Modelling Degradation of Bioresorbable Polymeric Medical Devices

Modelling Degradation of Bioresorbable Polymeric Medical Devices

Author: J Pan

Publisher: Elsevier

Published: 2014-10-24

Total Pages: 271

ISBN-13: 1782420258

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The use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming. This book provides readers with a comprehensive review of modelling polymers and polymeric medical devices as an alternative to practical experiments. Chapters in part one provide readers with an overview of the fundamentals of biodegradation. Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers. This book is an essential guide to those concerned with replacing tests and experiments with modelling. - Provides a comprehensive mathematical framework for computer modelling of polymers and polymeric medical devices that can significantly reduce the number of experiments needed - Reviews the fundamental methods of modelling degradation, and applies these to particular materials including amorphous bioresorbable polyesters, semicrystalline biodegradable polyesters, and composite materials made of biodegradable polyesters and triclcium phosphates


Bioresorbable Polymers for Biomedical Applications

Bioresorbable Polymers for Biomedical Applications

Author: Giuseppe Perale

Publisher: Woodhead Publishing

Published: 2016-08-24

Total Pages: 630

ISBN-13: 0081002661

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Bioresorbable Polymers for Biomedical Applications: From Fundamentals to Translational Medicine provides readers with an overview of bioresorbable polymeric materials in the biomedical field. A useful resource for materials scientists in industry and academia, offering information on the fundamentals and considerations, synthesis and processing, and the clinical and R and D applications of bioresorbable polymers for biomedical applications. - Focuses on biomedical applications of bioresorbable polymers - Features a comprehensive range of topics including fundamentals, synthesis, processing, and applications - Provides balanced coverage of the field with contributions from academia and industry - Includes clinical and R and D applications of bioresorbable polymers for biomedical applications


Science and Principles of Biodegradable and Bioresorbable Medical Polymers

Science and Principles of Biodegradable and Bioresorbable Medical Polymers

Author: Xiang Cheng Zhang

Publisher: Woodhead Publishing

Published: 2016-09-22

Total Pages: 478

ISBN-13: 0081003935

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Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties provides a practical guide to the use of biodegradable and bioresorbable polymers for study, research, and applications within medicine. Fundamentals of the basic principles and science behind the use of biodegradable polymers in advanced research and in medical and pharmaceutical applications are presented, as are important new concepts and principles covering materials, properties, and computer modeling, providing the reader with useful tools that will aid their own research, product design, and development. Supported by practical application examples, the scope and contents of the book provide researchers with an important reference and knowledge-based educational and training aid on the basics and fundamentals of these important medical polymers. - Provides a practical guide to the fundamentals, synthesis, and processing of bioresorbable polymers in medicine - Contains comprehensive coverage of material properties, including unique insights into modeling degradation - Written by an eclectic mix of international authors with experience in academia and industry


A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites

A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites

Author: Ismael Moreno-Gomez

Publisher: Springer

Published: 2019-04-05

Total Pages: 361

ISBN-13: 3030049906

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This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation. Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.


Bioresorbable Polymers and their Composites

Bioresorbable Polymers and their Composites

Author: Deepak Verma

Publisher: Elsevier

Published: 2023-11-23

Total Pages: 538

ISBN-13: 0443189161

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Bioresorbable Polymers and their Composites: Characterization and Fundamental Processing for Pharmaceutical and Medical Device Development provides a holistic view of these unique materials and their usage in a range of biomedical applications. The book is evenly divided between fundamentals, processing methods and modeling approaches, and includes detailed coverage of a variety of applications, such as drug delivery, medical devices and wound healing. Key aspects including biocompatibility, biodegradability and toxicology are also thoroughly covered, enabling the reader to be fully informed when fabricating and utilizing their selected bioresorbable polymer. This book is an interdisciplinary and important reference for researchers in the fields of materials science, biomedical engineering, pharmaceutical science and regenerative medicine, as well as R&D groups in the development of medical devices. - Introduces the reader to various processing and modeling techniques for bioresorbable polymers, including electrospinning, molecular and finite element modeling - Covers a range of key bioresorbable composites, such as PCL, PLA/PLLA and PHA/PHB/PHBV - Explores a wide selection of biomedical applications of bioresorbable polymers, from tissue engineering and stents, to biosensors and medical devices/implants


Materials for Biomedical Engineering: Absorbable Polymers

Materials for Biomedical Engineering: Absorbable Polymers

Author: Alexandru Grumezescu

Publisher: Elsevier

Published: 2019-06-18

Total Pages: 457

ISBN-13: 0128184167

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Materials for Biomedical Engineering: Absorbable Polymers provides a detailed and comprehensive review of recent progress in absorbable biopolymers and their impact on biomedical engineering. The book's main focus lies in their classification, processing, properties and performance, biocompatibility, and their applications in tissue engineering, drug delivery, bone repair and regenerative medicine. The most up-to-date methods used to obtain such polymers and how to improve their properties is discussed in detail. This book provides readers with a comprehensive and updated review of the latest research in the field of absorbable polymers for biomedical applications. - Provides knowledge of the range of absorbable polymers currently available, enabling the reader to make optimal materials selection decisions - Presents detailed information on current and proposed applications of the latest developments - Includes a strong emphasis on chemistry and physico-chemical characterization of these materials and their application in biomedical engineering


Shape Memory Polymers for Biomedical Applications

Shape Memory Polymers for Biomedical Applications

Author: L Yahia

Publisher: Elsevier

Published: 2015-03-19

Total Pages: 325

ISBN-13: 0857097059

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Shape memory polymers (SMPs) are an emerging class of smart polymers which give scientists the ability to process the material into a permanent state and predefine a second temporary state which can be triggered by different stimuli. The changing chemistries of SMPs allows scientists to tailor important properties such as strength, stiffness, elasticity and expansion rate. Consequently SMPs are being increasingly used and developed for minimally invasive applications where the material can expand and develop post insertion. This book will provide readers with a comprehensive review of shape memory polymer technologies. Part 1 will discuss the fundamentals and mechanical aspects of SMPs. Chapters in part 2 will look at the range of technologies and materials available for scientific manipulation whilst the final set of chapters will review applications. - Reviews the fundamentals of shape memory polymers with chapters focussing on the basic principles of the materials - Comprehensive coverage of design and mechanical aspects of SMPs - Expert analysis of the range of technologies and materials available for scientific manipulation


Medical Modelling

Medical Modelling

Author: Richard Bibb

Publisher: Woodhead Publishing

Published: 2014-12-13

Total Pages: 517

ISBN-13: 1782423133

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Medical modelling and the principles of medical imaging, Computer Aided Design (CAD) and Rapid Prototyping (also known as Additive Manufacturing and 3D Printing) are important techniques relating to various disciplines - from biomaterials engineering to surgery. Building on the success of the first edition, Medical Modelling: The application of Advanced Design and Rapid Prototyping techniques in medicine provides readers with a revised edition of the original text, along with key information on innovative imaging techniques, Rapid Prototyping technologies and case studies.Following an overview of medical imaging for Rapid Prototyping, the book goes on to discuss working with medical scan data and techniques for Rapid Prototyping. In this second edition there is an extensive section of peer-reviewed case studies, describing the practical applications of advanced design technologies in surgical, prosthetic, orthotic, dental and research applications. - Covers the steps towards rapid prototyping, from conception (modelling) to manufacture (manufacture) - Includes a comprehensive case studies section on the practical application of computer-aided design (CAD) and rapid prototyping (RP) - Provides an insight into medical imaging for rapid prototyping and working with medical scan data


Materials and Devices for Bone Disorders

Materials and Devices for Bone Disorders

Author: Susmita Bose

Publisher: Academic Press

Published: 2016-11-03

Total Pages: 561

ISBN-13: 0128028033

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Materials for Bone Disorders is written by a cross-disciplinary team of research scientists, engineers, and clinicians and bridges the gap between materials science and bone disorders, providing integrated coverage of biomaterials and their applications. The bioceramics, biopolymers, composites, and metallic materials used in the treatment of bone disorders are introduced, as are their interactions with cells, biomolecules, and body tissues. The main types of bone disorder and disease are covered including osteoporosis, spinal injury, load bearing joint diseases, bone cancer, and forms of cranio-maxillofacial disorders. Bone disorders are common across all ages. Various forms of bone disorders can change the lifestyle of otherwise normal and healthy people. With the development of novel materials, many forms of bone disorders are becoming manageable, allowing people to lead a fairly normal life. Specific consideration is given to areas where recent advances are enabling new treatments, such as the use of resorbable ceramics in bone tissue engineering and drug delivery, newer polymer-based implants in load-bearing contexts, and engineering biomaterials surfaces including modifying surface chemistry. Ethical and regulatory issues are also explored. - Explores biomaterials for bone repair and related applications in orthopedics and dentistry in a clinical context - Introduces biomaterials applications in the context of specific diseases, bone disorders, and theraputic contexts - Includes input from a world-class team of research scientists, engineers, and clinicians - Covers the main types of bone disorder and disease including osteoporosis, spinal injury, load bearing joint diseases, bone cancer, and forms of cranio-maxillofacial disorders


Medical Devices

Medical Devices

Author: Seeram Ramakrishna

Publisher: Woodhead Publishing

Published: 2015-08-18

Total Pages: 253

ISBN-13: 0081002912

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Medical Devices and Regulations: Standards and Practices will shed light on the importance of regulations and standards among all stakeholders, bioengineering designers, biomaterial scientists and researchers to enable development of future medical devices. Based on the authors' practical experience, this book provides a concise, practical guide on key issues and processes in developing new medical devices to meet international regulatory requirements and standards. - Provides readers with a global perspective on medical device regulations - Concise and comprehensive information on how to design medical devices to ensure they meet regulations and standards - Includes a useful case study demonstrating the design and approval process