Neuroprotection in Autism, Schizophrenia and Alzheimer's disease
Neuroprotection in Autism, Schizophrenia and Alzheimer's disease

Author: Illana Gozes

Publisher: Academic Press

Published: 2019-10-16

Total Pages: 322

ISBN-13: 0128140380

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Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer's disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. - Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders - Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders - Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry

Neuroprotection in Alzheimer's Disease
Neuroprotection in Alzheimer's Disease

Author: Illana Gozes

Publisher: Academic Press

Published: 2016-12-30

Total Pages: 344

ISBN-13: 0128037121

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Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics. - Comprehensive reference detailing neuroprotection in Alzheimer's Disease, with details on nerve cell protection and new advances in disease management - Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development - Edited by one of the leading researchers in Alzheimer's Disease

Periodontitis
Periodontitis

Author: Julien Santi-Rocca

Publisher: Springer Nature

Published: 2022-05-25

Total Pages: 400

ISBN-13: 3030968812

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Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book “Periodontitis: Advances in Experimental Research” includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book “Periodontitis: Advances in Experimental Research” is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers)

Molecular Aspects of Neurodegeneration and Neuroprotection
Molecular Aspects of Neurodegeneration and Neuroprotection

Author: Akhlaq A. Farooqui

Publisher: Bentham Science Publishers

Published: 2011-01-26

Total Pages: 156

ISBN-13: 1608050920

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"Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For example, in Alzheimer disease, neuronal degeneration occu"

Protein Carbonylation
Protein Carbonylation

Author: Joaquim Ros

Publisher: John Wiley & Sons

Published: 2017-06-26

Total Pages: 416

ISBN-13: 1119074916

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Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification of carbonylated proteins and the sites where these modifications occur. The scientific community will benefit from these reviews since they deal with specific, detailed technical approaches to study formation and detection of protein carbonyls. Moreover, the biological impact of such modifications in metabolic, physiologic and structural functions and, how these alterations can help understanding the downstream effects on cell function are discussed. Oxidative stress occurs in all living organisms and affects proteins and other macromolecules: Protein carbonylation is a measure of oxidative stress in biological systems Mass spectrometry, fluorescent labelling, antibody based detection, biotinylated protein selection and other methods for detecting protein carbonyls and modification sites in proteins are described Aging, neurodegenerative diseases, obstructive pulmonary diseases, malaria, cigarette smoke, adipose tissue and its relationship with protein carbonylation Direct oxidation, glycoxidation and modifications by lipid peroxidation products as protein carbonylation pathways Emerging methods for characterizing carbonylated protein networks and affected metabolic pathways

Challenging Psychiatry’s Reliance on the Disease Model
Challenging Psychiatry’s Reliance on the Disease Model

Author: Digby Tantam

Publisher: Taylor & Francis

Published: 2024-08-22

Total Pages: 236

ISBN-13: 1040110436

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This volume critiques and challenges the use and promotion of the disease model in psychiatry, arguing that its misconceived approach prevents the preferred disablement model from becoming the default method to understand mental health conditions, including schizophrenia. Featuring first-hand experiences as well as qualitative and quantitative findings, the book posits that mental illnesses are an expression of disablement, not disease, and that the alternative disablement approach (already being applied in the psychiatry of neurodevelopmental disorders but applicable to mental illness, too) allows for greater dignity and autonomy for the patient, collaboration between medical professionals, a replacement of categorical approaches with more appropriate dimensional ones, and a liberation from the restrictive idea of a ‘cure’. The initial chapters of the book summarize the now overwhelming evidence that the disease model is flawed, as is the simplistic materialism that psychiatry has built around the concept of the brain as a kind of standalone biological computer. The later chapters consider the currently existent alternatives to the disease model and put forward the evidence for a psychiatry based on the person, as described by the philosopher Heidegger among others. This volume will appeal to researchers, scholars, and postgraduate students in clinical psychiatry, mental health research, and psychotherapy. Psychologists and clinicians active in research or teaching in mental health will also benefit from this volume.

Understanding PTMs in Neurodegenerative Diseases
Understanding PTMs in Neurodegenerative Diseases

Author: Victor Corasolla Carregari

Publisher: Springer Nature

Published: 2022-08-27

Total Pages: 150

ISBN-13: 3031054601

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This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs.

Marine Anti-inflammatory Agents 2020
Marine Anti-inflammatory Agents 2020

Author: Donatella Degl’Innocenti

Publisher: MDPI

Published: 2021-05-18

Total Pages: 112

ISBN-13: 3036507884

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This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.

Handbook of Research on Critical Issues in Special Education for School Rehabilitation Practices
Handbook of Research on Critical Issues in Special Education for School Rehabilitation Practices

Author: Singh, Ajay

Publisher: IGI Global

Published: 2021-04-23

Total Pages: 590

ISBN-13: 1799876322

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Rehabilitation professionals working with students with disabilities and the families of those students face unique challenges in providing inclusive services to special education student populations. There needs to be a focus on adaptive teaching methods that provide quality experience for students with varying disabilities to promote student success and inclusivity. Critical issues within these practices span autism, diverse students, gifted education, learning disabilities, behavioral and emotional disorders, and more. With having many different types of students with vastly different situations, it is important for rehabilitation professionals to understand the best practices and learning systems for special education students who have a wide range of needs and challenges. The Handbook of Research on Critical Issues in Special Education for School Rehabilitation Practices focuses on the issues and challenges rehabilitation professionals face in special education and how they can provide inclusive and effective services to diverse student populations. This book highlights topics such as culturally responsive teacher preparation, artificial intelligence in the classroom, universal design, inclusive development, and school rehabilitation and explores the effects these newfound practices in education have on various types of students with disabilities. This book is essential for special education teachers, administrators, counselors, practitioners, researchers, academicians, and students interested in the new methods, theories, and solutions for the best practices in inclusive and effective special education.