Protein Structure by Distance Analysis
Author: Henrik Bohr
Publisher: IOS Press
Published: 1994
Total Pages: 364
ISBN-13: 9784274022630
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Molecular Biology of the Cell
Author:
Publisher:
Published: 2002
Total Pages: 0
ISBN-13: 9780815332183
DOWNLOAD EBOOKConstrained Optimization and Lagrange Multiplier Methods
Author: Dimitri P. Bertsekas
Publisher: Academic Press
Published: 2014-05-10
Total Pages: 412
ISBN-13: 148326047X
DOWNLOAD EBOOKComputer Science and Applied Mathematics: Constrained Optimization and Lagrange Multiplier Methods focuses on the advancements in the applications of the Lagrange multiplier methods for constrained minimization. The publication first offers information on the method of multipliers for equality constrained problems and the method of multipliers for inequality constrained and nondifferentiable optimization problems. Discussions focus on approximation procedures for nondifferentiable and ill-conditioned optimization problems; asymptotically exact minimization in the methods of multipliers; duality framework for the method of multipliers; and the quadratic penalty function method. The text then examines exact penalty methods, including nondifferentiable exact penalty functions; linearization algorithms based on nondifferentiable exact penalty functions; differentiable exact penalty functions; and local and global convergence of Lagrangian methods. The book ponders on the nonquadratic penalty functions of convex programming. Topics include large scale separable integer programming problems and the exponential method of multipliers; classes of penalty functions and corresponding methods of multipliers; and convergence analysis of multiplier methods. The text is a valuable reference for mathematicians and researchers interested in the Lagrange multiplier methods.
Statistics for Research
Author: Shirley Dowdy
Publisher: John Wiley & Sons
Published: 2011-09-26
Total Pages: 646
ISBN-13: 0471477427
DOWNLOAD EBOOKPraise for the Second Edition "Statistics for Research has other fine qualities besides superior organization. The examples and the statistical methods are laid out with unusual clarity by the simple device of using special formats for each. The book was written with great care and is extremely user-friendly."—The UMAP Journal Although the goals and procedures of statistical research have changed little since the Second Edition of Statistics for Research was published, the almost universal availability of personal computers and statistical computing application packages have made it possible for today's statisticians to do more in less time than ever before. The Third Edition of this bestselling text reflects how the changes in the computing environment have transformed the way statistical analyses are performed today. Based on extensive input from university statistics departments throughout the country, the authors have made several important and timely revisions, including: Additional material on probability appears early in the text New sections on odds ratios, ratio and difference estimations, repeated measure analysis, and logistic regression New examples and exercises, many from the field of the health sciences Printouts of computer analyses on all complex procedures An accompanying Web site illustrating how to use SAS® and JMP® for all procedures The text features the most commonly used statistical techniques for the analysis of research data. As in the earlier editions, emphasis is placed on how to select the proper statistical procedure and how to interpret results. Whenever possible, to avoid using the computer as a "black box" that performs a mysterious process on the data, actual computational procedures are also given. A must for scientists who analyze data, professionals and researchers who need a self-teaching text, and graduate students in statistical methods, Statistics for Research, Third Edition brings the methodology up to date in a very practical and accessible way.
Textbook Of Structural Biology (Second Edition)
Author: Anders Liljas
Publisher: World Scientific
Published: 2016-09-27
Total Pages: 610
ISBN-13: 9813142499
DOWNLOAD EBOOKThis book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.
Protein Structure Prediction
Author: Mohammed Zaki
Publisher: Springer Science & Business Media
Published: 2007-09-12
Total Pages: 338
ISBN-13: 1588297527
DOWNLOAD EBOOKThis book covers elements of both the data-driven comparative modeling approach to structure prediction and also recent attempts to simulate folding using explicit or simplified models. Despite the unsolved mystery of how a protein folds, advances are being made in predicting the interactions of proteins with other molecules. Also rapidly advancing are the methods for solving the inverse folding problem, the problem of finding a sequence to fit a structure. This book focuses on the various computational methods for prediction, their successes and their limitations, from the perspective of their most well known practitioners.
Prediction of Protein Structure and the Principles of Protein Conformation
Author: G.D. Fasman
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 796
ISBN-13: 1461315719
DOWNLOAD EBOOKThe prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.
Computational Structural Biology
Author: Torsten Schwede
Publisher: World Scientific
Published: 2008
Total Pages: 790
ISBN-13: 9812778780
DOWNLOAD EBOOKThis is a comprehensive introduction to Landau-Lifshitz equations and Landau-Lifshitz-Maxwell equations, beginning with the work by Yulin Zhou and Boling Guo in the early 1980s and including most of the work done by this Chinese group led by Zhou and Guo since. The book focuses on aspects such as the existence of weak solutions in multi dimensions, existence and uniqueness of smooth solutions in one dimension, relations with harmonic map heat flows, partial regularity and long time behaviors. The book is a valuable reference book for those who are interested in partial differential equations, geometric analysis and mathematical physics. It may also be used as an advanced textbook by graduate students in these fields.
Protein Engineering and Design
Author: Paul R. Carey
Publisher: Elsevier
Published: 1996-06-21
Total Pages: 379
ISBN-13: 0080539971
DOWNLOAD EBOOKThe design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. - Introduces and defines the techniques involved in protein engineering and design - Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides
Measles Virus Nucleoprotein
Author: Sonia Longhi
Publisher: Nova Publishers
Published: 2007
Total Pages: 180
ISBN-13: 9781600216299
DOWNLOAD EBOOKMeasles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.
