranial Stereotactic Radioablation * and [Imaging of the] Head and Neck * Thorax * Abdomen * and Pelvis.
This book is intended to provide a quick guide to the field of pediatric retina. It has been long accepted that retinal disorders in children differ from those in adults. Although there are plenty of published books on retinal diseases, most of them only cover adult retinal disorders. Therefore, information on pediatric retinal diseases is urgently needed. The book combines comprehensive information with rich illustrations to offer readers an in-depth understanding of the two main themes: retinopathy of prematurity (ROP) and other pediatric vitreoretinal disorders. World-renowned pediatric retina experts share their insights and research findings in areas such as ROP, familiar exudative vitreoretinopathy, Coats disease, retinoblastoma, congenital x-linked retinoschisis and hereditary retinal diseases. Topics concerning modern and future medicine such as tele-screening for ROP, E-learning for ROP, and deep learning for ROP are also included. Designed to help readers understand the contents as quickly as possible, the book includes many useful tips and pearls, as well as easy-to-follow figures. It covers the majority of pediatric retinal diseases and offers essential information on their diagnosis and management. In addition, relevant and up-to-date references are provided for those who want to explore the topics in more depth. As such, the book offers an excellent reference guide to caring for these young patients.
Intraocular inflammation is particularly difficult to diagnose and treat, often resembling a complex puzzle of patient history, symptoms, imaging, and laboratory test results. Clinical Cases in Uveitis: Differential Diagnosis and Management is a unique, case-based resource designed to help you navigate the range of challenging manifestations and presentations that often mimic other diseases. More than 90 real-world uveitis cases are presented in a highly templated, easy-to-follow format, along with step-by-step guidance on the right patient questions, assessment, differential diagnosis, testing, management, and follow-up care. - Provides a variety of patient presentations and scenarios and unique clinical situations that mirror day-to-day practice. - Covers current diagnostic imaging modalities, including optical coherence tomography (OCT), optical coherence tomography angiography, fluorescein angiography (FA), and indocyanine green angiography (ICG). - Features diagnostic and management algorithms that assist in differential diagnosis and decision making for even the most complex cases, including those in which the patient does not improve as expected, prompting a reassessment of diagnosis and management. - Contains approximately 250 high-quality images, including color anterior segment photographs, color fundus photographs, OCT images, and angiograms. - Discusses distinguishing infectious from non-infectious inflammation; when and how to start systemic immunosuppressive therapy; diagnostic criteria and management of "white dot syndromes; pediatric uveitis; masquerade syndromes, including inherited retinal degenerations, malignancies, and paraneoplastic syndromes; and much more. - Includes the authors' specific thought processes and approach in particularly challenging cases. - An excellent resource and study tool for ophthalmology residents and fellows, those studying for oral boards, general ophthalmologists, retina specialists, and more.
