Technical Report on Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Technical Report on Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Author: P. C. Chan

Publisher: DIANE Publishing

Published: 2009-09

Total Pages: 206

ISBN-13: 1437914543

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Cumene is produced in a modified Friedel-Crafts reaction process. Cumene is the principal chemical used in the production of phenol and acetone. Cumene is used: as a thinner; as a constituent of some petroleum-based solvents; in gasoline blending, diesel fuel, and high-octane aviation fuel; and as a raw material for peroxides and oxidation catalysts. Because cumene is a good solvent for fats and resins, it has been suggested as a replacement for benzene in many industrial applications. Cumene occurs naturally in petroleum and in a variety of foodstuffs. Cumene was nominated for study because of its high production volume, presence in gasoline and other fuels, potential for human exposure, and lack of existing carcinogenecity test data. Illus.

Boorman's Pathology of the Rat
Boorman's Pathology of the Rat

Author: Andrew W. Suttie

Publisher: Academic Press

Published: 2017-12-01

Total Pages: 750

ISBN-13: 0123914892

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Boorman's Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. - Contains full, four color photographs from the NTP archive and database and coverage of all rat strains - Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes - Includes comprehensive and detailed background incidence data - Presents detailed descriptive content regarding changes in rat models during research

Mutagenic Impurities
Mutagenic Impurities

Author: Andrew Teasdale

Publisher: John Wiley & Sons

Published: 2022-02-15

Total Pages: 548

ISBN-13: 1119551218

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Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.

WHO Monographs on Selected Medicinal Plants
WHO Monographs on Selected Medicinal Plants

Author: World Health Organization

Publisher: World Health Organization

Published: 1999

Total Pages: 392

ISBN-13: 9789241545372

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This is the second volume in a series of monographs which are intended to promote information exchange and international harmonised standards for the quality control and use of herbal medicines. It contains scientific information on 30 selected plants, and each entry includes a pharmacopoeial summary for quality assurance purposes, information on its clinical application and sections on contraindications, pharmacology, safety issues, and dosage forms. It provides two cumulative indexes with entries in alphabetical order by plant name and according to the plant material of interest.

Chemistry and Analysis of Volatile Organic Compounds in the Environment
Chemistry and Analysis of Volatile Organic Compounds in the Environment

Author: H.J. Bloemen

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 304

ISBN-13: 9401121524

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Interest in the occurrence and behaviour of volatile organic compounds (VOCs) is increasing due to their adverse effects on the environment and human health. It is essential that information is made available on the various aspects of research on VOCs to enable better understanding and control of the various environmental and human health threats. The information in this book will be used to improve communication and understanding of the various approaches. In particular the potential and limitations of the described analytical methods will be essential in defining environmental studies and interpreting the results.