Design and Analysis of Long-term Ecological Monitoring Studies

Design and Analysis of Long-term Ecological Monitoring Studies

Author: Robert A. Gitzen

Publisher: Cambridge University Press

Published: 2012-06-07

Total Pages: 779

ISBN-13: 1139510193

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To provide useful and meaningful information, long-term ecological programs need to implement solid and efficient statistical approaches for collecting and analyzing data. This volume provides rigorous guidance on quantitative issues in monitoring, with contributions from world experts in the field. These experts have extensive experience in teaching fundamental and advanced ideas and methods to natural resource managers, scientists and students. The chapters present a range of tools and approaches, including detailed coverage of variance component estimation and quantitative selection among alternative designs; spatially balanced sampling; sampling strategies integrating design- and model-based approaches; and advanced analytical approaches such as hierarchical and structural equation modelling. Making these tools more accessible to ecologists and other monitoring practitioners across numerous disciplines, this is a valuable resource for any professional whose work deals with ecological monitoring. Supplementary example software code is available online at www.cambridge.org/9780521191548.


Nonclinical Study Contracting and Monitoring

Nonclinical Study Contracting and Monitoring

Author: William F. Salminen

Publisher: Academic Press

Published: 2012-12-31

Total Pages: 263

ISBN-13: 0123978319

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Nonclinical Study Contracting and Monitoring: A Practical Guide offers a systematic and straightforward handbook for obtaining high quality preclinical Good Laboratory Practice (GLP) studies. This book is full of real-world examples, processes, procedures, useful templates, checklists and sample reports to provide readers with a better understanding of exactly what happens during all stages of a GLP study and the critical aspects of GLP study design and conduct. Designed for both the novice and experienced scientist, this book covers the GLP regulations and how they impact preclinical studies, the differences between GLP, non-GLP and peer-reviewed studies, preclinical GLP study design, laboratory selection, contracts and business ethics, how to obtain test material for the study, animal sourcing and release for study, preparation of a draft report and much more. By illustrating the overall big picture and tying it together with the individual steps, this book is an essential resource to help scientists ensure a high quality GLP study that passes both scientific and regulatory scrutiny. - Includes both the "big picture" look at complex processes, such as contracting toxicology and safety studies with CROs, as well as a detailed account of each individual step - Contains several real world examples of problems in preclinical studies to provide you with an idea of the types of challenges that are routinely encountered and how this book can help you avoid these issues - Provides monitoring checklists through the book that will help you comply with each GLP requirement and maintain compliance throughout the entire process - Both entry level and experienced scientists involved in nonclinical toxicology study monitoring will benefit from the ideas, examples, discussions and strategies presented throughout this book


Data Monitoring in Clinical Trials

Data Monitoring in Clinical Trials

Author: David L. DeMets

Publisher: Springer Science & Business Media

Published: 2006-06-22

Total Pages: 389

ISBN-13: 0387301070

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From the authors of "Fundamentals of Clinical Trials" which has sold over 15,000 copies world wide since its publication in 1998. No competition yet as the text does not focus on how to do clinical trials but on very specific situations that can be encountered during the process.


Infrasound Monitoring for Atmospheric Studies

Infrasound Monitoring for Atmospheric Studies

Author: Alexis Le Pichon

Publisher: Springer Science & Business Media

Published: 2010-01-19

Total Pages: 739

ISBN-13: 1402095082

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The use of infrasound to monitor the atmosphere has, like infrasound itself, gone largely unheard of through the years. But it has many applications, and it is about time that a book is being devoted to this fascinating subject. Our own involvement with infrasound occurred as graduate students of Prof. William Donn, who had established an infrasound array at the Lamont-Doherty Geological Observatory (now the Lamont-Doherty Earth Observatory) of Columbia University. It was a natural outgrowth of another major activity at Lamont, using seismic waves to explore the Earth’s interior. Both the atmosphere and the solid Earth feature velocity (seismic or acoustic) gradients in the vertical which act to refract the respective waves. The refraction in turn allows one to calculate the respective background structure in these mediums, indirectly exploring locations that are hard to observe otherwise. Monitoring these signals also allows one to discover various phenomena, both natural and man-made (some of which have military applications).


Data Monitoring Committees in Clinical Trials

Data Monitoring Committees in Clinical Trials

Author: Susan S. Ellenberg

Publisher: John Wiley & Sons

Published: 2003-01-17

Total Pages: 208

ISBN-13: 0470854154

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There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This growth has been brought about by increasing recognition of the value of such committees in safeguarding trial participants as well as protecting trial integrity and the validity of conclusions. This very timely book describes the operation of data monitoring committees, and provides an authoritative guide to their establishment, purpose and responsibilities. * Provides a practical overview of data monitoring in clinical trials. * Describes the purpose, responsibilities and operation of data monitoring committees. * Provides directly applicable advice for those managing and conducting clinical trials, and those serving on data monitoring committees. * Gives insight into clinical data monitoring to those sitting on regulatory and ethical committees. * Discusses issues pertinent to those working in clinical trials in both the US and Europe. The practical guidance provided by this book will be of use to professionals working in and/or managing clinical trials, in academic, government and industry settings, particularly medical statisticians, clinicians, trial co-ordinators, and those working in regulatory affairs and bioethics.


Responsible Research

Responsible Research

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2003-02-06

Total Pages: 313

ISBN-13: 0309084881

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When 18-year-old Jesse Gelsinger died in a gene transfer study at the University of Pennsylvania, the national spotlight focused on the procedures used to ensure research participants' safety and their capacity to safeguard the well-being of those who volunteer for research studies. Responsible Research outlines a three-pronged approach to ensure the protection of every participant through the establishment of effective Human Research Participant Protection Programs (HRPPPs). The approach includes: Improved research review processes, Recognition and integration of research participants' contributions to the system, and Vigilant maintenance of HRPPP performance. Issues addressed in the book include the need for in-depth, complimentary reviews of science, ethics, and conflict of interest reviews; desired qualifications for investigators and reviewers; the process of informed consent; federal and institutional oversight; and the role of accreditation. Recommendations for areas of key interest include suggestions for legislative approaches, compensation for research-related injury, and the refocusing of the mission of institutional review boards. Responsible Research will be important to anyone interested in the issues that are relevant to the practice of using human subjects as research participants, but especially so to policy makers, research administrators, investigators, and research sponsorsâ€"but also including volunteers who may agree to serve as research participants.


Social Monitoring for Public Health

Social Monitoring for Public Health

Author: Michael J. Paul

Publisher: Morgan & Claypool Publishers

Published: 2017-08-31

Total Pages: 188

ISBN-13: 1681736101

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Public health thrives on high-quality evidence, yet acquiring meaningful data on a population remains a central challenge of public health research and practice. Social monitoring, the analysis of social media and other user-generated web data, has brought advances in the way we leverage population data to understand health. Social media offers advantages over traditional data sources, including real-time data availability, ease of access, and reduced cost. Social media allows us to ask, and answer, questions we never thought possible. This book presents an overview of the progress on uses of social monitoring to study public health over the past decade. We explain available data sources, common methods, and survey research on social monitoring in a wide range of public health areas. Our examples come from topics such as disease surveillance, behavioral medicine, and mental health, among others. We explore the limitations and concerns of these methods. Our survey of this exciting new field of data-driven research lays out future research directions.


Advanced Materials and Techniques for Structural Monitoring, Analysis and Control

Advanced Materials and Techniques for Structural Monitoring, Analysis and Control

Author: Chun-Xu Qu

Publisher: Frontiers Media SA

Published: 2024-06-18

Total Pages: 187

ISBN-13: 2832550290

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Assessing the service status and maintaining the safety of existing structures are critical to the sustainable operations of various engineering and cross-industry, including civil infrastructures, railways and machinery. Static and dynamic structural characteristics play a key role in the global deterioration assessment of the structural performance, which has enabled structural monitoring and analysis technology to become an active focus in the engineering area. Meanwhile, structural control has been widely used in modern structural engineering. Structural control devices are implemented to enhance deteriorating structures and mitigate natural disasters. Through advanced structural control technology, the structural responses can be controlled. These structural control techniques include passive, active or semi-active reverse forces, which aim to modify structural stiffness, mass and damping with minimal control force. Structural control, monitoring and analysis complement each other, ensuring the safety of the structure to the greatest extent.