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Author: Geoffrey W. Hoffman
Publisher: CRC Press
Published: 2019-08-15
Total Pages: 334
ISBN-13: 1000697053
DOWNLOAD EBOOKFirst published in 1986: Paradoxes play a key role in the advancement of science. They are associated with excitement, and with the knowledge that we must be looking at something the wrong way. This book discusses in detail Paradoxes in Immunology.
Author: Louis J. Catania
Publisher: Elsevier
Published: 2022-08-03
Total Pages: 284
ISBN-13: 0323951872
DOWNLOAD EBOOKThe Paradox of the Immune System: Protection, Inflammation, Autoimmune Disease and Beyond provides a provocative approach to immunology as a "double-edged sword." While it is our greatest protector, it is also the cause of chronic inflammation that leads to autoimmune disease, cancer and infectious diseases like COVID-19. Sections cover the basic science of immunology and its intimate genetic associations, biomedical hypotheses asserting immunology as the basis of all human diseases, and elaborate on immunology as "the enemy within us." This engaging, original approach to a science so personal provides new and invaluable understanding on the bioscience that controls our lives. Written in an expository style that allows for maximum understanding of the complex science presented Presents the unfolding of immunology from a natural (innate) system into an adaptive system leading to chronic inflammation and ultimate disease Provides readers with a unique perspective on health, wellness and disease
Author: Thomas Pradeu
Publisher: OUP USA
Published: 2012-02-27
Total Pages: 313
ISBN-13: 0199775281
DOWNLOAD EBOOKImmunology asserts that an individual can be defined through self and nonself. Thomas Pradeu argues that this theory is inadequate, because immune responses to self constituents and immune tolerance of foreign entities are the rule, not the exception.
Author: Wendy K. Smith
Publisher: Oxford University Press
Published: 2017-09-07
Total Pages: 625
ISBN-13: 019106937X
DOWNLOAD EBOOKThe notion of paradox dates back to ancient philosophy, yet only recently have scholars started to explore this idea in organizational phenomena. Two decades ago, a handful of provocative theorists urged researchers to take seriously the study of paradox, and thereby deepen our understanding of plurality, tensions, and contradictions in organizational life. Studies of organizational paradox have grown exponentially over the past two decades, canvassing varied phenomena, methods, and levels of analysis. These studies have explored such tensions as today and tomorrow, global integration and local distinctions, collaboration and competition, self and others, mission and markets. Yet even with both the depth and breadth of interest in organizational paradoxes, key issues around definitions and application remain. This Handbook seeks to aid, engage, and fuel the expanding interest in organizational paradox. Contributions to this volume depict how paradox studies inform, and are informed, by other theoretical perspectives, while creating a resource that enables scholars to learn about and apply this lens across varied organizational phenomena. The increasing complexity, volatility, and ambiguity in our world continually surfaces paradoxical dynamics. Thus, this Handbook offers insights to scholars across organizational theory.
Author: Geoffrey W. Hoffmann
Publisher: Springer Science & Business Media
Published: 2013-06-29
Total Pages: 250
ISBN-13: 3642516912
DOWNLOAD EBOOKIn February 1985 a small international meeting of scientists took place at the recreation resort of the Polish Academy of Sci ences in Mogilany, near Cracow, Poland. The initiative for holding the workshop came from a working meeting on mathematical immunology and related topics at the International Institute for Applied Sys tems Analysis in Laxenburg, Austria, in November 1983. In addition to representatives of IIASA, delegates of the IIASA National Member Organizations (NMO) of Czechoslovakia, Italy, and the soviet Union took part in that working meeting. The participants came to the conclusion that IIASA could play an important role in facilitating the development of research in this field. The first step that they recommended to I IASA was to organize a workshop on mathematical immunology. The purpose of the workshop was to review the progress that has been made in applying mathematics to problems in immunology and to explore ways in which further progress might be achieved, especially by more efficient interactions between scientists working in mathematical and experimental immunology. Some National Member Organizations contributed to the success of the workshop by nominat ing further participants working in this or related fields. For instance, thanks to a suggestion of the British NMO, the meeting also included analyses of the interactions between the immune state of a population and epidemiological phenomena. There were 33 participants at Mogilany from 11 countries, namely Canada, Czechoslovakia, Federal Republic of Germany, Hungary, Japan, Netherlands, Poland, Sweden, united Kingdom, USA, and USSR.
Author: Per-Ulf Tunn
Publisher: Springer Science & Business Media
Published: 2008-12-28
Total Pages: 372
ISBN-13: 3540779604
DOWNLOAD EBOOKBone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.
Author: Alain Beschin
Publisher: Springer
Published: 2012-11-22
Total Pages: 184
ISBN-13: 9783642622366
DOWNLOAD EBOOKBased on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.
Author: Narinder Kapur
Publisher: Cambridge University Press
Published: 2011-07-21
Total Pages: 489
ISBN-13: 1139495798
DOWNLOAD EBOOKThe Paradoxical Brain focuses on a range of phenomena in clinical and cognitive neuroscience that are counterintuitive and go against the grain of established thinking. The book covers a wide range of topics by leading researchers, including: • Superior performance after brain lesions or sensory loss • Return to normal function after a second brain lesion in neurological conditions • Paradoxical phenomena associated with human development • Examples where having one disease appears to prevent the occurrence of another disease • Situations where drugs with adverse effects on brain functioning may have beneficial effects in certain situations A better understanding of these interactions will lead to a better understanding of brain function and to the introduction of new therapeutic strategies. The book will be of interest to those working at the interface of brain and behaviour, including neuropsychologists, neurologists, psychiatrists and neuroscientists.
Author: Louis J. Catania
Publisher: Academic Press
Published: 2022-08-06
Total Pages: 286
ISBN-13: 0323951880
DOWNLOAD EBOOKThe Paradox of the Immune System: Protection, Inflammation, Autoimmune Disease and Beyond provides a provocative approach to immunology as a "double-edged sword." While it is our greatest protector, it is also the cause of chronic inflammation that leads to autoimmune disease, cancer and infectious diseases like COVID-19. Sections cover the basic science of immunology and its intimate genetic associations, biomedical hypotheses asserting immunology as the basis of all human diseases, and elaborate on immunology as "the enemy within us." This engaging, original approach to a science so personal provides new and invaluable understanding on the bioscience that controls our lives. - Written in an expository style that allows for maximum understanding of the complex science presented - Presents the unfolding of immunology from a natural (innate) system into an adaptive system leading to chronic inflammation and ultimate disease - Provides readers with a unique perspective on health, wellness and disease
Author: Gerd Pluschke
Publisher: Springer
Published: 2019-04-29
Total Pages: 290
ISBN-13: 3030111148
DOWNLOAD EBOOKA major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.
