This issue of Immunology and Allergy Clinics, devoted to Obesity and Asthma, is edited by Dr. Anurag Agrawal. Articles in this issue include: Clinical Implications of the Obese Asthma Phenotypes; Childhood Obesity and the Risk of Allergy; Metabolic Asthma: Is there a link between obesity, asthma, and diabetes?; Role of Weight Management in Obese-Asthma Control; Obesity and Airway Disease: A Bioenergetic Problem?; Nutrition, Obesity, and Asthma: Exploring Epigenetic Programming; Obesity and Asthma: The Role of Environmental Pollutants; Novel Therapeutic Strategies for Adult Obese Asthmatics; and From ADMA to Asthma.
This issue of Immunology and Allergy Clinics is devoted to Asthma in Childhood and is Guest Edited by Drs. Leonard Bacharier and Theresa Guilbert. Articles in this outstanding issue include: Inception and Natural History of Pediatric Asthma; Recent Diagnosis Techniques in Pediatric Asthma; Management / co-morbidities for Preschool-aged Children with Asthma; Management/ co-morbidities for School-aged Children with Asthma; Effects of the Environment on Disease Activity; New Advances of Self-Management/Adherence Monitoring and Management in Pediatric Asthma; Severe Asthma in Early Childhood; Inner-city Asthma in Early Childhood; Personalized Medicine and Pediatric Asthma; Prevention in Pediatric Asthma; Asthma in the Schools; and New Directions in Pediatric Asthma.
This issue of Immunology and Allergy Clinics of North America, guest edited by Dr. Rohit Katial, is devoted to Severe Asthma. Articles in this issue include: Epidemiology and Pulmonary Physiology of Severe Asthma; Linkage and Genetic Associations in Severe Asthma; Asthma COPD Overlap Syndrome (ACOS); Biomarkers in Severe Asthma; Imaging in Severe Asthma; Eosinophilic Phenotype; Neutrophilic and Pauci-immune Phenotypes; Role of Sleep Apnea and Gastroesophageal Reflux Disease in Severe Asthma; Role of Small Airways in Severe Asthma; Chronic Infection and Severe Asthma; Chronic Rhinosinusitis and Aspirin Associated Respiratory Disease; Psychosocial Factors in Severe Asthma; Traditional Therapies for Severe Asthma; and Emerging Biologics for Severe Asthma.
This issue of Immunology and Allergy Clinics, guest edited by Drs. Flavia Hoyte and Rohit Katial, is devoted to Biomarkers in Allergy and Asthma. Articles in this issue include: Exhaled Nitric Oxide; Biomarkers in Exhaled Breath Condensate (EBC); Role of Eosinophils in Asthma; Bronchoprovocation Testing in Asthma; Periostin and DPP4; Role of Neutrophils in Asthma; Urinary LTE4; Biomarkers in Nasal Polyps; IgE as a Biomarker in Asthma; Genetics of Asthma; and Biomarker-directed Therapies for Asthma.
This issue of Immunology and Allergy Clinics, Guest Edited by Dr. Mitchell Grayson, is devoted to Infections and Asthma. Articles in this issue include: Epidemiology of Infections and Development of Asthma; Mechanisms of Respiratory Syncytial Virus Induced Asthma; Importance of Viral Characteristics in Respiratory Syncytial Virus Induced Disease; Human Rhinovirus and Asthma Exacerbation; Rhinovirus Attributes That Contribute to Asthma; Infant Immune Response to Respiratory Viral Infections; The Role of Bacteria in Asthma Pathogenesis; Beyond RSV and RV in the Pathogenesis and Exacerbation of Asthma; Biologics for Asthma and Risk of Infection: Should We Be Concerned?; Sinus Infections and Asthma; Helminths and Asthma: Friend or Foe?; and Primary Infection Prevention Strategies for Asthma.
Pediatric studies of associations among obesity, asthma and allergic sensitization are inconclusive. Body mass index (BMI) is commonly used to classify study participants as obese. BMI, however, does not reflect central fat distribution, a known risk factor for metabolic disorders. This research tested the hypothesis that central fat distribution increases risk for asthma and allergic sensitization, measured using the skin prick test for aeroallergens. Measures of central fat distribution included waist circumference, waist to height ratio (WHtR) and conicity index. Childhood studies rarely utilize these alternative measures for characterizing the relationship between obesity and asthma or allergic sensitization. In this study, alternative measures of obesity were compared with BMI percentiles; the association between obesity and asthma in children with allergic rhinitis was investigated; the association between obesity and allergic sensitization in children with and without asthma, rhinitis and eczema was explored. To account for the effects of several obesity measures on the above outcomes, a structural equation model was developed. Results show that BMI percentiles are discordant with 18-46% of children classified as obese using the alternative measures. A high WHtR or conicity index increases likelihood for asthma in children with allergic rhinitis. Prevalence of a high WHtR consistently increases from allergic rhinitis to mild asthma to moderate/severe asthma. Sensitization to aeroallergens appears to protect against an asthma diagnosis (OR=0.6; 95% CI=0.4-0.9), but is positively associated with rhinitis (OR=8.1; 95% CI=4.9-13.5) and eczema (OR=1.9; 95% CI=1.0-3.4). In children with rhinitis, those with a moderate WHtR are twice as likely to have increasing positive skin prick tests (OR=1.9; 95% CI=1.1-3.3) compared to low WHtR. In children with asthma, obesity appears to protect against increasing positive skin prick tests per BMI percentiles (OR=0.5; 95% CI=0.3-0.9) or waist circumference (OR=0.3; 95% CI=0.1-0.9). This finding suggests that the pathway for asthma is different in children with central obesity. Alternative measures that better account for fat distribution are superior to BMI percentiles for characterizing the relationship between childhood obesity with asthma and with allergic sensitization in the context of asthma, rhinitis and eczema.
This issue of Immunology and Allergy Clinics is devoted to Asthma in Childhood and is Guest Edited by Drs. Leonard Bacharier and Theresa Guilbert. Articles in this outstanding issue include: Inception and Natural History of Pediatric Asthma; Recent Diagnosis Techniques in Pediatric Asthma; Management / co-morbidities for Preschool-aged Children with Asthma; Management/ co-morbidities for School-aged Children with Asthma; Effects of the Environment on Disease Activity; New Advances of Self-Management/Adherence Monitoring and Management in Pediatric Asthma; Severe Asthma in Early Childhood; Inner-city Asthma in Early Childhood; Personalized Medicine and Pediatric Asthma; Prevention in Pediatric Asthma; Asthma in the Schools; and New Directions in Pediatric Asthma.
Guest edited by Eugene Choo, this issue of Immunology and Allergy Clinics covers the latest research in diagnosing and managing asthma-like diseases. Topics covered include vocal cord dysfunction, dynamic airway collapse, RADS, GERD, sarcoidosis, and more.
In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize
In this issue of Immunology & Allergy Clinics, guest editors Drs. Rosalind Wright and Jeffrey Demain bring their considerable expertise to the topic of Climate Change and Allergy. Warming temperatures and increasing carbon dioxide from fossil fuels are contributing to more intense allergies. In this issue, top experts discuss the effects of climate change, including its impacts to food, water, and both indoor and outdoor air. Contains 11 relevant, practice-oriented topics including nutrition and ecology; exposome and chemical exposure related to climate-related weather changes[RM1] ; psychological impacts of climate change and atopic disease; climate change and food allergy; extreme weather and asthma; and more. Provides in-depth clinical reviews on climate change and allergy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
