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Author: Neil A. Goldenberg
Publisher: Cambridge University Press
Published: 2015-01-08
Total Pages: 251
ISBN-13: 1107014549
DOWNLOAD EBOOKA comprehensive text summarizing current evidence and providing experienced perspectives on etiology, diagnosis, and management of pediatric thrombotic disorders.
Author: Brian R. Branchford
Publisher: Frontiers Media SA
Published: 2018-12-06
Total Pages: 116
ISBN-13: 2889456390
DOWNLOAD EBOOKVenous thromboembolism (VTE) occurs less often in children than adults and therefore remains underrecognized despite increasing in incidence. Due to the risk of mortality, short- and long-term morbidity, and increased healthcare costs associated with pediatric VTE, this entity merits better understanding and consideration. With this Research Topic, we aim to highlight some special considerations of pediatric VTE, namely risk factors and epidemiology, rare types of pediatric thrombosis and considerations unique to specific clinical patient subgroups, approaches to management and treatment, and prevention
Author: V.S. Blanchette
Publisher: Karger Medical and Scientific Publishers
Published: 2016-12-22
Total Pages: 360
ISBN-13: 3318030260
DOWNLOAD EBOOKThis updated and extended edition of the SickKids Handbook takes the reader through the entire field of pediatric thrombosis and hemostasis. An introductory section concisely explains the complex pathophysiology of thrombosis and hemostasis. The chapters that follow include practical, evidence-based information on the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children. Special features include practical clinical algorithms and appendices that cite normal laboratory reference ranges, as well as recommended dosages of blood products and major hemostatic agents. A stand-alone chapter is dedicated to developmental hemostasis and bleeding in the neonate. A chapter on antithrombotic therapy in children gives succinct information on the old and new anticoagulants, antiplatelet drugs and thrombolytic agents. Written and reviewed by international experts in the field, this handbook is intended for health care professionals involved in the assessment and care of children with inherited and acquired bleeding and clotting disorders, including general and specialist pediatricians (in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists), hematologists/oncologists (pediatric and adult), as well as medical trainees, nurses, nurse practitioners and pharmacists.
Author: Edward C.C. Wong
Publisher: Academic Press
Published: 2021-05-13
Total Pages: 1172
ISBN-13: 0128179635
DOWNLOAD EBOOKBiochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. Provides a fully-updated resource with more color illustrations Focuses on the biochemical and molecular basis of disease as well as the analytical techniques Defines important differences in the pathophysiology of diseases, comparing childhood with adult
Author: Robert Wynn
Publisher: Cambridge University Press
Published: 2017-02-16
Total Pages: 299
ISBN-13: 1107439361
DOWNLOAD EBOOKA succinct summary of the key principles and facts that guide the everyday practice of modern, clinical paediatric hematology. Covering all the information necessary for examinations in the topic, this book is ideal for postgraduates studying paediatric hematology, as well as for junior doctors in training.
Author: Maria Laura Avila
Publisher:
Published: 2016
Total Pages:
ISBN-13:
DOWNLOAD EBOOKObjectives: Post-thrombotic syndrome (PTS) is the most common long-term complication of upper and lower extremity (UE/LE) deep vein thrombosis (DVT). The objective of this thesis was to develop an index for diagnosis and severity rating of pediatric PTS. Methods: Separate sub-indexes were developed for UE and LE. First, a preliminary study was conducted to determine normal values of limb fluid content in children, using bioimpedance spectroscopy (BIS, Study 1); this information was used for item piloting in Study 2. Next, the signs and symptoms (items) to be included in each sub-index were obtained from a survey answered by an international panel of pediatric thrombosis experts and interviews to pediatric patients with PTS; the items were then defined and piloted in children with UE or LE-DVT to test their diagnostic performance and correlation with PTS diagnosis and severity, assessed by a pediatric thrombosis expert (Study 2). Last, the final items of the sub-indexes were voted by the expert panel using a Delphi process; a scoring system was then developed taking into account item importance to health care providers and to patients/parents, using multiple-criteria decision analysis (MCDA); the meaning of the scores was explored by comparing scores with PTS diagnosis and with parental satisfaction/dissatisfaction with the clinical condition of their child (Study 3). Results: Normal BIS values were obtained from 223 healthy children. Twenty-three experts and 16 patients with PTS identified 34 items, 32 of which fitted our measurement framework and were tested in children with UE-DVT (n=70) or LE-DVT (n=70). Aided by the obtained information on the diagnostic performance of each item, the pediatric thrombosis experts voted to retain 10 and 7 items for the LE and UE sub-indexes, respectively (81% response rate). Item weights were developed using MCDA (122 participants, 82% response rate). Both sub-indexes showed good discriminative ability to differentiate between patients with and without PTS. Higher scores were associated with parental dissatisfaction with the clinical condition of their child. Conclusion: We present an index for diagnosis and severity rating of pediatric PTS, developed using expert consensus. The tool provides a meaningful score and has proven diagnostic properties.
Author: Victor S. Blanchette
Publisher: Karger Medical and Scientific Publishers
Published: 2013
Total Pages: 274
ISBN-13: 3318021970
DOWNLOAD EBOOKSickKids Handbook of Pediatric Thrombosis and Hemostasis takes the reader through the entire field of paediatric thrombosis and hemostasis. This practical reference book will be a convenient, comprehensive, source of information and provides up-to-date, evidence-based guidance in the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children, including the neonate. Written and reviewed by international experts in the field, SickKids Handbook of Pediatric Thrombosis and Hemostasis will guide health care professionals involved in the assessment and care of children with all types of bleeding and clotting disorders, including general and specialist pediatricians, in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists; hematologists/oncologists as well as nurses, nurse practitioners and pharmacists. Written in a user-friendly, algorithmic approach, the resource will serve students and trainees and assist teachers in developing practical lessons.
Author:
Publisher:
Published: 2011
Total Pages: 204
ISBN-13:
DOWNLOAD EBOOKTo date, there is no definitive treatment for PTS in children and therapy is symptomatic. Therefore, the preferred approach to PTS in children is prevention. However, because it has only recently been of interest as a significant adverse DVT outcome in children and adolescents, there is a lack of available information about the risk factors of PTS development in children to prevent its development, especially those that can be modified with behavior or intervention. The purposes of this study are to: (1) identify the relationship between elevated body mass index (BMI) percentile and the incidence and severity of PTS following an episode of deep vein thrombosis, (2) determine if the relationship continues after controlling for genetic and acquired predisposing factors that may also influence the severity of PTS, and 3) identify a profile of children and adolescents at risk for developing PTS. This cross-sectional study was guided by an integration of the Health Promotion Model developed by Pender (1975) and Corbin and Strauss's Chronic Illness Trajectory Model (1987). The integration of these two well-established models provides a framework for considering the needs of acute exacerbations of PTS but also, the intermittent and uncertain chronic symptoms of the disease. Data for this study were extracted from a CDC thrombosis registry with children, from birth through 21 years of age, who were diagnosed with an extremity deep vein thrombosis (DVT). The data were analyzed using descriptive and cross-sectional analysis as well as developing a logistic regression model to find the best predictors for PTS development within this registry. A total of 557 pediatric subjects matched the inclusion criteria. The overall prevalence of PTS for this study was 20%. In this cohort of children, elevated BMI was found to be the best predictor within the logistic regression model that included possible risks for PTS, Elevated BMI in children with an extremity DVT was found to augment the risk of PTS development and severity. Infection, clot persistence and antiphospholipid antibody syndrome were also identified as potential predictors and were associated with higher risk of PTS when they co-occurred with obesity. Other potential predictors of PTS were extended time to diagnosis and treatment as well as the treatment type. Research in PTS suggests that there is merit in identifying predictors of PTS in pediatrics, and provides directions for future prevention efforts.
Author: Amy L. Dunn
Publisher: Springer Nature
Published: 2020-03-28
Total Pages: 223
ISBN-13: 3030316610
DOWNLOAD EBOOKThis clinical casebook provides a concise, state-of-the-art review of pediatric bleeding disorders. Presented in a case-based format, each case presents a different variant of bleeding disorder, illustrates the etiology, pathology, genetics, diagnosis, and management of the disorder, and offers clinical pearls. Disorders covered include hemophilia A and B, rare factor deficiencies, von Willebrand disease, immune thrombocytopenia purpura, and platelet dysfunctions. Written by experts in the field, Pediatric Bleeding Disorders: A Clinical Casebook is a valuable resource for clinicians and practitioners treating patients with challenging coagulation issues.
Author: Andrew, Bro Bro
Publisher: PMPH-USA
Published: 1997
Total Pages: 76
ISBN-13: 9781550090550
DOWNLOAD EBOOKHundreds of neonates and children are at risk for thrombotic complications related to interventions in cardiac and renal disease, treatments for leukemia and lupus, and ischemic stroke. The authors lay a foundation in the principles of hemostasis, congenital prethrombotic disorders, and the epidemiology of venous and arterial thromboembolism. The management protocols embrace heparin, oral anticoagulants, and thrombolytic therapy.
