Photostability of Drugs and Drug Formulations, Second Edition
Photostability of Drugs and Drug Formulations, Second Edition

Author: Hanne Hjorth Tonnesen

Publisher: CRC Press

Published: 2004-06-29

Total Pages: 450

ISBN-13: 1420023594

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Providing the guidance needed for formulation, handling, and quality control of photolabile drugs, Photostability of Drugs and Drug Formulations, Second Edition explores the significance of new information on drug photoreactivity in a pharmaceutical context. Completely revised and updated, with chapter authors drawn from an international panel of experts, the book supplies the background necessary for planning standardized photochemical stability studies as a part of drug development and formulation work. It contains comprehensive coverage of the physical and chemical aspects of drug photoreactivity, formulation, stability testing, and drug design/discovery in one resource. The contents have been reorganized to focus on the standardization of photostability testing of drug substances and products, in vitro photoreactivity screening of drugs, and various aspects of the formulation of photoreactive substances. The information on in vitro screening of drug photoreactivity is of great relevance for scientists who are developing and validating a set of testing protocols to address photosafety. Discussing kinetic and chemical aspects of drug photodecomposition as well as the practical problems frequently encountered in photochemical stability testing, this book helps you design a test protocol and interpret the results. Features Assists non-experts in this field design a test protocol and interpret the results Covers in vitro and in vivo aspects of interactions between drugs and light Explores the kinetic and chemical aspects of drug photodecomposition Discusses the problems frequently encountered in photochemical stability testing Provides guidance on how to address photosafety assessments and labeling requirements of potentially photoreactive drugs Highlights the practical implications of drug photodecomposition from a pharmaceutical viewpoint Offers specific guidance in photostability testing and screening of drug photoreactivity

Photostability Of Drugs And Drug Formulations
Photostability Of Drugs And Drug Formulations

Author: Hanne Hjorth Tonnesen

Publisher: CRC Press

Published: 1996-09-03

Total Pages: 416

ISBN-13: 074840449X

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This text discusses various aspects of the combination of drugs and light. Degradation processes, stabilization of photolabile drug substances within formulations, benefits from the combination of drugs and light, and testing of drug photoreactivity, are some of the topics discussed.

Pharmaceutical Crystals
Pharmaceutical Crystals

Author: Tong Li

Publisher: John Wiley & Sons

Published: 2018-09-03

Total Pages: 578

ISBN-13: 1119046343

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An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.

ICH Quality Guidelines
ICH Quality Guidelines

Author: Andrew Teasdale

Publisher: John Wiley & Sons

Published: 2017-09-29

Total Pages: 624

ISBN-13: 1118971132

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Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. • Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies • Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implementation of ICH guidelines • Uses case studies to help readers understand and apply ICH guidelines • Provides valuable insights into guidelines development, with chapters by authors involved in generating or with experience implementing the guidelines • Includes coverage of stability testing, analytical method validation, impurities, biotechnology drugs and products, and good manufacturing practice (GMP)

Drug Stability for Pharmaceutical Scientists
Drug Stability for Pharmaceutical Scientists

Author: Thorsteinn Loftsson

Publisher: Academic Press

Published: 2014-01-25

Total Pages: 170

ISBN-13: 0124115624

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Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries. - Illustrates important theoretical concepts with numerous examples, figures, calculations, learning problems and questions for self-study and retention of material - Provides answers and explanations to test your knowledge - Enables you to better understand key concepts such as rate and order of reaction, reaction equilibrium, complex reaction mechanisms and more - Includes an in-depth discussion of both aqueous and solid drug solutions and contains the latest international regulatory requirements on drug stability

Handbook of Stability Testing in Pharmaceutical Development
Handbook of Stability Testing in Pharmaceutical Development

Author: Kim Huynh-Ba

Publisher: Springer Science & Business Media

Published: 2008-11-16

Total Pages: 389

ISBN-13: 0387856277

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This handbook is the first to cover all aspects of stability testing in pharmaceutical development. Written by a group of international experts, the book presents a scientific understanding of regulations and balances methodologies and best practices.

Photostabilization of Polymers
Photostabilization of Polymers

Author: J.F. Rabek

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 607

ISBN-13: 9400907478

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During the last two decades, the production of polymers and plastics has been increasing rapidly. In spite of developing new polymers and polymeric materials, only 40-60 are used commercially on a large scale. It has been estimated that half of the annual production of polymers is employed outdoors. Increasing the stability of polymers and plastics towards heat, light, atmospheric oxygen and other environmental agents and weathering conditions has always been a very important problem. The photochemical instability of most of polymers limits them to outdoor application, where they are photo degraded fast over periods ranging from months to a few years. To the despair of technologists and consumers alike, photodegrada tion and environmental ageing of polymers occur much faster than can be expected from knowledge collected in laboratories. In many cases, improved methods of preparation and purification of both monomers and polymers yield products of better quality and higher resistance to heat and light. However, without stabilization of polymers by applica tion of antioxidants (to decrease thermal oxidative degradation) and photostabilizers (to decrease photo-oxidative degradation) it would be impossible to employ polymers and plastics in everyday use.

The Syringe Driver
The Syringe Driver

Author: Andrew Dickman

Publisher: Oxford University Press

Published: 2016

Total Pages: 609

ISBN-13: 0198733720

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This book serves as a valuable reference source, providing a comprehensive review of syringe driver use and administration of drugs via CSCI, a safe and effective way of drug administration when other routes are inappropriate.

Drug Stability and Chemical Kinetics
Drug Stability and Chemical Kinetics

Author: Muhammad Sajid Hamid Akash

Publisher: Springer Nature

Published: 2020-11-01

Total Pages: 284

ISBN-13: 9811564264

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This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics.

Stability of Drugs and Dosage Forms
Stability of Drugs and Dosage Forms

Author: Sumie Yoshioka

Publisher: Springer Science & Business Media

Published: 2007-05-08

Total Pages: 274

ISBN-13: 0306468298

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Drug products are complex mixtures of drugs and excipients and, as such, their chemical and physical stability kinetics are complex. This book discusses the stability of these dosage forms with preformulation studies through to the studies on the final products. The book is intended for graduate students, researchers and professionals in the field of Pharmaceutics and Pharmaceutical Chemistry.