NAS Colloquium Links Between Recombination and Replication
Author: Proceedings of the National Academy of Sciences (
Publisher:
Published: 2002
Total Pages:
ISBN-13:
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Author: Proceedings of the National Academy of Sciences (
Publisher:
Published: 2002
Total Pages:
ISBN-13:
DOWNLOAD EBOOKAuthor: Proceedings of the National Academy of Sciences
Publisher: National Academies Press
Published: 2002-09-18
Total Pages: 303
ISBN-13: 030907424X
DOWNLOAD EBOOKThere has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.
Author:
Publisher:
Published: 2000
Total Pages: 303
ISBN-13:
DOWNLOAD EBOOKAuthor: Samuel Karlin
Publisher: National Academies Press
Published: 2005-09-28
Total Pages: 59
ISBN-13: 0309181984
DOWNLOAD EBOOKAuthor: National Academy of Sciences (U.S.)
Publisher:
Published: 2001
Total Pages: 1328
ISBN-13:
DOWNLOAD EBOOKAuthor: Aline V. Grigorian
Publisher:
Published: 2002
Total Pages: 268
ISBN-13:
DOWNLOAD EBOOKAuthor: National Academy of Sciences (U.S.)
Publisher:
Published: 2000
Total Pages: 372
ISBN-13:
DOWNLOAD EBOOKAuthor: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Published: 2016-08-28
Total Pages: 231
ISBN-13: 0309437873
DOWNLOAD EBOOKResearch on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Author: James Alan Shapiro
Publisher: Pearson Education
Published: 2011
Total Pages: 273
ISBN-13: 0132780933
DOWNLOAD EBOOKThis book proposes an important new paradigm for understanding biological evolution. Shapiro demonstrates why traditional views of evolution are inadequate to explain the latest evidence, and presents an alternative. His information- and systems-based approach integrates advances in symbiogenesis, epigenetics, and saltationism, and points toward an emerging synthesis of physical, information, and biological sciences.
Author:
Publisher: National Academies Press
Published: 2005
Total Pages: 59
ISBN-13: 0309100291
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