Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine

Author: Robert C. Bast, Jr.

Publisher: John Wiley & Sons

Published: 2017-03-10

Total Pages: 2004

ISBN-13: 111900084X

DOWNLOAD EBOOK

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Oncogenes, Aneuploidy, and AIDS
Oncogenes, Aneuploidy, and AIDS

Author: Harvey Bialy

Publisher: North Atlantic Books

Published: 2004

Total Pages: 332

ISBN-13: 9781556435317

DOWNLOAD EBOOK

According to author Harvey Bialy, the work of molecular biologist Peter Duesberg has been grossly distorted by the media and scientific establishments. Until recently, the scientific community--and most notably, those from the National Institute for Health--have been unwilling to look at his provocative theories of different causes for cancer and HIV/AIDS. Inspired by UC Berkeley's rare creation of an archive for Duesberg's papers, this book explores Duesberg's early groundbreaking work with viruses and oncogenes, his contentious fights with other scientists, and the profound influence of his life's work.

Adaptive Oncogenesis
Adaptive Oncogenesis

Author: James DeGregori

Publisher: Harvard University Press

Published: 2018-03-09

Total Pages: 289

ISBN-13: 0674545397

DOWNLOAD EBOOK

Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancerÕs occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the bodyÕs tissues. His theory ties cancerÕs progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genesÑbut not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cellsÕ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a speciesÕ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregoriÕs perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissuesÕ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

The Oncogene and Tumour Suppressor Gene Factsbook
The Oncogene and Tumour Suppressor Gene Factsbook

Author: Robin Hesketh

Publisher: Elsevier

Published: 1997-07-11

Total Pages: 564

ISBN-13: 0080538002

DOWNLOAD EBOOK

The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. - Includes much new data on this fast-moving field, including newly discovered oncogenes - Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes - Contains more than 2000 terms for reference and further research - Revised to included signaling pathways, apoptosis, and metastasis

The Art and Politics of Science
The Art and Politics of Science

Author: Harold Varmus

Publisher: W. W. Norton & Company

Published: 2010-05-24

Total Pages: 330

ISBN-13: 0393073564

DOWNLOAD EBOOK

A Nobel Prize–winning cancer biologist, leader of major scientific institutions, and scientific adviser to President Obama reflects on his remarkable career. A PhD candidate in English literature at Harvard University, Harold Varmus discovered he was drawn instead to medicine and eventually found himself at the forefront of cancer research at the University of California, San Francisco. In this “timely memoir of a remarkable career” (American Scientist), Varmus considers a life’s work that thus far includes not only the groundbreaking research that won him a Nobel Prize but also six years as the director of the National Institutes of Health; his current position as the president of the Memorial Sloan-Kettering Cancer Center; and his important, continuing work as scientific adviser to President Obama. From this truly unique perspective, Varmus shares his experiences from the trenches of politicized battlegrounds ranging from budget fights to stem cell research, global health to science publishing.

Human Oncogenic Viruses
Human Oncogenic Viruses

Author: Jing-hsiung James Ou

Publisher: World Scientific

Published: 2010

Total Pages: 354

ISBN-13: 9812833471

DOWNLOAD EBOOK

Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and the cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, EpsteinOCoBarr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers. Sample Chapter(s). Foreword (38 KB). Chapter 1: Oncogenic Viruses, Cellular Transformation and Human Cancers (211 KB). Contents: Oncogenic Viruses, Cellular Transformation and Human Cancers (Y-Y Zheng & J-H J Ou); Hepatitis B Virus and Hepatocellular Carcinogenesis (T S B Yen); Molecular Mechanism of Hepatitis C Virus Carcinogenesis (K Machida et al.); Human Papillomaviruses and Associated Malignancies (C L Nguyen et al.); Epstein-Barr Virus and Its Oncogenesis (H-P Li et al.); Human Kaposi's Sarcoma-associated Herpesvirus: Molecular Biology and Oncogenesis (P J Dillon & B Damania); Human T-Cell Leukemia Virus 1 and Cellular Transformation (Y-H Chi & K-T Jeang). Readership: Graduate students and postdoctoral fellows in infectious diseases, microbiology/virology, oncology/cancer research, and cell/molecular/structural biology; medical students, physicians and non-experts who are interested in understanding the relationship between oncogenic viruses and the cancers they cause

One Renegade Cell
One Renegade Cell

Author: Robert A Weinberg

Publisher: Basic Books

Published: 2008-08-04

Total Pages: 180

ISBN-13: 0786724013

DOWNLOAD EBOOK

Cancer research has reached a major turning point. The quality and quantity of information gathered about this disease in the past twenty years has revolutionized our understanding of its origins and behavior. No one is better qualified to comment on these dramatic leaps forward than molecular biologist Robert A. Weinberg, director of one of the leading cancer research centers in the world. In One Renegade Cell , Weinberg presents an accessible and state-of-the-art account of how the disease begins and how, one day, it will be cured. Weinberg tells how the roots of cancer were uncovered in 1909 and when the first cancer-causing virus was discovered. He then moves forward to the discovery of the role of chemical carcinogens and radiation in triggering cancer, and relates the remarkable story of the discoveries of oncogenes and tumor suppressor genes, the master controllers of normal and malignant cell proliferation. This book, which presumes little prior knowledge of biology, describes the revolution in biomedical research that has finally uncovered the forces driving malignant growth. Drawing on insights that simply were not available until recently, the discoveries presented in One Renegade Cell have already begun to profoundly alter the way that we diagnose and treat human cancers.

Human Herpesviruses
Human Herpesviruses

Author: Ann Arvin

Publisher: Cambridge University Press

Published: 2007-08-16

Total Pages: 1325

ISBN-13: 1139461648

DOWNLOAD EBOOK

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.