Recent Advances in Cannabinoid Physiology and Pathology
Recent Advances in Cannabinoid Physiology and Pathology

Author: Anna N. Bukiya

Publisher: Springer

Published: 2019-07-22

Total Pages: 171

ISBN-13: 303021737X

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The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems.

Marijuana and Medicine
Marijuana and Medicine

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1999-07-10

Total Pages: 288

ISBN-13: 0309071550

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The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€"the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.

Recent Advances in Cannabinoid Physiology and Pathology
Recent Advances in Cannabinoid Physiology and Pathology

Author: Anna N. Bukiya

Publisher:

Published: 2019

Total Pages:

ISBN-13: 9783030217389

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This book comprehensively covers modern topics in cannabinoid research and medicinal use. The chapters span topics from the role of endocannabinoid system in embryonic and fetal development to cardiovascular disease, cancer, drug abuse and cutting-edge therapeutic applications. The content is presented at different levels of resolution. First, following an introduction into cannabinoid system components, readers are immersed into cannabinoid chemistry with a systematic overview of structural data that describe cannabinoid complexes with proteins at the atomic resolution. The remaining chapters capitalize on these interactions. They describe the cannabinoid role during embryonic, fetal, and adolescent development, in the cardiovascular system, cancer progression, and development of alcohol use disorders. Next, the topic of illicit marijuana use and abuse is discussed with an emphasis on possible genetic factors that may play a role in dependence. The book concludes with the most integrative level. It covers promising pharmacological leads in medicinal use of cannabimimetics to treat pain, epilepsy, and neurodegenerative disorders. The book brings together contributions from researchers and clinical scientists at different career stages. While some chapters are presented by well-recognized names, others are written by young investigators emerging in the field of cannabinoid research and medicinal use. The book will be of interest to audiences from biological/chemical disciplines with keen interest in the physiological effects of cannabis. The text quickly introduces the reader to the multi-faceted roles played by endogenous, phyto- and synthetic cannabinoids in health, disease, and modern drug development. Reader will gain insight into the current state of popular but still controversial topic of cannabinoids.

Recent Advances in the Science of Cannabis
Recent Advances in the Science of Cannabis

Author: Robert M. Strongin

Publisher: CRC Press

Published: 2021-11-18

Total Pages: 292

ISBN-13: 1000467716

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Recent Advances in the Science of Cannabis describes progress in a variety of significant areas of cannabis science. This unique book covers topics in cultivation and secondary metabolites, aroma and chemotypes, cannabinoid structures, physiology and pharmacology, as well as the development of unique topical products. State-of-the-art analytical methods and instrumentation are covered, including current developments in mass spectrometry and chromatography, as well as microbial testing. Given the popularity of smoking and vaporizing cannabis, the chemistry of vaping cannabinoid and terpene concentrates is also presented, along with emerging regulatory issues. Key Features: A guide to emerging modern cannabis technology in a dynamic regulatory climate and appealing to both novices and specialists. Building upon pioneering studies of terpene and cannabinoid chemistry, this distinctive volume describes current best practices, technological breakthroughs and historical context. Written by researchers in industry and academia, a greater understanding of the risks of exposure to emissions from vaping or dabbing cannabis concentrates is provided here. A selection of the book content reviewing Thermal Degradation of Cannabinoids and Cannabis Terpenes has been included in “Hot 2021” RSC Advances.

The Endocannabinoid System
The Endocannabinoid System

Author: Eric Murillo-Rodriguez

Publisher: Academic Press

Published: 2017-05-12

Total Pages: 258

ISBN-13: 0128096675

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The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. - Provides an introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain - Presents information on neurobiological and cellular studies on the role of the cannabinoid signaling system and its implications in human diseases - Includes well-written overviews of the basics of endocannabinoid system structure and function - Contains well-illustrated material, with diagrams, charts, and tables - Explores compelling case studies and their application to chapters written by experts

Handbook of Cannabis for Clinicians: Principles and Practice
Handbook of Cannabis for Clinicians: Principles and Practice

Author: Dustin Sulak DO

Publisher: W. W. Norton & Company

Published: 2021-06-29

Total Pages: 438

ISBN-13: 0393714195

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The first foundational text on the clinical use of cannabis and cannabinoid therapies. Despite thousands of years of medical use and an impressive record of safety, versatility, and efficacy, Cannabis sativa has existed outside the modern pharmacopeia since the 1940s. Primarily driven by popular demand, this botanical has returned to health care, but most clinicians lack the knowledge essential for identifying candidates for treatment, guiding patients, maximizing benefit, and minimizing harm. Dustin Sulak provides health care professionals—including physicians, psychologists, pharmacists, and nurses—with an accessible and evidence-based reference that empowers them to intelligently discuss cannabis with their patients and implement cannabis and cannabinoid therapies with confidence. Based on over a decade of clinical experience and an extensive review of the literature, this detailed and scientifically accurate guide includes the history of cannabis in medicine, the foundations of endocannabinoid physiology, the pharmacological effects of cannabis’ myriad active constituents, the clinical utility of its various preparations, and specific strategies and cautions for treating the most common conditions presenting to a cannabis clinician. This guide is an essential resource for practitioners of any specialty field or experience level who wish to improve their patients’ outcomes, harness the healing potential of the endocannabinoid system, and wield a powerful solution to many of healthcare’s challenges.

Discovery and Development of Anti-Breast Cancer Agents from Natural Products
Discovery and Development of Anti-Breast Cancer Agents from Natural Products

Author: Goutam Brahmachari

Publisher: Elsevier

Published: 2021-06-24

Total Pages: 386

ISBN-13: 0128212780

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Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. - Highlights active agents from natural sources for development as novel anti-cancer agents - Features contributions from active researchers and leading experts working in the field - Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

Cannabis and Cannabinoid-Based Medicines in Cancer Care
Cannabis and Cannabinoid-Based Medicines in Cancer Care

Author: Claude Cyr

Publisher: Springer Nature

Published: 2022-02-11

Total Pages: 325

ISBN-13: 3030899187

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The use of cannabinoid-based medicines (CBM), and cannabis in particular, has risen steadily among cancer and palliative care patients over the last few years. This textbook aims to address the multiple challenges facing healthcare providers regarding the use of CBM in this vulnerable patient population. It provides insight into the latest preclinical and clinical data and offers a practical approach on the use of CBM in a rapidly evolving landscape. It answers questions regarding the prescribing process and elucidates controversies regarding cannabis’ disease-modifying effects. The first chapters will review basic concepts of the endocannabinoid system and pharmacology of CBM, while focusing more specifically on the unique characteristics of two main cannabinoids: THC and CBD. Indicating which benefits can be expected from using either or both of these compounds, the book then addresses issues of drug-drug interactions and other challenges involved in prescribing CBM to frail patients with polypharmacy and multiple comorbidities. Comparing available products, both approved and non-approved by the FDA, the book discusses regional challenges for accessing reliably tested and labelled products in the context of standardization efforts. After carefully determining objectives and addressing patient expectations, further chapters will examine the different clinical settings in which CBM may be useful in cancer care and explore symptom management, including cancer pain, anxiety, nausea, and insomnia among others. The possible benefits of cannabis psychoactivity will also be discussed, including harm reduction strategies for patients who wish to explore these effects. Cannabis and Cannabinoid-Based Medicines in Cancer Care: A Comprehensive Guide to Medical Management serves as a comprehensive text for oncologists, palliative care specialists, general practitioners, and nurse practitioners working with cancer patients or in palliative care settings.

Behavioral Neurobiology of the Endocannabinoid System
Behavioral Neurobiology of the Endocannabinoid System

Author: Dave Kendall

Publisher: Springer Science & Business Media

Published: 2009-08-14

Total Pages: 418

ISBN-13: 3540889558

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The endocannabinoid signaling system is a key modulator of central nervous function. This volume, essential reading for interested neuroscientists, provides in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior.

Anandamide in Health and Disease
Anandamide in Health and Disease

Author: Bernard Le Foll

Publisher: Elsevier

Published: 2024-09-01

Total Pages: 568

ISBN-13: 0443302561

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Anandamide in Health and Disease, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, is a complete reference on the roles of anandamide in health and disease states. Following the characteristics of the series, this book provides a comprehensive overview of the effects of the mediator on human health.The book is divided into two parts, the first of which provides background information on biology, regulation, synthesis and degradation and modulation of anandamide. The second part is dedicated to covering the role of anandamide in various diseases. A comprehensive panel of authors cover several somatic and psychiatric disorders, such as anxiety disorders, mood disorders, psychosis and substance use disorders. Additionally, the role of anandamide across epilepsy, Alzheimer's disease, and digestive conditions is explored.Anandamide in Health and Disease is the perfect reference for bioscience researchers seeking to understand anandamide pharmacology, biochemistry, cellular, and molecular biology. Clinicians may also be interested in better understanding the wide-ranging health effects of the mediator. - Covers anandamide from a wide variety of specialties and systems. - Focuses on the cellular communication aspects of the mediator, and the wide range of effects on human health. - Emphasizes the integration of the various roles of anandamide mediated both centrally and peripherally.