How Tobacco Smoke Causes Disease
How Tobacco Smoke Causes Disease

Author: United States. Public Health Service. Office of the Surgeon General

Publisher:

Published: 2010

Total Pages: 728

ISBN-13:

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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Preventing Tobacco Use Among Youth and Young Adults
Preventing Tobacco Use Among Youth and Young Adults

Author:

Publisher:

Published: 2012

Total Pages: 22

ISBN-13:

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This booklet for schools, medical personnel, and parents contains highlights from the 2012 Surgeon General's report on tobacco use among youth and teens (ages 12 through 17) and young adults (ages 18 through 25). The report details the causes and the consequences of tobacco use among youth and young adults by focusing on the social, environmental, advertising, and marketing influences that encourage youth and young adults to initiate and sustain tobacco use. This is the first time tobacco data on young adults as a discrete population have been explored in detail. The report also highlights successful strategies to prevent young people from using tobacco.

Nicotine Psychopharmacology
Nicotine Psychopharmacology

Author: Jack E. Henningfield

Publisher: Springer Science & Business Media

Published: 2009-02-01

Total Pages: 545

ISBN-13: 3540692487

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The fact that tobacco ingestion can affect how people feel and think has been known for millennia, placing the plant among those used spiritually, honori?cally, and habitually (Corti 1931; Wilbert 1987). However, the conclusion that nicotine - counted for many of these psychopharmacological effects did not emerge until the nineteenth century (Langley 1905). This was elegantly described by Lewin in 1931 as follows: “The decisive factor in the effects of tobacco, desired or undesired, is nicotine. . . ”(Lewin 1998). The use of nicotine as a pharmacological probe to und- stand physiological functioning at the dawn of the twentieth century was a landmark in the birth of modern neuropharmacology (Limbird 2004; Halliwell 2007), and led the pioneering researcher John Langley to conclude that there must exist some “- ceptive substance” to explain the diverse actions of various substances, including nicotine, when applied to muscle tissue (Langley 1905). Research on tobacco and nicotine progressed throughout the twentieth century, but much of this was from a general pharmacological and toxicological rather than a psychopharmacological perspective (Larson et al. 1961). There was some attention to the effects related to addiction, such as euphoria (Johnston 1941), tolerance (Lewin 1931), and withdrawal (Finnegan et al. 1945), but outside of research supported by the tobacco industry, addiction and psychopharmacology were not major foci for research (Slade et al. 1995; Hurt and Robertson 1998; Henning?eld et al. 2006; Henning?eld and Hartel 1999; Larson et al. 1961).

Combating Tobacco Use in Military and Veteran Populations
Combating Tobacco Use in Military and Veteran Populations

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2009-10-21

Total Pages: 381

ISBN-13: 0309146844

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The health and economic costs of tobacco use in military and veteran populations are high. In 2007, the Department of Veterans Affairs (VA) and the Department of Defense (DoD) requested that the Institute of Medicine (IOM) make recommendations on how to reduce tobacco initiation and encourage cessation in both military and veteran populations. In its 2009 report, Combating Tobacco in Military and Veteran Populations, the authoring committee concludes that to prevent tobacco initiation and encourage cessation, both DoD and VA should implement comprehensive tobacco-control programs.

Nicotine
Nicotine

Author: Gregor Hens

Publisher: Other Press, LLC

Published: 2017-01-10

Total Pages: 209

ISBN-13: 1590517938

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NAMED A BEST BOOK OF THE YEAR BY THE ECONOMIST By turns philosophical and darkly comic, an ex-smoker’s meditation on the nature and consequences of his nearly lifelong addiction. Written with the passion of an obsessive, Nicotine addresses a lifelong addiction, from the thrill of the first drag to the perennial last last cigarette. Reflecting on his experiences as a smoker from a young age, Gregor Hens investigates the irreversible effects of nicotine on thought and patterns of behavior. He extends the conversation with other smokers to meditations on Mark Twain and Italo Svevo, the nature of habit, and the validity of hypnosis. With comic insight and meticulous precision, Hens deconstructs every facet of dependency, offering a brilliant analysis of the psychopathology of addiction. This is a book about the physical, emotional, and psychological power of nicotine as not only an addictive drug, but also a gateway to memory, a long trail of streetlights in the rearview mirror of a smoker’s life. Cigarettes are sometimes a solace, sometimes a weakness, but always a witness and companion. This is a meditation, an ode, and a eulogy, one that will be passed hand-to-hand between close friends.

Analytical Determination of Nicotine and Related Compounds and their Metabolites
Analytical Determination of Nicotine and Related Compounds and their Metabolites

Author: J.W. Gorrod

Publisher: Elsevier

Published: 1999-11-02

Total Pages: 773

ISBN-13: 0080525512

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This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.

Negative Affective States and Cognitive Impairments in Nicotine Dependence
Negative Affective States and Cognitive Impairments in Nicotine Dependence

Author: F. Scott Hall

Publisher: Academic Press

Published: 2016-08-17

Total Pages: 364

ISBN-13: 0128026693

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Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative reinforcement mechanisms. Written and edited by leading investigators in addiction, affective, genetic, and cognitive research, it provides researchers and advanced students with an overview of the clinical bases of these effects, allowing them to fully understand the various underlying dysfunctions that drive nicotine use in different individuals. In addition, this book examines animal models that researchers have utilized to investigate the biological bases of these dysfunctions. The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function. - Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcement - Examines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco use - Includes both clinical and preclinical perspectives - Includes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawal - Emphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics

Tobacco and Health
Tobacco and Health

Author: K. Slama

Publisher: Springer Science & Business Media

Published: 1995

Total Pages: 1080

ISBN-13: 9780306451119

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Over 1,100 delegates from a hundred countries attended the 9th World Conference onTobaccoandHealth. Afterfivedaysofdebate, severalimportantresolutionswereadopted unanimously and will be landmarks in the fight against tobacco. This great success is due to three facts which emerged from the discussions: 1. Itappears clearlynowthattherisksassociated withtobaccoaremuchgreaterthan previously assumed. Out of two regular smokers, one will die from a tobacco­ related disease. 2. Reducing tobacco consumption can be achieved but the data collected in several countriesshowthatitrequiresaglobalstrategy.Thisstrategywasmuchdebatedduring theconference. Theresolutionsadoptedemphasizetheagreementofthedelegateson themainpoints. Actionto fight thegrowingepidemicoftobacco-attributabledisease and death involves convincing the general public, the medical community and decision-makers ofthe need to act for tobacco control. The most efficient tools for helping individuals never to start or successfully to stop using tobacco should be developed; effective tobacco control endeavors are required to counteractthe actions ofthe powerful and influential tobacco manufacturers. With the help and under the aegis ofWHO, DICC, IUATLD, ISFC, IOCD, and IUHPE, an international alliance for health and against tobacco shouldunite all those who are engaged in this fight.

Tobacco or Health?
Tobacco or Health?

Author: Knut-Olaf Haustein

Publisher: Springer Science & Business Media

Published: 2013-03-14

Total Pages: 462

ISBN-13: 3662052563

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"Science tends to generalize, and generaliza tions mean simplifications . . . . And generaliza tions are also more satisfying to the mind than details. Of course, details and generalizations must be in proper balance: Generalizations can be reached only from details, while it is the generalization which gives value and interest to the detail:' . . . (A. Szent-Gyorgy, Science 1964) The first edition of this book, published in German as Tabak abhiingigkeit in 2001, was prompted by the fact that no single volume was available in Germany or elsewhere summarising the adverse repercussions of cigarette smoking on human health. As far as my own research was able to ascertain, the last comprehensive work dealing with this subject was writ ten in Germany by the Dresden internist, F. Lickint, whose Tabak und Organismus was published in 1939 by the Hip pokrates-Verlag. All subsequent monographs in this field have tended to focus on detailed aspects, and there has been no shortage of publications on subjects such as how smokers can quit smoking, healthy eating for smokers etc. Friends and colleagues abroad have urged me to prepare an English language version of Tabakabhiingigkeit. In gladly complying with this suggestion, I have intentionally prepared an up dated and slightly enlarged new edition, taking account of the rapidly proliferating literature on the subject up to the start of 2002. The harmful sequelae of smoking are played down by politicians in many industrialised countries, including Ger many.