Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.
This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
In the past decade, few subjects at the intersection of medicine and sports have generated as much public interest as sports-related concussions - especially among youth. Despite growing awareness of sports-related concussions and campaigns to educate athletes, coaches, physicians, and parents of young athletes about concussion recognition and management, confusion and controversy persist in many areas. Currently, diagnosis is based primarily on the symptoms reported by the individual rather than on objective diagnostic markers, and there is little empirical evidence for the optimal degree and duration of physical rest needed to promote recovery or the best timing and approach for returning to full physical activity. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture reviews the science of sports-related concussions in youth from elementary school through young adulthood, as well as in military personnel and their dependents. This report recommends actions that can be taken by a range of audiences - including research funding agencies, legislatures, state and school superintendents and athletic directors, military organizations, and equipment manufacturers, as well as youth who participate in sports and their parents - to improve what is known about concussions and to reduce their occurrence. Sports-Related Concussions in Youth finds that while some studies provide useful information, much remains unknown about the extent of concussions in youth; how to diagnose, manage, and prevent concussions; and the short- and long-term consequences of concussions as well as repetitive head impacts that do not result in concussion symptoms. The culture of sports negatively influences athletes' self-reporting of concussion symptoms and their adherence to return-to-play guidance. Athletes, their teammates, and, in some cases, coaches and parents may not fully appreciate the health threats posed by concussions. Similarly, military recruits are immersed in a culture that includes devotion to duty and service before self, and the critical nature of concussions may often go unheeded. According to Sports-Related Concussions in Youth, if the youth sports community can adopt the belief that concussions are serious injuries and emphasize care for players with concussions until they are fully recovered, then the culture in which these athletes perform and compete will become much safer. Improving understanding of the extent, causes, effects, and prevention of sports-related concussions is vitally important for the health and well-being of youth athletes. The findings and recommendations in this report set a direction for research to reach this goal.
This book is a collection of research articles presented at the 4th International Conference on Communications and Cyber-Physical Engineering (ICCCE 2021), held on April 9 and 10, 2021, at CMR Engineering College, Hyderabad, India. ICCCE is one of the most prestigious conferences conceptualized in the field of networking and communication technology offering in-depth information on the latest developments in voice, data, image, and multimedia. Discussing the latest developments in voice and data communication engineering, cyber-physical systems, network science, communication software, image, and multimedia processing research and applications, as well as communication technologies and other related technologies, it includes contributions from both academia and industry. This book is a valuable resource for scientists, research scholars, and PG students working to formulate their research ideas and find the future directions in these areas. Further, it may serve as a reference work to understand the latest engineering and technologies used by practicing engineers in the field of communication engineering.
A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.
This is an open access book.Molecular biology has given a great impact in life science investigation. The advances in molecular biology over the last several decades have boosted research and product development in many disciplines of life science, including Biotechnology and Pharmacy. This advances comprise: (1) the progression of more sophisticated techniques in molecular biology with a broad, interdisciplinary applications; (2) the expanding flow of information of technical novelties and scientific discoveries across scientific community; and (3) the development of more sophisticated software and continuously updated databases. This has changed the rationale and approach of experimentations giving rise to revolutionizing discoveries in many fields od science. It has become evident that the deregulation of molecular processes in body is associated with, and in certain circumstances is the direct cause of, a wide range of pathological conditions. It is necessary to mention the biomedical relevance of molecular biology-related investigations for drug discovery and the development of a more personalized medicine. Given the rapidly changing and continuously evolving nature of the molecular biology field, we can anticipate that the revolutionary impact of molecular biology in life sciences is only at the beginning and is far from being finished. To highlight the rapidly growing research and product development in the field of Biotechnology and Pharmacy, the 4th International Conference on Natural Resources and Life Sciences (NRLS)” themed Biotechnology- and pharmacy-driven research and product development is presented. Following the successful program of 1st, 2nd, and 3rd NRLS, we intend to hold the next two-day conference along with a one-day optional workshop in 4th NRLS, as a scientific forum for biotechnology and pharmacy researchers and product developers to discuss the recent advances in the fields and their application. It is a great pleasure to invite you to the forthcoming 4th NRLS Conference, which will be held virtually, on August 24th-25th 2022, and the following onsite workshop on August 26th, 2022.
In today’s world, the use of technology is growing rapidly, and people need effective solutions for their real-life problems. This book discusses smart applications of associated technologies to develop cohesive and comprehensive solutions for the betterment of humankind. It comprehensively covers the effective use of the Internet of Things (IoT), wireless sensor network, wearable sensors, body area network, cloud computing, and distributed computing methodologies. The book comprehensively covers IoT and fog computing sensor supported technologies or protocols including web of things, near-field communication, 6LoWPAN, LoRAWAN, XMPP, DDS, LwM2M, Mesh Protocol, and radio-frequency identification. The book- Discusses smart applications to develop cohesive and comprehensive solutions for real-life problems. Covers analytical descriptions with appropriate simulation and prototype models. Examines the role of IoT and fog computing technologies during global emergency situations. Discusses key technologies including cloud computing, 5G communication, big data, artificial intelligence, control systems, and wearable sensors. The text is primarily written for graduate students, and academic researchers working in diverse fields of electrical engineering, biomedical engineering, electronics and communication engineering, computer engineering, and information technology.
Health Care Paradigms in the Internet of Things Ecosystem brings all IoT-enabled health care related technologies into a single platform so that undergraduate and postgraduate students, researchers, academicians and industry leaders can easily understand IoT-based healthcare systems. The book uses data and network engineering and intelligent decision support system-by-design principles to design a reliable IoT-enabled health care ecosystem and to implement cyber-physical pervasive infrastructure solutions. It takes the reader on a journey that begins with understanding the healthcare monitoring paradigm in IoT-enabled technologies and how it can be applied in various aspects. In addition, the book walks readers through real-time challenges and presents a guide on how to build a safe infrastructure for IoT-based health care. It also helps researchers and practitioners understand the e-health care architecture through IoT and the state-of-the-art in IoT countermeasures. Readers will find this to be a comprehensive discussion on functional frameworks for IoT-based healthcare systems, intelligent medicine, RFID technology, HMI, Cognitive Interpretation, Brain-Computer Interface, Remote Health Monitoring systems, wearable sensors, WBAN, and security and privacy issues in IoT-based health care monitoring systems. - Presents the complete functional framework workflow in IoT-enabled healthcare technologies - Explains concepts of location-aware protocols and decisive mobility in IoT healthcare - Provides complete coverage of intelligent data processing and wearable sensor technologies in IoT-enabled healthcare - Explores the Human Machine Interface and its implications in patient-care systems in IoT healthcare - Explores security and privacy issues and challenges related to data-intensive technologies in healthcare-based Internet of Things
This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies. Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds. Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.
