The Minipig in Biomedical Research
The Minipig in Biomedical Research

Author: Peter A. McAnulty

Publisher: CRC Press

Published: 2011-12-19

Total Pages: 713

ISBN-13: 1439811180

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The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.

The Minipig in Biomedical Research
The Minipig in Biomedical Research

Author: Peter A. McAnulty

Publisher: CRC Press

Published: 2011-12-19

Total Pages: 695

ISBN-13: 1439811199

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The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors' global contacts and experience with regulatory authorities and

Advances in Swine in Biomedical Research
Advances in Swine in Biomedical Research

Author: Mike E. Tumbleson

Publisher: Springer Science & Business Media

Published: 1996

Total Pages: 510

ISBN-13: 9780306454967

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Contains papers from the October 1995 symposium, in sections on methods and techniques, and nutrition. Subjects include the Yucatan miniature pig model of ventricular septal defect, the minipig as a model for the study of aging in humans, an external thoracic duct venous shunt to allow for long-term

Swine in the Laboratory
Swine in the Laboratory

Author: M. Michael Swindle

Publisher: CRC Press

Published: 2015-10-28

Total Pages: 843

ISBN-13: 1040057861

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For two decades, Swine in the Laboratory: Surgery, Anesthesia, and Experimental Techniques has been the most respected practical technical guide for medical and veterinary researchers using swine as experimental animals. Extensively updated and expanded since the publication of the second edition in 2007 and now sponsored by the American College of Laboratory Animal Medicine (ACLAM), it continues to be the most authoritative source of scientific and technical information on the use of domestic and miniature swine in research. Additions to the Third Edition Include: New chapters on toxicology, transgenics, cancer models, and necropsy techniques An overview of porcine models that were not included in the previous edition Updates to chapters on the various body systems Contributions from 25 new coauthors, as well as a new coeditor Significant expansions to the accompanying downloadable resources, including new normal data on farm and minipig breeds, videos on training swine and surgical procedures, updated anatomical imaging, and a colored histological atlas Detailed sections on anesthesia, analgesia, and perioperative care present the best current practices for using swine in experimental surgery. Providing a deepened reference of the most current information and best techniques in an increasingly popular field since the publication of the first edition, this book is a vital tool in conducting the best possible research using porcine models.

Recent Advances in Animal Nutrition and Metabolism
Recent Advances in Animal Nutrition and Metabolism

Author: Guoyao Wu

Publisher: Springer Nature

Published: 2021-11-22

Total Pages: 344

ISBN-13: 3030856860

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This book covers hot topics in the nutrition and metabolism of terrestrial and aquatic animals, including the interorgan transport and utilization of water, minerals, amino acids, glucose, and fructose; the development of alternatives to in-feed antibiotics for animals (e.g., swine and poultry); and metabolic disorders (or diseases) resulting from nutrient deficiencies. It enables readers to understand the crucial roles of nutrients in the nutrition, growth, development, and health of animals. Such knowledge has important implications for humans. Readers will also learn from well-written chapters about the use of new genome-editing biotechnologies to generate animals (e.g., cows and swine) as bioreactors that can produce large amounts of pharmaceutical proteins and other molecules to improve the health and well-being of humans and other animals, as well as the growth and productivity of farm animals. Furthermore, the book provides useful information on the use of animals (e.g., cattle, swine, sheep, chickens, and fish) as models in biomedical research to prevent and treat human diseases, develop infant formulas, and improve the cardiovascular and metabolic health of offspring with prenatal growth restriction. Editor of this book is an internationally recognized expert in nutrition and metabolisms. He has about 40 years of experience with research and teaching at world-class universities in the subject matters. He has published more than 660 papers in peer-reviewed journals, 90 chapters in books, and authored two text/reference books, with a very high H-index of 127 and more than 66,000 citations in Google Scholar. This publication is a useful reference for nutrition and biomedical professionals, as well as undergraduate and graduate students in animal science, aquaculture, zoology, wildlife, veterinary medicine, biology, biochemistry, food science, nutrition, pharmacology, physiology, toxicology, and other related disciplines. In addition, all chapters provide general and specific references to nutrition and metabolism for researchers and practitioners in animal agriculture (including aquaculture), dietitians, animal and human medicines, and for government policy makers.

Background Lesions in Laboratory Animals E-Book
Background Lesions in Laboratory Animals E-Book

Author: Elizabeth Fiona McInnes

Publisher: Elsevier Health Sciences

Published: 2011-10-24

Total Pages: 141

ISBN-13: 0702049247

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Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. - over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits - a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals - a chapter on common artifacts that may be observed in histological glass slides - extensive references to each lesion described - aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies

Sourcebook of Models for Biomedical Research
Sourcebook of Models for Biomedical Research

Author: P. Michael Conn

Publisher: Springer Science & Business Media

Published: 2008

Total Pages: 756

ISBN-13: 1588299333

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The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

Oink
Oink

Author: Matt Whyman

Publisher: Simon and Schuster

Published: 2011-09-20

Total Pages: 323

ISBN-13: 1451618301

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In an entertaining cross between Babe and Marley & Me, a family of six (plus a dog, cat, and several chickens) decides to invite two mini-pigs into their chaotic household. Matt Whyman enjoyed a quiet writer’s life in the English countryside . . . until his career wife, Emma, discovered the existence of a pig said to fit inside a handbag. She believes not one but two would be a perfect addition to the already diverse Whyman clan, which includes a dog, a cat, a gaggle of chickens, as well as four children. Nobody could have anticipated the misadventures two little piglets could bring. From stealing his spot on the family sofa to trashing his neighbor’s garden while drunk on fermented apples, Butch and Roxi swiftly establish themselves as “animals of mass distraction.” Funny, touching, and endlessly entertaining, Oink charts the battle of hearts, snouts, and minds between a family man and two mini-pigs.

The Welfare of Pigs
The Welfare of Pigs

Author: Jeremy N. Marchant-Forde

Publisher: Springer Science & Business Media

Published: 2008-11-26

Total Pages: 357

ISBN-13: 1402089090

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The domestic pig is perceived as an animal with intelligence and character and yet, in the industrialized world, the majority of people have had little or no contact with them. Pigs are subject to a wide range of environments from the tropics to the sub-arctic, ranging from small-scale, extensive systems to large-scale intensive systems. They may spend their whole life on one farm or may be subject to long-distance transport multiple times. Not surprisingly, many aspects of their life experiences can impact their welfare. This book brings together a team of leading pig welfare research scientists to review the natural history of the pig, the welfare of pigs at different stages of life and to indicate what the future holds in terms of pig welfare. The text is aimed at researchers and teachers working in veterinary and animal science together with those working in the pig industry and for governmental and non-governmental animal welfare organizations.