Radicals for Life
Radicals for Life

Author: Ernst van Faassen

Publisher: Elsevier

Published: 2011-10-13

Total Pages: 444

ISBN-13: 0080489591

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Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes Extensive bibliographic references, written by specialists of human physiology Providing high scientific quality with a focus on implications for human diseases

Free Radicals in Biology and Medicine
Free Radicals in Biology and Medicine

Author: Barry Halliwell

Publisher: Oxford University Press

Published: 2015

Total Pages: 961

ISBN-13: 0198717474

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Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Radical Technologies
Radical Technologies

Author: Adam Greenfield

Publisher: Verso Books

Published: 2017-06-01

Total Pages: 396

ISBN-13: 1784780464

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A field manual to the technologies that are transforming our lives Everywhere we turn, a startling new device promises to transfigure our lives. But at what cost? In this urgent and revelatory excavation of our Information Age, leading technology thinker Adam Greenfield forces us to reconsider our relationship with the networked objects, services and spaces that define us. It is time to re-evaluate the Silicon Valley consensus determining the future. We already depend on the smartphone to navigate every aspect of our existence. We’re told that innovations—from augmented-reality interfaces and virtual assistants to autonomous delivery drones and self-driving cars—will make life easier, more convenient and more productive. 3D printing promises unprecedented control over the form and distribution of matter, while the blockchain stands to revolutionize everything from the recording and exchange of value to the way we organize the mundane realities of the day to day. And, all the while, fiendishly complex algorithms are operating quietly in the background, reshaping the economy, transforming the fundamental terms of our politics and even redefining what it means to be human. Having successfully colonized everyday life, these radical technologies are now conditioning the choices available to us in the years to come. How do they work? What challenges do they present to us, as individuals and societies? Who benefits from their adoption? In answering these questions, Greenfield’s timely guide clarifies the scale and nature of the crisis we now confront —and offers ways to reclaim our stake in the future.

Oxygen Radicals in Biology and Medicine
Oxygen Radicals in Biology and Medicine

Author: Michael Simic

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 1064

ISBN-13: 1468455680

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This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.

Rules for Radicals
Rules for Radicals

Author: Saul Alinsky

Publisher: Vintage

Published: 2010-06-30

Total Pages: 226

ISBN-13: 0307756890

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“This country's leading hell-raiser" (The Nation) shares his impassioned counsel to young radicals on how to effect constructive social change and know “the difference between being a realistic radical and being a rhetorical one.” First published in 1971 and written in the midst of radical political developments whose direction Alinsky was one of the first to question, this volume exhibits his style at its best. Like Thomas Paine before him, Alinsky was able to combine, both in his person and his writing, the intensity of political engagement with an absolute insistence on rational political discourse and adherence to the American democratic tradition.

Free Radicals
Free Radicals

Author: Michael Brooks

Publisher: ABRAMS

Published: 2012-04-26

Total Pages: 148

ISBN-13: 1468301713

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“An exuberant tour through the world of scientists behaving badly” (The New York Times). They may have a public image as cool, logical, levelheaded types. But in reality, scientists will do pretty much anything—take drugs, follow mystical visions, lie, and even cheat—to make a discovery. In Free Radicals, physicist and journalist Michael Brooks seamlessly weaves together true stories of the “mad, bad and dangerous” men and women who have revolutionized the scientific world, and offers a fast-paced and thrilling exploration of the real process behind discovery (The Times, London). Brooks also traces the cover-up back to its source: the scientific establishment’s reaction to the public fear of science after World War II. He argues that it its high time for science to come clean about just how bold and daring scientists really are. “Not all scientists are nerds. In Free Radicals, physicist Michael Brooks tries to dispel the notion that scientists are stuffy, pen-protector-polishing bookworms.” —The Washington Post “Insightful . . . A page-turning, unvarnished look at the all-too-human side of science.” —Kirkus Reviews

Free Radicals in Human Health and Disease
Free Radicals in Human Health and Disease

Author: Vibha Rani

Publisher: Springer

Published: 2014-11-14

Total Pages: 427

ISBN-13: 8132220358

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The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

Systems Biology of Free Radicals and Antioxidants
Systems Biology of Free Radicals and Antioxidants

Author: Ismail Laher

Publisher: Springer

Published: 2014-06-16

Total Pages: 0

ISBN-13: 9783642300172

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The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

The Radicals
The Radicals

Author: Ryan McIlvain

Publisher: Hogarth

Published: 2018

Total Pages: 290

ISBN-13: 0553417886

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"When Eli first meets Sam Westergard, he is dazzled by his new friend's charisma, energy, and determined passion. Both graduate students in New York City, the two young men bond over their idealism, their love of poetry, and their commitment to socialism, both in theory and in practice--this last taking the form of an organized protest against Soline, a giant energy company that has speculated away the jobs and savings of thousands. As an Occupy-like group begins to coalesce around him, Eli realizes that some of his fellow intellectuals are more deeply--and dangerously--devoted to the cause than others"--Amazon.com.

Techniques in Free Radical Research
Techniques in Free Radical Research

Author: A.T. Diplock

Publisher: Elsevier

Published: 1991-12-11

Total Pages: 309

ISBN-13: 0080858910

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Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.