Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles
Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles

Author: Huilin Ye

Publisher: Morgan & Claypool Publishers

Published: 2020-01-02

Total Pages: 112

ISBN-13: 1643277928

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Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow.

Multiscale Modeling of Particle Interactions
Multiscale Modeling of Particle Interactions

Author: Michael King

Publisher: John Wiley & Sons

Published: 2010-03-30

Total Pages: 398

ISBN-13: 047057982X

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Discover how the latest computational tools are building our understanding of particle interactions and leading to new applications With this book as their guide, readers will gain a new appreciation of the critical role that particle interactions play in advancing research and developing new applications in the biological sciences, chemical engineering, toxicology, medicine, and manufacturing technology The book explores particles ranging in size from cations to whole cells to tissues and processed materials. A focus on recreating complex, real-world dynamical systems helps readers gain a deeper understanding of cell and tissue mechanics, theoretical aspects of multiscale modeling, and the latest applications in biology and nanotechnology. Following an introductory chapter, Multiscale Modeling of Particle Interactions is divided into two parts: Part I, Applications in Nanotechnology, covers: Multiscale modeling of nanoscale aggregation phenomena: applications in semiconductor materials processing Multiscale modeling of rare events in self-assembled systems Continuum description of atomic sheets Coulombic dragging and mechanical propelling of molecules in nanofluidic systems Molecular dynamics modeling of nanodroplets and nanoparticles Modeling the interactions between compliant microcapsules and patterned surfaces Part II, Applications in Biology, covers: Coarse-grained and multiscale simulations of lipid bilayers Stochastic approach to biochemical kinetics In silico modeling of angiogenesis at multiple scales Large-scale simulation of blood flow in microvessels Molecular to multicellular deformation during adhesion of immune cells under flow Each article was contributed by one or more leading experts and pioneers in the field. All readers, from chemists and biologists to engineers and students, will gain new insights into how the latest tools in computational science can improve our understanding of particle interactions and support the development of novel applications across the broad spectrum of disciplines in biology and nanotechnology.

Handbook of Harnessing Biomaterials in Nanomedicine
Handbook of Harnessing Biomaterials in Nanomedicine

Author: Dan Peer

Publisher: CRC Press

Published: 2021-01-25

Total Pages: 542

ISBN-13: 1000284182

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Nanomedicine has emerged as a novel field in medicine integrating nano-scale technologies with materials sciences, chemistry and biology. The medical application of nanotechnology has the potential to revolutionize diagnosis and therapy and bring this new field from a notion into reality while impacting the lives of millions around the world. This second edition compiles and details the latest cutting-edge research in science and medicine from the interdisciplinary standpoint who are currently revolutionizing drug delivery techniques through the development of nanomedicines. Edited by Dan Peer, a prominent bio-nanotechnologiest, this book will attract anyone involved materials sciences, chemistry, biology and medicine that would like to design applications in the medical field of nanotechnology towards cancer therapy, inflammation, viral infection, imaging and toxicity.

Nano and Cell Mechanics
Nano and Cell Mechanics

Author: Horacio D. Espinosa

Publisher: John Wiley & Sons

Published: 2012-12-12

Total Pages: 519

ISBN-13: 111848259X

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Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book. Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. Key features: • Provides an overview of recent advances in nano and cell mechanics. • Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena. • Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. • Presents multiscale-multiphysics modeling and experimentation techniques. • Examines applications in materials, manufacturing, electronics, medicine and healthcare. Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.

Nonlinear Dynamics
Nonlinear Dynamics

Author: Marc R Roussel

Publisher: Morgan & Claypool Publishers

Published: 2019-05-01

Total Pages: 190

ISBN-13: 1643274643

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This book uses a hands-on approach to nonlinear dynamics using commonly available software, including the free dynamical systems software Xppaut, Matlab (or its free cousin, Octave) and the Maple symbolic algebra system. Detailed instructions for various common procedures, including bifurcation analysis using the version of AUTO embedded in Xppaut, are provided. This book also provides a survey that can be taught in a single academic term covering a greater variety of dynamical systems (discrete versus continuous time, finite versus infinite-dimensional, dissipative versus conservative) than is normally seen in introductory texts. Numerical computation and linear stability analysis are used as unifying themes throughout the book. Despite the emphasis on computer calculations, theory is not neglected, and fundamental concepts from the field of nonlinear dynamics such as solution maps and invariant manifolds are presented.

Multiscale Modeling in Biomechanics and Mechanobiology
Multiscale Modeling in Biomechanics and Mechanobiology

Author: Suvranu De

Publisher: Springer

Published: 2014-10-10

Total Pages: 287

ISBN-13: 1447165993

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Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Advances in Computational Fluid-Structure Interaction and Flow Simulation
Advances in Computational Fluid-Structure Interaction and Flow Simulation

Author: Yuri Bazilevs

Publisher: Birkhäuser

Published: 2016-10-04

Total Pages: 487

ISBN-13: 3319408275

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This contributed volume celebrates the work of Tayfun E. Tezduyar on the occasion of his 60th birthday. The articles it contains were born out of the Advances in Computational Fluid-Structure Interaction and Flow Simulation (AFSI 2014) conference, also dedicated to Prof. Tezduyar and held at Waseda University in Tokyo, Japan on March 19-21, 2014. The contributing authors represent a group of international experts in the field who discuss recent trends and new directions in computational fluid dynamics (CFD) and fluid-structure interaction (FSI). Organized into seven distinct parts arranged by thematic topics, the papers included cover basic methods and applications of CFD, flows with moving boundaries and interfaces, phase-field modeling, computer science and high-performance computing (HPC) aspects of flow simulation, mathematical methods, biomedical applications, and FSI. Researchers, practitioners, and advanced graduate students working on CFD, FSI, and related topics will find this collection to be a definitive and valuable resource.

Multiscale Models in Mechano and Tumor Biology
Multiscale Models in Mechano and Tumor Biology

Author: Alf Gerisch

Publisher: Springer

Published: 2018-03-16

Total Pages: 205

ISBN-13: 3319733710

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This book presents and discusses the state of the art and future perspectives in mathematical modeling and homogenization techniques with the focus on addressing key physiological issues in the context of multiphase healthy and malignant biological materials. The highly interdisciplinary content brings together contributions from scientists with complementary areas of expertise, such as pure and applied mathematicians, engineers, and biophysicists. The book also features the lecture notes from a half-day introductory course on asymptotic homogenization. These notes are suitable for undergraduate mathematics or physics students, while the other chapters are aimed at graduate students and researchers.

Computational Approaches in Biomedical Nano-Engineering
Computational Approaches in Biomedical Nano-Engineering

Author: Ayesha Sohail

Publisher: John Wiley & Sons

Published: 2018-08-31

Total Pages: 296

ISBN-13: 3527344748

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This book comprehensively and systematically treats modern understanding of the Nano-Bio-Technology and its therapeutic applications. The contents range from the nanomedicine, imaging, targeted therapeutic applications, experimental results along with modelling approaches. It will provide the readers with fundamentals on computational and modelling aspects of advanced nano-materials and nano-technology specifically in the field of biomedicine, and also provide the readers with inspirations for new development of diagnostic imaging and targeted therapeutic applications.

Nanomedicine
Nanomedicine

Author: Mingjun Zhang

Publisher: CRC Press

Published: 2019-05-08

Total Pages: 220

ISBN-13: 0429533667

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This book offers a fundamental and comprehensive overview of nanomedicine from a systems engineering perspective, making it the first book in the field of quantitative nanomedicine based on systems theory. The book starts by introducing the concept of nanomedicine and provides basic mathematical modeling techniques that can be used to model nanoscale biomedical and biological systems. It then demonstrates how this idea can be used to model and analyze the central dogma of molecular biology, tumor growth and the immune system. Broad applications of the idea are further illustrated by Bayesian networks, multiscale and multiparadigm modeling and AFM engineering.