Molecular Mechanisms of MicroRNA Regulation in Breast Cancer Cells
Author: Irene Kathryn Guttilla
Publisher:
Published: 2010
Total Pages: 388
ISBN-13:
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MicroRNA Cancer Regulation
Author: Ulf Schmitz
Publisher: Springer Science & Business Media
Published: 2013-02-03
Total Pages: 352
ISBN-13: 9400755902
DOWNLOAD EBOOKThis edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.
MicroRNA in Development and in the Progression of Cancer
Author: Shree Ram Singh
Publisher: Springer Science & Business
Published: 2014-04-21
Total Pages: 410
ISBN-13: 1489980652
DOWNLOAD EBOOKmiRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
MicroRNAs in Cancer
Author: César López-Camarillo
Publisher: CRC Press
Published: 2013-02-22
Total Pages: 428
ISBN-13: 1466576766
DOWNLOAD EBOOKMicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.
MicroRNAs: Key Regulators of Oncogenesis
Author: Sadegh Babashah
Publisher: Springer
Published: 2014-07-08
Total Pages: 449
ISBN-13: 3319037250
DOWNLOAD EBOOKAberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.
Molecular Mechanisms of Triple Negative and Basal-like Breast Cancers
Author: Chika Nwachukwu
Publisher:
Published: 2010
Total Pages: 172
ISBN-13: 9781124197913
DOWNLOAD EBOOKFurthermore, differential expression of microRNAs in sporadic triple negative and basal-like tumors was examined using a microRNA expression array. Forty-four microRNAs were identified as down-regulated in basal-like tumors compared to luminal A tumors, and microRNA-29c, the most significantly down-regulated microRNA, was capable of regulating some phenotypes associated with basal-like tumors (e.g. cell invasion and drug resistance). microRNA-29c also regulates B-MYB levels and this regulation involves the B-MYB 3'UTR. Furthermore, microRNA-29c sensitizes cells to doxorubicin-induced killing through regulation of B-MYB, an oncogene over-expressed in basal-like tumors. This work represents the first study to functionally characterize the role of miRNAs in basal-like breast tumors, as well as identify B-MYB as a bonafide miR-29c target. My findings suggest that inhibition of B-MYB or over-expression of miR-29c may be clinically beneficial for patients with basal-like tumors.
Role of MicroRNAs in Cancers
Author: DKV Prasad
Publisher: Springer Nature
Published: 2022-06-07
Total Pages: 183
ISBN-13: 981169186X
DOWNLOAD EBOOKThis book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.
Micrornas In Development And Cancer
Author: Frank J Slack
Publisher: World Scientific
Published: 2010-10-20
Total Pages: 299
ISBN-13: 1908978473
DOWNLOAD EBOOKMicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer./a
MicroRNA
Author: Junjie Xiao
Publisher: Academic Press
Published: 2022-07-19
Total Pages: 655
ISBN-13: 0323885586
DOWNLOAD EBOOKMicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases. The book consists of eight parts, beginning with an introduction to microRNA and the current state of the field, followed by sections on biogenesis and maturation of microRNA, and methodology and bioinformatics, where chapters focus on isolation and detection techniques. Sections then move on to molecular mechanisms and gene regulation, considering topics such as transcriptional regulation and epigenetic regulation, as well as the role of microRNA as biomarkers. Additionally, microRNA and human disease and microRNA-based therapeutics are explored, focusing on a wide range of diseases such as cancer, age-related disease, cardiovascular disease, microRNA targeted therapy in hepatitis and therapeutic strategies for diabetes. The book concludes with a discussion on advances and future perspectives in microRNA investigation. Covers the topic of microRNA in detail, from foundational knowledge to clinical application Explores the physiological and pathological roles of microRNAs in various human diseases, including neurological, cardiovascular and age-related diseases Discusses future directions and challenges in the field Includes chapters on methodology and bioinformatics for microRNA research
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
Author: Bernd Nilius
Publisher: Springer
Published: 2016-09-21
Total Pages: 141
ISBN-13: 331943814X
DOWNLOAD EBOOKLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
