Metastasis of Prostate Cancer
Metastasis of Prostate Cancer

Author: Richard J. Ablin

Publisher: Springer Science & Business Media

Published: 2007-09-05

Total Pages: 405

ISBN-13: 1402058470

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This volume brings together the key research issues in clinical and laboratory science relating to metastasis in prostate cancer. Coverage ranges from the most fundamental aspects of the molecular biology of metastasis, to the patient in the clinic. The therapeutic approaches range from conventional drug design to immunogene therapy. Prostate cancer is an area of intense research effort, and this book provides a window on contemporary research in this important area.

Stereotactic Body Radiation Therapy
Stereotactic Body Radiation Therapy

Author: Simon S. Lo

Publisher: Springer Science & Business Media

Published: 2012-08-28

Total Pages: 433

ISBN-13: 364225604X

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Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Prostate Cancer and Bone Metastasis
Prostate Cancer and Bone Metastasis

Author: James P. Karr

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 316

ISBN-13: 1461533988

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The biology of solid tumor metastasis has been the subject of significant scientific and clinical interest for years and while experimental evidence reveals that metastasis is not solely a random event, very little is known about the biology of metastasis originating from prostate cancer. This is in spite of the fact that the majority of prostate cancer patients die with metastatic lesions to the bone. Progress in understanding this most important aspect of prostate cancer has been hampered by the lack of suitable animal models and an inability to accurately quantify bone metastases and their responses to therapy. Over the past decade, scientists in Japan and the United States have steadily advanced our understanding of the cellular, molecular and immunologic biology of primary and disseminated prostate cancer. It is this body of new information, combined with advances in imaging techniques and prostate cancer tumor markers, that prompted the need for an in-depth assessment of bone metastasis of prostate cancer. Accordingly, on December 12, 1990, a group of basic and clinical investigators from Japan and the United States convened in Gotenba, Japan, to hold the first conference devoted solely to the basic biology and clinical aspects of bone metastases originating from prostate cancer. The cross-fertilization of ideas that was fostered through in-depth discussion of technological advances among various basic and clinical disciplines not only further advanced our understanding of prostate metastases to the bone, but suggested approaches for precise quantitative assessment of these lesions and their treatment.

Fast Facts: Metastatic Prostate Cancer
Fast Facts: Metastatic Prostate Cancer

Author: Lance Coetzee

Publisher: Karger Medical and Scientific Publishers

Published: 2017-02-03

Total Pages: 34

ISBN-13: 1910797405

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Information + Taking Control = Best Outcome is the theme running throughout this short, superbly illustrated workbook. Designed to help patients equip themselves with the best information about metastatic prostate cancer, it covers: • how prostate disease spreads and where it can spread to • a summary of diagnostic tests with detailed explanations to aid understanding of PSA levels, staging and Gleason score • all the hormone treatment options and their side effects • what to expect from the disease itself • how to manage key symptoms such as bone pain, urinary problems and fatigue • the treatment options when hormone treatment stops working • useful advice on diet, exercise, and getting the right support • a frank discussion of end of life care • a concise overview of the latest research in this area. With FastTests to test patients' understanding of their condition, handy checklists and plenty of space for patients and their doctors, nurses and family to write notes, this concise, easy-to-read resource will help patients get organized so that they are better equipped to ask the right questions and have more meaningful discussions about their treatment. Ultimately, it will help them make the best decisions about their care. Contents: • Information + Taking Control = Best Outcome • What is metastatic prostate cancer? • What do my test results mean? • Why is my cancer staged? • How will the disease affect me? • How is metastatic prostate cancer treated? • What is available after hormone therapy? • What are the side effects of hormone treatment? • What can I do to help myself? • Monitoring the effects of therapy • Treatment when myeloma returns • End of life care • What is the latest research in this area? • Useful resources

Bone Metastases from Prostate Cancer
Bone Metastases from Prostate Cancer

Author: Francesco Bertoldo

Publisher: Springer

Published: 2016-11-07

Total Pages: 293

ISBN-13: 3319423274

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This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Prostate Cancer
Prostate Cancer

Author: Jack H. Mydlo

Publisher: Elsevier

Published: 2003-07-11

Total Pages: 601

ISBN-13: 0080497896

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An important translational book bridging the gap between science and clinical medicine, Prostate Cancer reviews the biological processes that can be implicated in the disease, reviews current treatments, highlighting the pitfalls where relevant and examines the scientific developments that might result in novel treatments in the future. Key Features * Provides a translational resource for scientists and clinicians working on prostate cancer * Reviews current surgical interventions and highlights their related pitfalls * Presents the latest laparoscopic techniques with figures and illustrations of step-by-step procedures * Offers insight into the potential for novel approaches to treatment in the future * Includes personal perspectives from patients

Managing Metastatic Prostate Cancer In Your Urological Oncology Practice
Managing Metastatic Prostate Cancer In Your Urological Oncology Practice

Author: K.C Balaji

Publisher: Springer

Published: 2016-04-25

Total Pages: 283

ISBN-13: 331931341X

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This text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation strategies, in depth analysis of combination and sequencing strategies, outlines upcoming novel drugs and trends in research, and stresses the role of palliative care in this incurable disease. Managing Metastatic Prostate Cancer in Your Urological Oncology Practice will serve as a very useful resource for physicians and researchers dealing with, and interested in prostate cancer. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and will include the most up to date scientific and clinical information.

Introduction to Cancer Metastasis
Introduction to Cancer Metastasis

Author: Aamir Ahmad

Publisher: Academic Press

Published: 2016-11-14

Total Pages: 418

ISBN-13: 0128040335

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Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe

Mechanisms of Nodal Metastasis in Prostate Cancer
Mechanisms of Nodal Metastasis in Prostate Cancer

Author: James Lee Sung

Publisher:

Published: 2012

Total Pages: 78

ISBN-13:

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Prostate is cancer is the most commonly diagnosed cancer in men worldwide and the second biggest killer among cancer related deaths in men. Due to advances in both detection as well as treatment, the disease can often be caught early when it is still confined within the prostate gland. The prognosis of patients when the disease is still confined within the organ is generally good. However, the prognosis in patients when the disease has spread to regional lymph nodes is very poor. Metastatic prostate cancer accounts for nearly all the mortality associated with prostate cancer. Numerous clinical studies have documented the importance of lymph node involvement in predicting patient survival. These data suggest that not only is lymph node involvement an important indicator of systemic metastases, they may be an active participant in the process. In the present report, we provide insight into mechanisms that are involved in prostate cancer metastasis to lymph nodes. First, we examine the relationship between the lymphangiogenic mechanisms and prostate dissemination to lymph nodes. Second we, offer insight into lymph node specific homing mechanisms used by prostate cancer cells. Finally, we describe a strategy to interrogate the significance of lymph nodes as a reservoir of malignant cells that can fuel future metastatic dissemination. A better understanding of the mechanisms involved in lymph node metastasis will allow us to better treat the metastatic disease.