This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals, and in the rodents which are commonly employed in carcinogenesis studies in the laboratory.
This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals. and in the rodents which are commonly employed in carcinogenesis studies in the laboratory.
The International Life Sciences Institute (ILSI) was creat ed to promote cooperative efforts toward solving critical health and safety questions involving foods, drugs, cosmet ics, chemicals, and other aspects of the environment. The Officers and Trustees believe that questions regarding health and safety are best resolved when government and industry rely on scientific investigations, analyses, and re views by independent experts. Further, the scientific aspects of an issue should be examined and discussed on an international basis, separate from the political concerns of individual companies. ILSI is pleased to sponsor this set of monographs on the pathology of laboratory animals. This project will be use ful in improving the scientific basis for the application of pathologic techniques to health and safety evaluation of substances in our environment. The world wide distribu tion of the authors, editors, and Editorial Board who are creating these monographs strengthens the expectation that international communication and cooperation will al so be strengthened.
"This Monograph brings together within one cover the current knowledge about tumors of the nasal passages in man, in domestic and nondomestic animals, and in the rodents which are commonly employed in carcinogenesis studies in the laboratory."--Provided by publisher.
The series Pathology of Tumours in Laboratory Animals was initiated by the International Agency for Research on Cancer 25 years ago, to provide experimental pathologists with a comprehensive, coherent source of reference information, for use in chronic toxicology research. The first edition of the volume describing tumors of the mouse was issued in 1979. Since then many papers describing new models, new methods of induction, immunohistochemical methods, or important new details of old models have been published and efforts have been made to incorporate these data wherever possible. Each chapter deals with tumors of a particular organ or system and describes all neoplasms that have been reported to occur in the organ concerned, using the terminology proposed by WHO for human tumors. The structure adopted for each chapter in the first edition (normal structure of the organ in question, classification, morphology and histology of tumors, incidence of spontaneous tumors, methods of inductions, comparative aspects, illustrations and references) is retained in the new edition. Separate chapters are included in the second edition of this volume on tumors of the nasal cavities and tumors of the salivary and lacrimal glands; in the first edition these were described in one chapter. Likewise, the chapter on tumors of hematopoietic organs is now divided into two independent chapters, one on tumors of the lymphohematopoietic tissue and the other describing histolytic sarcoma. A brief chapter on gallbladder tumors has been added.
Of the interaction and relationship of both systems is chal In this volume, aspects of neoplastic spread, already elu cidated in Volumes I-IV of this series, are considered lenging indeed. against a broad biological background. The mammalian The volume also reviews environmental oncology and species-specific aspects of environmental chain reactions. It orders constituting the logical framework for man as focal point of a comparative oncology are reviewed. Selected is apparent that the environment plays a significant role in examples of neoplastic progression in various taxonomic the development of neoplasms. Neoplasms among the spe units are provided, beginning with the opposite pole of ci es have become much more common as a result of man's taxonomic development, the vascular plants, where no impact on the environment. The latter chapters present a metastatis of malignant neoplasms occur. Among in brief review of geologic and technologic and cuItural vertebrates, vertebrates, and vascular plants, Iining mem changes, and the implications of species-specific cancer pro branes (epithelia) exhibit the highest degree of comparabil gression. The remainder of this section outlines a number of ity. Metastases also occur, but more rarely, in invertebrates; selected chain reactions leading to neoplastic development and are discussed as they are found in the nonmammalian in certain members of these chains. A discussion of the vertebrates: in fish, amphibians, reptiles, and birds. Diseases storage of chemical carcinogens in plants and their interac ofthe leukemia (Ieucosis)-Iymphoma complex are present in tion with other causes of neoplastic growth is also included.
This book contains comprehensive information on the morphology of tumors in the lungs, liver, pancreas, kidneys, and disperse neuroendocrine system of man and the most commonly used laboratory rodents. It serves as an indispensable reference for cancer researchers, diagnostic pathologists, and readers who are interested in the comparative as-pects of tumor pathology and car-cinogenesis.