Engineering of Halogenases towards Synthetic Applications
Engineering of Halogenases towards Synthetic Applications

Author: Hannah Minges

Publisher: Springer

Published: 2017-05-11

Total Pages: 123

ISBN-13: 3658184108

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Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature’s toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place.

Flavin-Dependent Enzymes: Mechanisms, Structures and Applications
Flavin-Dependent Enzymes: Mechanisms, Structures and Applications

Author:

Publisher: Academic Press

Published: 2020-09-21

Total Pages: 568

ISBN-13: 012820138X

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The Enzymes, Volume 47, highlights new advances in the field, with this new volume presenting interesting chapters on The Multipurpose Family of Oxidases, Vanillyl alcohol oxidase, Choline oxidases, Aryl alcohol oxidase, D- and L-amino acid oxidases, Sugar oxidases, Phenolic Compounds hydroxylases, Baeyer-Villiger Monooxygenases, Flavin-dependent halogenases, Flavin-dependent dehalogenases, Styrene Monooxygenases, Bacterial luciferases, Cellobiose Dehydrogenases, Prenylated flavoenzymes, Ene-reductases, Flavoenzymes in Biocatalysis. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series

Flavin-based Catalysis
Flavin-based Catalysis

Author: Radek Cibulka

Publisher: Wiley-VCH

Published: 2021-09-07

Total Pages: 300

ISBN-13: 9783527348343

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The book gives a unique overview of this rapidly developing research field, presenting structures and properties of flavin derivatives as well as their proven application as bioinspired catalysts in various organocatalytic, biocatalytic, and photocatalytic reactions.

Natural Product Biosynthesis
Natural Product Biosynthesis

Author: Christopher T. Walsh

Publisher: Royal Society of Chemistry

Published: 2017-04-28

Total Pages: 787

ISBN-13: 1788010760

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This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.

Catalytic Aerobic Oxidations
Catalytic Aerobic Oxidations

Author: Esteban Mejía

Publisher: Royal Society of Chemistry

Published: 2020-07-14

Total Pages: 349

ISBN-13: 1839160349

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Oxidation reactions are an important chemical transformation in both academia and industry. Among the major advances in the field has been the development of catalytic processes, which are not only selective and efficient, but also allow the replacement of common stoichiometric oxidants with molecular oxygen, ideally from air at atmospheric pressure. This results in processes with higher atom efficiency, where water is the only side product in line with the principles of green chemistry. Focusing on the use of molecular oxygen as the terminal oxidant, this book covers recent advances in both heterogeneous and homogeneous systems, with and without metals and on the “taming” of the highly reactive oxygen gas by use of micro-flow reactors and membranes. A useful reference for industrial and academic chemists working on oxidation processes, as well as green chemists.

Synthetic Biology and Metabolic Engineering in Plants and Microbes Part A: Metabolism in Microbes
Synthetic Biology and Metabolic Engineering in Plants and Microbes Part A: Metabolism in Microbes

Author:

Publisher: Academic Press

Published: 2016-07-11

Total Pages: 428

ISBN-13: 0128046163

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Synthetic Biology and Metabolic Engineering in Plants and Microbes: Part A, the new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods, synthetic biology, and metabolic engineering in plants and microbes, and includes sections on such topics as the uses of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Contains two volumes covering research methods in synthetic biology and metabolic engineering in plants and microbes - Presents sections on such topics as the uses of integrases in microbial engineering, biosynthesis, and engineering of tryptophan derived metabolites, regulation and discovery of fungal natural products, and elucidation and localization of plant pathways

Modern Biocatalysis
Modern Biocatalysis

Author: Gavin Williams

Publisher: Royal Society of Chemistry

Published: 2018-05-31

Total Pages: 594

ISBN-13: 1788014537

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The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Amino Acids, Peptides and Proteins
Amino Acids, Peptides and Proteins

Author: Maxim Ryadnov

Publisher: Royal Society of Chemistry

Published: 2020-12-07

Total Pages: 189

ISBN-13: 1788017005

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Amino Acids, Peptides and Proteins is a broad ranging title comprising comprehensive and critical reviews of significant developments at the biology and chemistry interface. Compiled by leading researchers in their subject, this volume incorporates current trends and emerging areas in topics ranging from enzymatic halogenation, unnatural amino acids in peptide and protein chemistry and detection of protein post-translational modifications by mass spectrometry. Appealing broadly to researchers in academia and industry, it will be of great benefit to any researcher wanting a succinct reference in this field and looking at the future.

Biocatalysis for the Pharmaceutical Industry
Biocatalysis for the Pharmaceutical Industry

Author: Junhua (Alex) Tao

Publisher: John Wiley & Sons

Published: 2009-07-23

Total Pages: 250

ISBN-13: 0470823151

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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.