Cadmium in the Human Environment
Cadmium in the Human Environment

Author: Gunnar Nordberg

Publisher:

Published: 1992

Total Pages: 500

ISBN-13:

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Cadmium is widely dispersed in the environment. Human exposure to low levels occur as a result of natural processes as well as human activities such as mining, smelting, fossil fuel combustion and industrial use. Pollution of the general environment by cadmium has as yet only been related to the development of human disease in some special situations, such as itai-itai disease and renal dysfunction in Belgium and in China. However, the possibility of more widespread contamination and greater mobility of cadmium in the environment on the one hand and the advent of new data concerning the carcinogenicity of cadmium on the other, make this review of the "state of the art" in human risk identification and assessment timely. Recent studies on human exposure to cadmium metabolism and toxicology, renal dysfunction and related effects, and experimental and epidemiological evidence for carcinogenicity of cadmium are described.

Industrial Guide to Chemical and Drug Safety
Industrial Guide to Chemical and Drug Safety

Author: T. S. S. Dikshith

Publisher: John Wiley & Sons

Published: 2003-05-27

Total Pages: 659

ISBN-13: 0471458775

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Exposure to a wide variety of chemicals and drugs has become common in industrial, laboratory, and even household environments. Fortunately, global understanding and consequently global safety standards regarding the management of toxic and hazardous substances are fast approaching uniformity. The methods of handling, use, transportation, storage, and disposal in particular are moving toward standardization. As these protocols involving chemicals and drugs continue to cross international borders, students and professionals need a reliable resource to ensure they observe appropriate safety standards. The Industrial Guide to Chemical and Drug Safety covers not only current standards, but also a wealth of information on toxins to help regulatory bodies develop new protocols. Written in an accessible narrative style, the Guide covers chemicals by key classes such as solvents, pesticides, and metals, and also by key industries such as drugs, food additives, plastics, cosmetics, detergents, and soaps. The book explains the beneficial and harmful aspects of a broad range of materials to which students, trainees, skilled workers, managers, and personnel associated with regulatory agencies are exposed, with the purpose of helping them avoid the illnesses associated with the misuse of chemicals and drugs. Chapters include: -Heavy Metals -Pesticides -Industrial Solvents -Industrial Gases and Fumes -Drugs -Target Organ Toxicity -Disposal of Hazardous Chemicals -Guidance to Students and Workers -Good Laboratory Practice

The Molecular Basis of Human Cancer
The Molecular Basis of Human Cancer

Author: William B. Coleman

Publisher: Humana Press

Published: 2016-11-11

Total Pages: 868

ISBN-13: 1597454583

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This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

The Secret History of the War on Cancer
The Secret History of the War on Cancer

Author: Devra Davis

Publisher: PublicAffairs

Published: 2009-02-24

Total Pages: 562

ISBN-13: 0465015689

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From the National Book Award finalist and author of "When Smoke Ran Like Water" comes this searing, haunting, and deeply personal account of how a major public health effort was diverted and distorted for private gain.

Peroxisome Proliferation and Its Role in Carcinogenesis
Peroxisome Proliferation and Its Role in Carcinogenesis

Author:

Publisher: World Health Organization

Published: 1995

Total Pages: 104

ISBN-13:

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A state-of-the-art consensus report on what is known about peroxisome proliferation, the mechanisms involved, and their relevance to carcinogenesis. Peroxisomes are single, membrane-limited, cytoplasmic organelles that are found in cells of animals, plants, fungi, and protozoa. Peroxisome proliferators include certain hypolipidaemic drugs, phthalate ester plasticizers, industrial solvents, herbicides, food flavours, leukotriene D4 antagonists, and hormones. Numerous studies in rats and mice have demonstrated the hepatocarcinogenic effects of peroxisome proliferators, and these compounds have been unequivocally established as carcinogens. Since humans are exposed to peroxisome proliferators to a significant extent, assessment of the adverse biological effects of this group of compounds, and particularly their potential carcinogenicity, has become an important issue. The report has two parts. The first records the consensus reached by a group of eleven experts, including several of the leading investigators in this field. Questions addressed include the mechanisms by which peroxisome proliferators exert their carcinogenic effects in rodents, the relevance of animal studies to the evaluation of carcinogenic risk in humans, and the potential use of peroxisome proliferation as a biological marker for liver cancer. The report concludes that compounds inducing peroxisome proliferation in rats and mice have little, if any, effect on human liver. The report also issues advice on the interpretation of peroxisome proliferation, demonstrated in animal studies, when evaluating the carcinogenic risk to humans. The second part consists of three background papers presented by members of the working group.