Mitochondrial Physiology and Vegetal Molecules
Mitochondrial Physiology and Vegetal Molecules

Author: Marcos Roberto de Oliveira

Publisher: Academic Press

Published: 2021-07-14

Total Pages: 808

ISBN-13: 0128215836

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Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area. This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others. Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle. - Contains detailed information on plant products and their effect on mitochondria - Proposes therapies and reviews mechanisms of absorption at the cellular level - Discusses the limited bioavailability of plant molecules/compounds in the human organism - Includes coverage of specific conditions such as Sports and affective disorders, among others - Presents the protective effects of plant products in mitochondrial health through all stages of life

Mitochondrial Intoxication
Mitochondrial Intoxication

Author: Marcos Roberto de Oliveira

Publisher: Elsevier

Published: 2022-11-30

Total Pages: 800

ISBN-13: 0323884636

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Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. - Features a wide range of toxicants and their effects on mitochondrial physiology - Covers molecular markers of mitochondrial intoxication - Includes case studies that illustrate the health impacts of toxicity upon mitochondria - Considers future directions regarding the study of mitochondrial intoxication

Molecular Nutrition and Mitochondria
Molecular Nutrition and Mitochondria

Author: Sergej M. Ostojic

Publisher: Academic Press

Published: 2022-10-20

Total Pages: 714

ISBN-13: 0323984525

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Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction. Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food. Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction. - Describes the fundamentals of mitochondria physiology and considers the methods used to evaluate mitochondrial imbalance in clinical practice - Provides broad biochemical and metabolic background on nutritional deficits found in mitochondrial dysfunction - Explores the prevention and treatment of various inherited and acquired disorders associated with mitochondrial dysfunction - Discusses the link between the dosage for each nutrient (nutritional vs. pharmacological) and the clinical effect - Features a dedicated section on whole-diet interventions and mitochondrial function

Mitochondrial Dysfunction and Nanotherapeutics
Mitochondrial Dysfunction and Nanotherapeutics

Author: Marcos Roberto de Oliveira

Publisher: Academic Press

Published: 2021-07-15

Total Pages: 602

ISBN-13: 0323886183

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Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. - Contains detailed information on mitochondrial dysfunction - Reviews our current understanding of the role of mitochondria in aging - Includes coverage of specific conditions, including sports and affective disorders, among others - Discusses mitochondria targeted delivery of therapeutic compounds

Plant Biochemistry
Plant Biochemistry

Author: Hans-Walter Heldt

Publisher: Academic Press

Published: 2005

Total Pages: 658

ISBN-13: 0120883910

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1 A Leaf Cell Consists of Several Metabolic Compartments 2 The Use of Energy from Sunlight by Photosynthesis is the Basis of Life on Earth 3 Photosynthesis is an Electron Transport Process 4 ATP is Generated by Photosynthesis 5 Mitochondria are the Power Station of the Cell 6 The Calvin Cycle Catalyzes Photosynthetic CO2 Assimilation 7 In the Photorespiratory Pathway Phosphoglycolate Formed by the Oxygenase Activity of RubisCo is Recycled 8 Photosynthesis Implies the Consumption of Water 9 Polysaccharides are Storage and Transport Forms of Carbohydrates Produced by Photosynthesis 10Nitrate Assimilation is Essential for the Synthesis of Organic Matter 11 Nitrogen Fixation Enables the Nitrogen in the Air to be Used for Plant Growth 12 Sulfate Assimilation Enables the Synthesis of Sulfur Containing Substances 13 Phloem Transport Distributes Photoassimilates to the Various Sites of Consumption and Storage 14 Products of Nitrate Assimilation are Deposited in Plants as Storage Proteins 15 Glycerolipids are Membrane Constituents and Function as Carbon Stores 16 Secondary Metabolites Fulfill Specific Ecological Functions in Plants 17 Large Diversity of Isoprenoids has Multiple Funtions in Plant Metabolism 18 Phenylpropanoids Comprise a Multitude of Plant Secondary Metabolites and Cell Wall Components 19 Multiple Signals Regulate the Growth and Development of Plant Organs and Enable Their Adaptation to Environmental Conditions 20 A Plant Cell has Three Different Genomes 21 Protein Biosynthesis Occurs at Different Sites of a Cell 22 Gene Technology Makes it Possible to Alter Plants to Meet Requirements of Agriculture, Nutrition, and Industry.

Ketogenic
Ketogenic

Author: Tim Noakes

Publisher: Elsevier

Published: 2023-06-22

Total Pages: 554

ISBN-13: 0128216239

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**Selected for Doody's Core Titles® 2024 in Nutrition** Ketogenic: The Science of Therapeutic Carbohydrate Restriction in Human Health presents the most up-to-date and evidence-based science and research available in the field of TCR, with the purpose of training medical and allied healthcare professionals on the effective therapeutic use of low-carbohydrate and ketogenic nutrition in clinical practice. This book explores the appropriate, safe, and effective use of TCR to improve patient outcomes in a broad range of chronic metabolic conditions and aims to promote health. Focused on lifestyle management, health support and the treatment of diseases rooted in poor nutrition, this book explores the role of food and lifestyle modification as medicine and is a valuable resource for nutritionists, dietitians and medical professionals who provide diet-related counselling, as well as those researching or studying related areas. - Presents new best-practice guidelines for using TCR to treat, improve or reverse nutrition-related metabolic conditions and diseases that were previously thought to have a chronic, irreversible progression - Provides an overview of the most recent evidence outlining the biochemistry and physiology pertaining to human nutrition and health - Offers evolutionary and historical context to human nutrition - Contains clinical practice guidelines for the implementation of TCR from medical practitioners who prescribe TCR in their practices, allowing readers to understand real-life concerns in the field - Features case studies that provide practical examples of how to assess, monitor and intervene with patients that practitioners encounter in their practices - Explains the physiology and biochemistry of the normal and pathophysiological state for each condition and links these to the application of TCR

Ischemic Injury
Ischemic Injury

Author: Thakur Gurjeet Singh

Publisher: CRC Press

Published: 2024-11-22

Total Pages: 755

ISBN-13: 100383647X

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The World Stroke Organization reports that “stroke has already reached epidemic proportions. Globally1 in 4 adults over the age of 25 will have a stroke in their lifetime. 12.2 million people worldwide will have their first stroke this year, and 6.5 million will die as a result.” Ischemic strokes are the most common type of stroke, with about 87% of all strokes being ischemic strokes. This new volume addresses this epidemic by presenting detailed studies on ischemic injury, with emphasis on the molecular-level mechanisms and the role of signaling pathways in the body, their structure, and their mechanism of action. The book focuses on molecular pharmacology plans and explains the new areas of research on the discovery of therapeutic molecules that can be used for combating this life-threatening disease. The authors discuss stroke occurrence at different stages of life as well as sex-based differences in its treatment. They cover aspects of the clinical treatment and diagnosis of patients with cardiovascular events, including in-depth information on the prevention, evaluation, therapy selection, result projection, and long-term course of the disease in affected patients. They also detail the involvement of platelets, neurotransmitters, renin-angiotensin-aldosterone system, and vitamin D in ischemic injury.

Treatment of Breast Cancer with Natural Products
Treatment of Breast Cancer with Natural Products

Author: Yachana Mishra

Publisher: Elsevier

Published: 2024-06-07

Total Pages: 266

ISBN-13: 0443299145

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Treatment of Breast Cancer with Natural Based Products is designed to provide a wide spectrum of information and knowledge on phytotherapeutics in breast cancer treatment. With a strong focus on the established research and technology on phytoconstituent-based nanocarriers, the book also covers their rapidly emerging aspects and discusses future research directions in the treatment of breast cancer. Users will find insights into breast cancer symptoms, epidemiology, risk factors, screening, treatment, and drugs delivery systems. Other sections cover Curcumin, Paclitaxel, Quercetin, Resveratrol, Sulforaphane, Epigallocatechin-3-Gallate, Allicin, Berberine, and Vinca Alkaloids in the treatment of breast cancer, along with future perspectives.This book presents a groundbreaking opportunity for both academia and industry to reshape contemporary medical and healthcare approaches. With a specific emphasis on various facets of phytoconstituents within the realm of oncology, this publication serves as a precious asset for researchers, as well as graduate and post-graduate students specializing in oncology, pharmaceutical sciences, biotechnology, and related biomedical fields. - Outlines the anticancer mechanisms shown by phytoconstituents - Provides scholarly insights into recent developments in phytotherapeutics - Assesses the opportunities and challenges of biopolymer-based nanocarriers in cancer research - Focuses on the diverse, cutting-edge techniques for the fabrication of nanocarriers for the drug delivery of anticancer bioactives

Nutraceutical Fruits and Foods for Neurodegenerative Disorders
Nutraceutical Fruits and Foods for Neurodegenerative Disorders

Author: Raj K. Keservani

Publisher: Elsevier

Published: 2023-11-21

Total Pages: 597

ISBN-13: 0443189528

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Nutraceutical Fruits and Foods for Neurodegenerative Disorders presents food-based strategies, specifically related to nutraceuticals, in delaying the onset and slowing down of the propensity of neuronal devastation. In addition to highlighting the positive effects of nutraceutical fruits and foods on brain health, the book also explores the medicinal properties of fruits, vegetables, berries and nutraceuticals, along with their contribution to environmental factors, potential hazards and the need for specific regulatory actions. This book will be a welcomed reference for nutrition researchers, dieticians, nutritionists and academicians studying related fields. - Presents the positive aspects of nutraceutical fruits and food effect on brain health - Highlights the structure activity relationship of constituents present in nutraceuticals in the treatment and cure of neurodegenerative diseases - Explores the nuances of novelty in dosage form design, production, authentication, quality control and market authorization of nutraceuticals