Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimization have proven successful in many recent research programs. These methods have grown in their effectiveness not only because of improved understanding of the basic science - the biological events and molecular interactions that define a target for therapeutic intervention - but also because of advances in algorithms, representations, and mathematical procedures for studying such processes. This volume surveys some of those advances. A broad landscape of high-profile topics in computer-assisted molecular design (CAMD) directed to drug design are included. Subject areas represented in the volume include receptor-based applications such as binding energy approximations, molecular docking, and de novo design; non-receptor-based applications such as molecular similarity; molecular dynamics simulations; solvation and partitioning of a solute between aqueous and nonpolar media; graph theory; non-linear multidimensional optimization, processing of information obtained from simulation studies, global optimization and search strategies, and performance enhancement through parallel computing.
This introduction to Atomic and Molecular Physics explains how our present model of atoms and molecules has been developed over the last two centuries both by many experimental discoveries and, from the theoretical side, by the introduction of quantum physics to the adequate description of micro-particles. It illustrates the wave model of particles by many examples and shows the limits of classical description. The interaction of electromagnetic radiation with atoms and molecules and its potential for spectroscopy is outlined in more detail and in particular lasers as modern spectroscopic tools are discussed more thoroughly. Many examples and problems with solutions are offered to encourage readers to actively engage in applying and adapting the fundamental physics presented in this textbook to specific situations. Completely revised third edition with new sections covering all actual developments, like photonics, ultrashort lasers, ultraprecise frequency combs, free electron lasers, cooling and trapping of atoms, quantum optics and quantum information.
The Standard Model of particle physics is an amazingly successful theory describing the fundamental particles and forces of nature. This text, written for a two-semester graduate course on the Standard Model, develops a practical understanding of the theoretical concepts it's built upon, to prepare students to enter research. The author takes a historical approach to demonstrate to students the process of discovery which is often overlooked in other textbooks, presenting quantum field theory and symmetries as the necessary tools for describing and understanding the Standard Model. He develops these tools using a basic understanding of quantum mechanics and classical field theory, such as Maxwell's electrodynamics, before discussing the important role that Noether's theorem and conserved charges play in the theory. Worked examples feature throughout the text, while homework exercises are included for the first five parts, with solutions available online for instructors. Inspired by the author's own teaching experience, suggestions for independent research topics have been provided for the second-half of the course, which students can then present to the rest of the class.
This book reviews the important achievements in subatomic physics in the past century. The chapters are divided into two parts: nuclear physics and particle physics. This book provides academics and researchers an essential overview of the present state of knowledge in nuclear and particle physics.
Quick Calculus 2nd Edition A Self-Teaching Guide Calculus is essential for understanding subjects ranging from physics and chemistry to economics and ecology. Nevertheless, countless students and others who need quantitative skills limit their futures by avoiding this subject like the plague. Maybe that's why the first edition of this self-teaching guide sold over 250,000 copies. Quick Calculus, Second Edition continues to teach the elementary techniques of differential and integral calculus quickly and painlessly. Your "calculus anxiety" will rapidly disappear as you work at your own pace on a series of carefully selected work problems. Each correct answer to a work problem leads to new material, while an incorrect response is followed by additional explanations and reviews. This updated edition incorporates the use of calculators and features more applications and examples. ".makes it possible for a person to delve into the mystery of calculus without being mystified." --Physics Teacher
Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.
The aim of this book is to offer to the next generation of young researchers a broad and largely self-contained introduction to the physics of heavy ion collisions and the quark-gluon plasma, providing material beyond that normally found in the available textbooks. For each of the main aspects - QCD thermodynamics and global features of the QGP, collision hydrodynamics, electromagnetic probes, jet and quarkonium production, color glass condensate, and the gravity connection - the present volume provides extensive and pedagogical lectures, surveying the present status of both theory and experiment. A particular feature of this volume is that all lectures have been written with the active assistance of selected students present at the course in order to ensure the adequate level and coverage for the intended readership.