Nutrition and Gastrointestinal Disease

Nutrition and Gastrointestinal Disease

Author: Mark H. DeLegge

Publisher: Springer Science & Business Media

Published: 2007-10-15

Total Pages: 338

ISBN-13: 1588298086

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Nutritional support of people with gastrointestinal impairment is critical to treatment and ultimately successful management. As such, gastroenterologists should be experts in nutrition and knowledgeable about the affects of nutrition on disease management. Nutritional and Gastrointestinal Disease fulfills that need, serving as a hands-on, practical reference in nutrition support for the clinical gastroenterologist and other clinicians with similar interests. The volume offers expert nutritional knowledge and management ideas as well as methodology for combating problems such as short bowel syndrome, inflammatory bowel disease, celiac disease and obesity. Renowned authorities also investigate nutrition’s influence on such issues as liver failure and acute pancreatitis. While gastroenterology training programs around the world remain deficient in their nutrition curriculum, Nutritional and Gastrointestinal Disease provides a comprehensive and groundbreaking support for clinical gastroenterologists.


The Sensitive Gut

The Sensitive Gut

Author: Michael Lasalandra

Publisher: Simon and Schuster

Published: 2001-12-11

Total Pages: 230

ISBN-13: 0743215044

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Looks at ways to prevent and treat such disorders as dyspepsia, reflux disease, irritable bowl syndrome, constipation, and diarrhea.


Colonic Motility

Colonic Motility

Author: Sushil K. Sarna

Publisher: Biota Publishing

Published: 2010-11-01

Total Pages: 159

ISBN-13: 1615041516

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Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.


Sleisenger & Fordtran's Gastrointestinal and Liver Disease

Sleisenger & Fordtran's Gastrointestinal and Liver Disease

Author: Mark Feldman

Publisher:

Published: 2006

Total Pages: 2889

ISBN-13: 9781416002451

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Provide evidence-based perspectives on all clinically relevant topics, explaining step by step how to apply the latest advances in practice. Succinct yet comprehensive discussions provide just the right amount of clinical detail. Plus, a consistent organization and full-color art program enable you to quickly and easily access needed information. Offers more than 1,000 illustrations, photographs, and tables (400 in full color) that promote a visual grasp of the material. Presents coverage of the hottest topics in today's practice, including GERD, non-alcoholic fatty liver disease, ulcerative colitis, and Barretts esophagus, as well as the psychosocial aspects of gastrointestinal and liver diseases. Features four new chapters covering complimentary and alternative medicine palliative care gastrointestinal stromal tumor (GIST) and eosinophilic disorders, plus expanded information on obesity and nutrition.


Stomach Ailments and Digestive Disturbances

Stomach Ailments and Digestive Disturbances

Author: Michael T. Murray

Publisher: Prima Lifestyles

Published: 1997

Total Pages: 0

ISBN-13: 9780761506577

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Everyone suffers from occasional stomach ailments and indigestion. As we age, these problems often increase in frequency and severity. You?ve probably tried those expensive new over-the-counter antacids or inexpensive tablets; but did you know those chemical remedies inhibit digestion instead of helping it? They mask the symptoms instead of treating the causes. Now one of the most respected names in the field of natural medicine offers real solutions. Dr. Michael T. Murray, co-author of the acclaimed "Encyclopedia of Natural Medicine, explains how our digestive system works. He evaluates the conventional medications used to treat it and offers effective, natural alternatives you can trust. You will learn how to: - Work with your digestive system, not against it - Use natural nutritional supplements to improve digestion - Avoid heartburn, peptic ulcers, and intestinal disorders - Promote better digestion through exercise - Identify and avoid foods that can cause allergic reactions - Enjoy a nutritious, delicious diet that supports your body's natural functions - And much, much more! Proper digestion is as vital as breathing; it allows us to absorb all the nutrients we need to live. With Dr. Murray's clear, specific recommendations, you will enhance your digestion--naturally!


The Gastrointestinal Circulation

The Gastrointestinal Circulation

Author: Peter R. Kvietys

Publisher: Morgan & Claypool Publishers

Published: 2010

Total Pages: 127

ISBN-13: 1615041176

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The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography