Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Author: Venkataramana K Sidhaye

Publisher: Academic Press

Published: 2017-03-09

Total Pages: 277

ISBN-13: 0128038810

DOWNLOAD EBOOK

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. - Provides a single source of information on lung epithelial junctions and transporters - Discusses of the role of the epithelium in lung homeostasis and disease - Includes capsule summaries of main conclusions as well as highlights of future directions in the field - Covers the mechanistic basis for lung disease for a range of audiences

AMP-activated Protein Kinase
AMP-activated Protein Kinase

Author: Mario D. Cordero

Publisher: Springer

Published: 2016-11-02

Total Pages: 519

ISBN-13: 3319435892

DOWNLOAD EBOOK

AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.

Nuclear Trafficking
Nuclear Trafficking

Author: Carl Feldherr

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 385

ISBN-13: 0323152988

DOWNLOAD EBOOK

Nuclear Trafficking is a summary of the state of knowledge in nuclear trafficking, and is organized into five parts. The book begins by discussing the diffusion and signal-mediated transport through the pores. It then looks into the detailed accounts of pore structure and composition, nuclear localization signals, signal binding proteins, RNA efflux, and biochemical factors influencing nucleocytoplasmic exchange. This book will be very useful to those people new to this field of interest.

Kinomics
Kinomics

Author: Heinz-Bernhard Kraatz

Publisher: John Wiley & Sons

Published: 2015-11-16

Total Pages: 364

ISBN-13: 3527337652

DOWNLOAD EBOOK

Das umfassende Referenzwerk zur Kinase-Forschung: Ausführlich werden die Themen Kinase-Engineering, Peptidsubstrat-Engineering, das Design von Co-Substraten und Kinasehemmer erläutert sowie deren Anwendung in der Bio- und Pharmaforschung beschrieben.

Protein Kinases and Stress Signaling in Plants
Protein Kinases and Stress Signaling in Plants

Author: Girdhar K. Pandey

Publisher: John Wiley & Sons

Published: 2020-12-03

Total Pages: 560

ISBN-13: 1119541565

DOWNLOAD EBOOK

A comprehensive review of stress signaling in plants using genomics and functional genomic approaches Improving agricultural production and meeting the needs of a rapidly growing global population requires crop systems capable of overcoming environmental stresses. Understanding the role of different signaling components in plant stress regulation is vital to developing crops which can withstand abiotic and biotic stresses without loss of crop yield and productivity. Emphasizing genomics and functional genomic approaches, Protein Kinases and Stress Signaling in Plants is a comprehensive review of cutting-edge research on stress perception, signal transduction, and stress response generation. Detailed chapters cover a broad range of topics central to improving agricultural production developing crop systems capable of overcoming environmental stresses to meet the needs of a rapidly growing global population. This book describes the field of protein kinases and stress signaling with a special emphasis on functional genomics. It presents a highly valuable contribution in the field of stress perception, signal transduction and generation of responses against one or multiple stress signals. This timely resource: Summarizes the role of various kinases involved in stress management Enumerates the role of TOR, GSK3-like kinase, SnRK kinases in different physiological conditions Examines mitogen-activated protein kinases (MAPKs) in different stresses Describes the different aspects of calcium signaling under different stress conditions Examines photo-activated kinases (PAPKs) in varying light conditions Briefs the presence of tyrosine kinases in plants Highlights the cellular functions of receptor ]like protein kinases (RLKs) Possible implication of these kinases in developing stress tolerant crops Protein Kinases and Stress Signaling in Plants: Functional Genomic Perspective is an essential resource for researchers and students in the fields of plant molecular biology and signal transduction, plant responses to stress, plant cell signaling, plant protein kinases, plant biotechnology, transgenic plants and stress biology.

Next Generation Kinase Inhibitors
Next Generation Kinase Inhibitors

Author: Paul Shapiro

Publisher: Springer Nature

Published: 2020-07-14

Total Pages: 224

ISBN-13: 3030482839

DOWNLOAD EBOOK

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Author:

Publisher: Academic Press

Published: 2018-11-21

Total Pages: 294

ISBN-13: 0128127384

DOWNLOAD EBOOK

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. - Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research - Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms - Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment