Nimesulide - Actions and Uses
Nimesulide - Actions and Uses

Author: K. D. Rainsford

Publisher: Springer Science & Business Media

Published: 2006-01-16

Total Pages: 445

ISBN-13: 3764374101

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Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs. The chapters are written by leading experts and cover development of nimesulide, including synthesis and production, introduction, and approved uses and applications, followed by pharmacokinetics and toxicological properties, adverse reactions and their mechanisms.

Hepatotoxicity
Hepatotoxicity

Author: Hyman J. Zimmerman

Publisher: Lippincott Williams & Wilkins

Published: 1999

Total Pages: 850

ISBN-13: 9780781719520

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Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Drug-Induced Liver Injury
Drug-Induced Liver Injury

Author:

Publisher: Academic Press

Published: 2019-07-13

Total Pages: 290

ISBN-13: 0128173173

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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Security Technology Convergence Insights
Security Technology Convergence Insights

Author: Ray Bernard

Publisher: Elsevier

Published: 2015-04-02

Total Pages: 160

ISBN-13: 0128030011

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Security technology convergence, which refers to the incorporation of computing, networking, and communications technologies into electronic physical security systems, was first introduced in the 1970s with the advent of computer-based access control and alarm systems. As the pace of information technology (IT) advances continued to accelerate, the physical security industry continued to lag behind IT advances by at least two to three years. Security Technology Convergence Insights explores this sometimes problematic convergence of physical security technology and information technology and its impact on security departments, IT departments, vendors, and management. - Includes material culled directly from author's column in Security Technology Executive - Easy-to-read question and answer format - Includes real-world examples to enhance key lessons learned

Textbook of Rabbit Medicine
Textbook of Rabbit Medicine

Author: Molly Varga Smith

Publisher: Elsevier Health Sciences

Published: 2013-08-19

Total Pages: 507

ISBN-13: 0702054194

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The Textbook of Rabbit Medicine second edition is the completely revised and updated new edition of Frances Harcourt Brown’s acclaimed text covering all aspects of rabbit medicine. While the authoritative and evidence-based approach that made the original book so successful has been retained, in this new second edition well-known rabbit expert Molly Varga adds a stronger clinical focus that makes the Textbook invaluable as a point-of-care resource as well as a respected reference. With many additional features introduced for this update, the Textbook of Rabbit Medicine second edition remains the definitive and comprehensive reference of choice for all veterinary practitioners seeking information on the pet rabbit. Comprehensive, in-depth and authoritative coverage of the health and diseases of the domestic rabbit Detailed and explicit line artwork provides a clear understanding of physiological processes A practical, evidence-based resource for the effective treatment of pet rabbits. New to the second edition A new expert author revises and reframes the original classic text for today’s practitioners and students Content is thoroughly updated to include the latest drugs, anaesthetics and techniques A new full-colour design is used to improve access and navigability Many new colour illustrations and diagrams throughout help emphasize and clarify key content The book’s additional clinical emphasis makes this edition more practical than ever before!

Advances in Eicosanoid Research
Advances in Eicosanoid Research

Author: C.N. Serhan

Publisher: Springer Science & Business Media

Published: 2000-04-10

Total Pages: 300

ISBN-13: 9783540667476

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Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.

Fundamentals of Anaesthesia
Fundamentals of Anaesthesia

Author: Colin Pinnock

Publisher: Cambridge University Press

Published: 2002-12

Total Pages: 990

ISBN-13: 9780521690799

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The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.

Selective COX-2 Inhibitors
Selective COX-2 Inhibitors

Author: Sir John R. Vane

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 153

ISBN-13: 9401148724

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The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are two distinct isoforms of COX, a constitutive enzyme (COX-I) responsible for the production of prostanoids necessary for platelet aggregation and protection of the gastric mucosa and kidney; and an inducible enzyme (COX-2) that is newly synthesized at sites of tissue damage and produces prostaglandins that manifest pathological effects. It became clear that different NSAIDs had greater or lesser effects on COX-I when used in therapeutic doses, explaining the variation in side-effects. ' The elucidation of the crystal structure of these different enzymes and the skills of medicinal chemists have led to the synthesis of new chemicals with a selectivity for the inducible enzyme, and thus with therapeutic efficacy without those toxic effects result ing from inhibition of the constitutive enzyme.

Anesthetic Pharmacology
Anesthetic Pharmacology

Author: Alex S. Evers

Publisher: Cambridge University Press

Published: 2011-03-10

Total Pages: 2902

ISBN-13: 1139497022

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In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

The Chest X-Ray: A Survival Guide
The Chest X-Ray: A Survival Guide

Author: Gerald de Lacey

Publisher: Elsevier Health Sciences

Published: 2012-05-25

Total Pages: 385

ISBN-13: 0702051071

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British Medical Association Book Awards 2009 - First Prize Winner, Radiology Category Featuring a practical, clinical approach – and written in a quick-access style – this portable, economical reference helps you build a strong foundation in chest x-ray interpretation. Three radiologists with years of clinical and teaching experience present fundamental principles and key anatomical concepts...walk you through examples of classic chest x-ray features that provide subtle evidence of abnormality...and explore a variety of problems and dilemmas common to everyday clinical practice. High-quality drawings and digital chest x-rays – combined with secrets from the radiologists' toolbox, helpful differential diagnoses, handy checklists, and key references – deliver all the assistance you need to enhance your interpretation skills. - Provides a strong foundation of essential knowledge for an informed, systematic approach to accurate chest x-ray interpretation. - Features the work of three radiologists who offer you the benefit of their many years of clinical and teaching experience. - Emphasizes common errors and misdiagnoses to help ensure correct image readings. - Presents step-by-step guidance in a bulleted, quick-access format, in short chapters focused on clinical problems, to make it easy to master the information that you need to know. - Makes difficult anatomic concepts easier to grasp by pairing radiographs with color line drawings. - Explains the nomenclature special to the field through a glossary of important terms. - Highlights the most important concepts in diagnosis/interpretation via Key Points in each chapter.