PA28y Affects Cellular Resolution of Oxidative DNA Damage
Author: Bethany E. Bundrant
Publisher:
Published: 2018
Total Pages: 132
ISBN-13:
DOWNLOAD EBOOKSummary: Increased levels of reactive oxygen species (ROS) are present in almost all cancers. Since increased levels of ROS can cause serious damage to nucleic acids, carbohydrates, lipids and proteins, understanding how cancer cells sustain their altered biology could identify ways to selectively target transformed cells. ... Here, we identify an expanded role for PA28y in the cellular response to oxidative stress. ... Taken together, our data reveal an expanded role for PA28y in the cellular response to oxidative damage, perhaps playing an important role in the recognition of oxidatively-damaged DNA. -- Abstract.